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Brain structure and resting-state functional MRI study of obstructive sleep apnea-hypopnea syndrome
QIN Zong-yuan  BAO Hai-hua  WU You-sen  ZHANG Hong-qian 

DOI:10.12015/issn.1674-8034.2017.11.011.


[Abstract] Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a sleep respiratory disease induced by a variety of factors. The chronic hypoxia can lead to a decrease in executive function, memory, motor coordination, attention, and cognition. In recent years, some scholars have studied the brain structure and resting state brain function in patients with OSAHS. They found that the brain structure and function in patients with OSAHS have a certain change and these changes in the brain are associated with some cognitive and behavioral decline in the patient. This article will review the changes in brain structure and brain function of OSAHS, and hope to have some assistance in the neuroimaging and clinical diagnosis and treatment of OSAHS.
[Keywords] Sleep apnea, obstructive；Magnetic resonance imaging；Organ size

QIN Zong-yuan The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xi’ning 810001, China

BAO Hai-hua* The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xi’ning 810001, China

WU You-sen The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xi’ning 810001, China

ZHANG Hong-qian The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xi’ning 810001, China

*Correspondence to: Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  The project is supported by the National Natural Science Foundation of China No. 81060117 the Qinghai Science and Technology Project of China No. 2012-H-807
Received  2017-06-13
Accepted  2017-08-10
DOI: 10.12015/issn.1674-8034.2017.11.011
DOI:10.12015/issn.1674-8034.2017.11.011.

