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• Clinical Article •
SWI and DKI study of brain iron deposition and microstructure change in gray matter nucleus in Parkinson's disease
GAO Bing-bing  MIAO Yan-wei  TIAN Shi-yun  SHANG Jin  LIUYANG Ying-qiu  HAN Liang 

DOI:10.12015/issn.1674-8034.2017.12.001.


[Abstract] Objective: To explore the relationship between iron overload and microstructure change in the latter two levels, and further to compare and correlate the parameters from DKI and SWI in extrapyramidal systemic nuclei of Parkinson's disease (PD) patients and healthy controls.Materials and methods: This study was prospective and was approved by the hospital ethics committee. Thirty-five clinically confirmed PD patients and twenty-three healthy volunteers were enrolled in this study. PD group including 18 males and 17 females (mean age 67.00±8.76 years). Healthy control group (HC group) including 12 males and 11 females (mean age 66.48±5.2 years). All patients performed conventional MRI sequence, SWI sequence and DKI sequence scan. Bilateral Phase value, MD value, Da value, Dr value, MK value, Ka value, Kr value and FA value of the head of caudate nuclei, putamen, globus pallidus, thalamus, red nucleus, substantia nigra were measured. Two independent samples t-test was used to compare the phase value in all brain regions between the PD and HC groups. The correlations between SWI and DKI parameters of each nuclei of PD group were analyzed using Spearman correlation. All measurement data were shown as mean value and standard deviation. For all statistical analyses, a level of significance of P<0.05.Results: The phase value decreased in substantia nigra, red nucleus, globus pallidus and the head of caudate nuclei while increased in putamen of patients with PD compared to the HC group (all P<0.05). It showed positive correlation between the Phase value and Kr value in substantia nigra (r=0.349, P=0.030) and the Phase value and Da value in red nucleus (r=0.414, P=0.009); meanwhile, negative correlation between the Phase value and FA value in left putamen was found.Conclusions: The iron overload exists in every gray matter nucleus of the extrapyramidal system in PD patients. There are some relation between the iron overload and the change of microstructure in substantia nigra, red nucleus and putamen of patients with PD.
[Keywords] Parkinson's disease；Magnetic resonance imaging；Diffusion kurtosis imaging；Susceptibility weighted imaging；Gray matter nucleus

GAO Bing-bing Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

MIAO Yan-wei* Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

TIAN Shi-yun Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

SHANG Jin Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LIUYANG Ying-qiu Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

HAN Liang Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

*Corresponding to: Miao YW, E-mail: ywmiao716@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671646
Received  2017-05-28
Accepted  2017-10-19
DOI: 10.12015/issn.1674-8034.2017.12.001
DOI:10.12015/issn.1674-8034.2017.12.001.

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