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• Clinical Article •
Diagnostic value of DWI on brain anaplastic ependymoma with glioblastoma multiforme
ZHANG Guo-Jin  MA Li  WANG Dan  ZHANG Wen-Juan  ZHOU Jun-Lin 

DOI:10.12015/issn.1674-8034.2017.11.003.


[Abstract] Objective: To compare imaging features of the brain anaplastic ependymoma and glioblastoma multiforme (GBM), exploring the value of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) value in differential diagnosis of them.Materials and Methods: Collect the essence of 18 cases with brain surgery and pathology room brain anaplastic ependymoma and 25 cases of GBM patients with preoperative MR scan, enhanced scan and DWI imaging examination data, analyzed the MRI images, and measure the two groups of tumor of the average ADC value for Mann-Whitney U rank test, using receiver operating characteristic (ROC) curve to evaluate the differential diagnostic value of ADC value.Results: Twenty-five cases of GBM DWI in 19 cases showed high or slightly high signal, 6 cases showed low signal, the mean value of ADC was (0.83±0.06)×10-3 mm2/s. Eighteen cases of brain anaplastic ependymomain 14 cases of DWI showed high or slightly high signal, 4 cases showed low signal, the average ADC (1.15±0.12)×10-3 mm2/s. The difference was statistically significant higher than that of GBM (t=9.43, P<0.001). With the ADC value of 0.96×10-3 mm2/s as the diagnostic threshold, the area under the ROC curve is equal to 0.92±0.04, the 95% confidence interval is 0.84 to 1, sensitivity is 90%, specificity is 95%, accuracy is 90%.Conclusions: There are some differences between the MRI signs of brain anaplastic ependymoma and GBM, ADC value has important reference value in the differential diagnosis, can improve the diagnostic accuracy.
[Keywords] Glioblastoma；Ependymoma；Diffusion magnetic resonance imaging；Diagnosis, differential

ZHANG Guo-Jin Department of Radiology, Second Hospital Affiliated to Lanzhou University, Lanzhou, 730030, China

MA Li Department of Radiology, Second Hospital Affiliated to Lanzhou University, Lanzhou, 730030, China

WANG Dan Department of Radiology, Second Hospital Affiliated to Lanzhou University, Lanzhou, 730030, China

ZHANG Wen-Juan Department of Radiology, Second Hospital Affiliated to Lanzhou University, Lanzhou, 730030, China

ZHOU Jun-Lin* Department of Radiology, Second Hospital Affiliated to Lanzhou University, Lanzhou, 730030, China

*Correspondence to: Zhou JL, E-mail: zjl601@163.com

Conflicts of interest   None.

Received  2017-04-06
Accepted  2017-10-09
DOI: 10.12015/issn.1674-8034.2017.11.003
DOI:10.12015/issn.1674-8034.2017.11.003.

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