[1]
Stradling JR, Davies RJ. Sleep.1: Obstructive sleep apnoea/hypopnoea syndrome: definitions, epidemiology, and natural history. Thorax, 2004, 59(1): 73-78.
[2]
Alper K, Elif YO, Tuncay H, et al. Early myocardial functional alterations in patients with obstructive sleep apnea syndrome. Echocardiography, 2009, 26(4): 388-396.
[3]
Aslan K, Deniz A, Cayli M, et al. Early left ventricular functional alterations in patients with obstructive sleep apnea syndrome. Cardiol J, 2013, 20(5): 519-525.
[4]
Verstraeten E. Neurocognitive effects of obstructive sleep apnea syndrome. Current Neurol Neuroscien Reports, 2007, 7(2): 161-166.
[5]
Bennett LS, Barbour C, Langford B, et al. Health status in obstructive sleep apnea relationship with sleep fragmentation and daytine sleepiness, and effects of continuous positive airway pressure treatment. Am J Respir Crit Care Med, 1999, 159(6): 1884-1890.
[6]
Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc, 2008, 5(2): 136-143.
[7]
Aloia MS, Arnedt JT, Davis JD, et al. Europsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review. J Int Neuropsychological Society, 2004, 10(5): 772-785.
[8]
Melhem ER, Mori S, Mukundan G, et al. Diffusion tensor MR imaging of the brian and white matter tractography. AJR Am J Roentgenol, 2002, 178(1): 3-16.
[9]
Song XW, Dong ZY, Long XY, et al. REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One, 2011, 6(9): 1-12.
[10]
Adachi S, Lowe AA, Tsuchiya M, et al. Genioglossus muscle activity and inspiratory timing in obstructive sleep apnea. Am J Orthod Dentofacial Orthop, 1993, 104(2): 138-145.
[11]
Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet, 2014, 383(9918): 736-747.
[12]
Madani M. Snoring and sleep apnea. Arch Iranian Med, 2007, 10(2):215-226.
[13]
中华医学会呼吸病学分会睡眠呼吸障碍学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(2011年修订版).柳州医学, 2012,35(3): 162-165.
[14]
Ashburner J, Friston KJ. Voxel-based morphometry: the methods. Neuroimage, 2000, 11(6): 805-821.
[15]
张敬，张成周，张云亭.基于体素的形态学测量技术临床应用进展.国际医学放射学杂志, 2010, 33(4): 314-317.
[16]
Yaouhi K, Bertran F, Clochon P, et al. A combined neuropsychological and brain imaging study of obstructive sleep apnea. J. Sleep Res, 2009, 18(1): 36-48.
[17]
Macey PM, Henderson LA, Macey KE, et al. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med Vol, 2002, 166(10): 1382-1387.
[18]
Torelli F, Moscufo N, Garreffa G, et al. Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage, 2011, 54(2): 787-793.
[19]
Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res, 2002, 11(1): 1-16.
[20]
Aloia MS, Arnedt JT, Davis JD, et al. Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review. J Int Neuropsychol Soc, 2004, 10(5): 772-785.
[21]
Saunamaki T, Jehkonen M. A review of executive functions in obstructive sleep apnea syndrome. Acta Neurol. Scand, 2007, 115(1): 1-11.
[22]
Canessa N, Castronovo V, Cappa SF, et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med, 2011, 183(10): 1419-1426.
[23]
O'Donoghue FJ, Briellmann RS, Rochford PD, et al. Cerebral structural changes in severe obstructive sleep apnea. Am J Respir Crit Care Med Vol, 2005, 171(10): 1185-1190.
[24]
Joo EY, Tae WS, Lee MJ, et al. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome. Sleep, 2010, 33(2): 235-241.
[25]
Macey PM, Kumar R, Woo MA, et al. Brain structural changes in obstructive sleep apnea. Sleep, 2008, 31(7): 967-977.
[26]
Macey PM, Kumar R, Yan-Go FL, et al. Sex differences in white matter alterations accompanying obstructive sleep apnea. Sleep, 2012, 35(12):1603-1613.
[27]
曹岂溱.磁共振扩散张量成像对阻塞性睡眠呼吸暂停低通气综合征患者脑白质损害的评价.河北:河北医科大学, 2015: 246-250.
[28]
Chen HL, Lu CH, Lin HC, et al. White matter damage and systemic inflammation in obstructive sleep apnea. Sleep, 2015, 38(3): 361.
[29]
Castronovo V, Scifo P, Castellano A, et al. White matter integrity in obstructive sleep apnea before and after treatment. Sleep, 2014, 37(9): 1465-1475.
[30]
张向前，陆兵勋，李涛平.阻塞性睡眠呼吸暂停综合征白质损害特点与记忆功能的关系.南方医科大学学报, 2009, 29(4): 825-829.
[31]
Xiong Y, Zhou XJ, Karaman MM, et al. Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness. J Magn Reson Imaging, 2017, 45(5): 1371-1378.
[32]
Joo EY, Jeon S, Kim ST, et al. Localized cortical thinning in patients with obstructive sleep apnea syndrome. Sleep, 2013, 36(8):1153-1162.
[33]
Baril AA, Gagnon K, Brayet P. Gray matter hypertrophy and thickening with obstructive sleep apnea in middle-aged and older adults. Am J Respir Crit Care Med. 2017, 195(11): 1509-1518.
[34]
Algin O, Akin B, Ocakoglu G. Fully automated morphological analysis of patients with obstructive sleep apnea. Turk J Med Sci, 2016, 46(2): 343-348.
[35]
Dalmases M, Solé-Padullés C, Torres M. Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA: a randomized pilot study. Chest, 2015, 148(5): 1214-1223.
[36]
Tian L, Ren J, Zang Y. Regional homogeneity of resting state fMRI signals predicts Stop signal task performance. Neuroimage, 2012,60(1): 539-544.
[37]
Ogawa S, Lee TM, Kay AR, et al. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc NatI Acad Sci U S A, 1990, 87(24): 9868-9872.
[38]
陈婷，杨明，刘斌,等.阻塞性睡眠呼吸暂停低通气综合征患者脑功能局部一致性磁共振观察.中华医学杂志, 2016, 96(11): 868-873.
[39]
张泉.阻塞性睡眠呼吸暂停低通气综合征的静息态脑功能磁共振成像研究.天津:天津医科大学, 2012: 4-6.
[40]
穆新暖，王滨，王晓芝,等.呼吸睡眠暂停低通气患者脑功能的功能性MRI诊断.放射学实践, 2017, 32(1): 16-20.
[41]
Santarnecchi E, Sicilia I, Richiardi J, et al. Altered cortical and subcortical local coherence in obstructive sleep apnea: a functional magnetic resonance imaging study. J Sleep Res, 2013, 22(3): 337-347.
[42]
Peng DC, Dai XJ, Gong HH, et al. Altered intrinsic regional brain activity in male patients with severe obstructive sleep apnea: a resting-state functional magnetic resonance imaging study. Neuropsychiatr Dis Treat, 2014, 10: 1819-1826.
[43]
Zhang Q, Wang DW, Qin W, et al. Altered resting-state brain activity in obstructive sleep apnea. Sleep, 2013, 36(5): 651-659.
[44]
Li HJ, Nie X, Gong HH, et al. Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea. Neuropsychiatr Dis Treat, 2016, 12: 203-212.
[45]
Li C, Ma X, Dong M, et al. Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study. Neuropsychiatr Dis Treat, 2016, 12: 1371-1378.
[46]
Zhang Q, Qin W, He X, et al. Functional disconnection of the right anterior insula in obstructive sleep apnea. Sleep Med, 2015, 16(9):1062-1070.
[47]
Park B, Palomares JA, Woo MA, et al. Aberrant insular functional network integrity in patients with obstructive sleep apnea. Sleep,2016, 39(5): 989-1000.
[48]
Park B, Palomares JA, Woo MA, et al. Disrupted functional brain network organization in patients with obstructive sleep apnea. Brain Behav, 2016, 6(3): 1-17.
[49]
Tahmasian M, Rosenzweig I, Eickhoff SB, et al. Structural and functional neural adaptations in obstructive sleep apnea: an activation likelihood estimation meta-analysis. Neurosci Biobehav Rev, 2016,65: 142-156.
[50]
Uddin LQ. Salience processing and insular cortical function and dysfunction. Nat Rev Neurosci, 2015, 16(1): 55-61.
[51]
Taylor KS, Kucyi A, Millar PJ, et al. Association between resting-state brain functional connectivity and muscle sympathetic burst incidence. J Neurophysiol, 2016, 115(2): 662-673.
[52]
Gusnard DA, Akbudak E, Shulman GL, et al. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A, 2001, 98(7): 4259-4264.
[53]
Spreng RN, Stevens WD, Chamberlain JP, et al. Chamberlain. Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition. Neuroimage, 2010, 53(1):303-317.
[54]
Li H, Li L, Shao Y. Abnormal intrinsic functional hubs in severe male obstructive sleep apnea: evidence from a voxel-wise degree centrality analysis. PloS One, 2016, 11(10): 1-18.
[55]
Chen LT, Fan XL, Li HJ. Disrupted small-world brain functional network topology in male patients with severeobstructive sleep apnea revealed by resting-state fMRI. Neuropsychiatr Dis Treat, 2017, 13:1471-1482.
[56]
Luo YG, Wang D, Liu K, et al. Brain structure network analysis in patients with obstructive sleep apnea. PloS One, 2015, 10(9): 1-13.

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