• Clinical Article •
The clinical study on the Gd-EOB-DTPA-enhanced MR imaging for analysis of liver function and comparison with serologic results
DOI:10.12015/issn.1674-8034.2017.11.007.
| [Abstract] Objective: To investigate the clinical significance of Gd-EOB-DTPA to predict and evaluate the liver function.Materials and Methods: Gd-EOB-DTPA-enhanced MR images of 98 patients were conducted on a 3.0 Tesla MRI. The values of relative enhancement ratio (rER) and Child-Pugh scores were calculated. Serologic testing was obtained within 7 days before and after MRI. The comparison between different Child-Pugh groups was accomplished by One-Way ANOVA. Spearman rank correlation was applied to analyze the relationship between the rER values and serologic results.Results: The results showed statistical differences among rER values of different Child-Pugh groups and normal group (P<0.05). The mean values are respectively 2.281±0.275, 2.092±0.474, 1.824±0.246, 1.711±0.433. Comparative analysis between every two groups was applied and the results showed that normal and Child-Pugh B, normal and Child-Pugh C, Child-Pugh A and Child-Pugh B indicated statistical significance. The linear regression analysis showed that P value between rERs and values of TBIL, ALT, AST, PT, PTA, PA, ChE were less than 0.05, which was significant statistically.Conclusions: The rER values of EOB-MRI could be used to evaluate liver function and to identify mild, moderate liver damage significantly. It got the most intimate relation with prothrombin activity and prealbumin. |
| [Keywords] Contrast media；Liver function；Serology；Magnetic resonance imaging |
ZHU Wang-shu Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
SHI Si-ya Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
YANG Qi-hua Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
SONG Chao Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
LI Yong* Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
*Correspondence to: Li yong, E-mail: aliyong@126.com
Conflicts of interest None.
| ACKNOWLEDGMENTS Supported by the Natural Science Foundation of Guangdong Province, China No. S2013010016131 |
| Received 2017-07-03 |
| Accepted 2017-10-09 |
| DOI: 10.12015/issn.1674-8034.2017.11.007 |
| DOI:10.12015/issn.1674-8034.2017.11.007. |
[1]
Manizate F, Hiotis SP, Labow D, et al. Liver functional reserve estimation: state of the art and relevance to local treatments. Oncology, 2010, 78(Suppl 1): 131-134.
[2]
Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg, 1973, 60(8):646-649.
[3]
中华医学会放射学分会腹部学组.肝胆特异性MRI对比剂钆塞酸二钠临床应用专家共识.中华放射学杂志, 2016, 50(9):641-646.
[4]
Lau H, Man K, Fan ST, et al. Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy. Br J Surg, 1997, 84(9): 1255-1259.
[5]
Imura S, Shimada M, Utsunomiya T. Recent advances in estimating hepatic functional reserve in patients with chronic liver damage. Hepatol Res, 2015, 45(1): 10-19.
[6]
Jaw TS, Chen SH, Wang YM, et al. Comparison of Gd-BZ-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models. Kaohsiung J Med Sci, 2012, 28(3): 130-137.
[7]
刘珏，Gurung M，朱望舒,等.肝特异性对比剂对肝功能解剖分布的初步探讨.岭南现代临床外科, 2015, 15(5): 546-549.
[8]
Motosugi U, Ichikawa T, Sou H, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced mr imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging, 2009, 30(5): 1042-1046.
[9]
涂蓉，罗建光，郑进光,等. CT测量保留肝容积率对肝癌切除术前肝储备功能的评估价值.中华放射学杂志, 2005, 39(7): 710-713.
[10]
Shimizu J, Dono K, Gotoh M, et al. Evaluation of regional liver function by Gadolinium-EOB-DTPA-enhanced MR imaging. Dig Dis Sci, 1999, 44(7): 1330-1337.
[11]
Verloh N, Haimerl M, Rennert J, et al. Impact of liver cirrhosis on liver enhancement at Gd-EOB-DTPA enhanced MRI at 3 tesla. Eur Radiol, 2013, 82(10): 1710-1715.
[12]
Utsunomiya T, Shimada M, Hanaoka J, et al. Possible utility of mri using Gd-EOB-DTPA for estimating liver functional reserve. J Gastroenterol, 2012, 47(4): 470-476.
[13]
韩丹，张洁，靳二虎,等.钆塞酸二钠增强MRI评价原发性胆汁性胆管炎患者肝功能的可行性研究.磁共振成像, 2017, 8(5):337-342.
[14]
Matsushima S, Sato Y, Yamaura H, et al. Visualization of liver uptake function using the uptake contrast-enhanced ratio in hepatobiliary phase imaging. Magn Reson Imaging, 2014, 32(6): 654-659.
[15]
Kim HY, Choi JY, Park CH, et al. Clinical factors predictive of insufficient liver enhancement on the hepatocyte-phase of Gd-EOB-DTPA-enhanced magnetic resonance imaging in patients with liver cirrhosis. J Gastrolenterol, 2013, 48(10): 1180-1187.
[16]
Geier A, Kim SK, Gerloff T, et al. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. J Hepatol, 2002, 37(2): 198-205.
