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• Clinical Article •
Value of 3D ASL in evaluation cerebral hemodynamics before and after thrombolytic therapy in acute cerebral infarction
LIU Na  LI Dao-wei  MA Qiang  HE Dan 

DOI:10.12015/issn.1674-8034.2017.11.002.


[Abstract] Objective: To evaluate the value of 3D whole-brain pseudo-continuous arterial spin labeling imaging (3D ASL) in evaluationg the thrombolytic therapy in patients with acute cerebral infarction.Materials and Methods: Conventional plain MRI, diffusion weighted imaging (DWI) and 3D ASL were performed on 20 patients with acute cerebral infarction within 10 hours after onset of symptom. All patients were reexamined cerebral plain MRI, DWI and 3D ASL after thrombolysis between 1—7 day. Cerebral blood flow (CBF) of infarction area and normal control area was carried out on 3D ASL images before and after thrombolytic therapy.Results: All 20 cases showed early infaction signs on DWI with ADC decreased and hypoperfusion on 3D ASL with CBF decreased corresponding to clinical symptoms. The abnormal area was larger on 3D ASL than DWI. Follow-up 3D ASL showed that after thrombolysis 18 cases with samller hypoperfusion, 2 cases with larger hypoperfusion and 10 cases with hyperferfusion. There was statisticaly significant difference between the CBF on ischemic region before and after thrombolysis (P<0.05).Conclusions: As a new noninvasive perfusion imaging technique, 3D ASL can depict detailed hemodynamic information before and afer thrombolysis, and provide important basis for evaluating the effect of thrombolytic therapy in patients with acute cerebral infarction.
[Keywords] Magnetic resonance imaging；Acute cerebral infarction；Thrombolysis；Perfusion imaging

LIU Na Department of Radioloy, the People's Hospital of Liaoning Province, Shenyang 110016, China

LI Dao-wei Department of Radioloy, the People's Hospital of Liaoning Province, Shenyang 110016, China

MA Qiang* Department of Radioloy, the People's Hospital of Liaoning Province, Shenyang 110016, China

HE Dan Department of Radioloy, the People's Hospital of Liaoning Province, Shenyang 110016, China

*Correspondence to: Ma Q, E-mail: maqiang834@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Natural Science Foundation of Liaoning Province No. 201602427
Received  2016-06-21
Accepted  2016-11-08
DOI: 10.12015/issn.1674-8034.2017.11.002
DOI:10.12015/issn.1674-8034.2017.11.002.

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