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• Clinical Article •
The clinical study on the Gd-EOB-DTPA-enhanced MR imaging for analysis of liver function and comparison with serologic results
ZHU Wang-shu  SHI Si-ya  YANG Qi-hua  SONG Chao  LI Yong 

DOI:10.12015/issn.1674-8034.2017.11.007.


[Abstract] Objective: To investigate the clinical significance of Gd-EOB-DTPA to predict and evaluate the liver function.Materials and Methods: Gd-EOB-DTPA-enhanced MR images of 98 patients were conducted on a 3.0 Tesla MRI. The values of relative enhancement ratio (rER) and Child-Pugh scores were calculated. Serologic testing was obtained within 7 days before and after MRI. The comparison between different Child-Pugh groups was accomplished by One-Way ANOVA. Spearman rank correlation was applied to analyze the relationship between the rER values and serologic results.Results: The results showed statistical differences among rER values of different Child-Pugh groups and normal group (P<0.05). The mean values are respectively 2.281±0.275, 2.092±0.474, 1.824±0.246, 1.711±0.433. Comparative analysis between every two groups was applied and the results showed that normal and Child-Pugh B, normal and Child-Pugh C, Child-Pugh A and Child-Pugh B indicated statistical significance. The linear regression analysis showed that P value between rERs and values of TBIL, ALT, AST, PT, PTA, PA, ChE were less than 0.05, which was significant statistically.Conclusions: The rER values of EOB-MRI could be used to evaluate liver function and to identify mild, moderate liver damage significantly. It got the most intimate relation with prothrombin activity and prealbumin.
[Keywords] Contrast media；Liver function；Serology；Magnetic resonance imaging

ZHU Wang-shu Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China

SHI Si-ya Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China

YANG Qi-hua Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China

SONG Chao Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China

LI Yong* Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China

*Correspondence to: Li yong, E-mail: aliyong@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by the Natural Science Foundation of Guangdong Province, China No. S2013010016131
Received  2017-07-03
Accepted  2017-10-09
DOI: 10.12015/issn.1674-8034.2017.11.007
DOI:10.12015/issn.1674-8034.2017.11.007.

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