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• Clinical Article •
Analysis of metabolite levels in brain of preterm neonates by using multi-voxel magnetic resonance spectroscopy
WANG Hong  QIN Ming-ming  TANG Wen-lin  QIAN Wei-liang  YANG Zu-ming  YAN Bo-qiu  XU Jian-ming 

DOI:10.12015/issn.1674-8034.2017.12.003.


[Abstract] Objective: To investigate the influence for metabolite levels in brain of preterm neonates who suffered perinatal asphyxia or perinatal infection by using multi-voxel magnetic resonance spectroscopy.Materials and methods: A total of 60 preterm neonates at term-equivalent age underwent MRI examination. The MRI examinations including multi-voxel 1H-MRS and other conventional plain sequences were performed using MAGNETOM Skyra (Siemens Healthcare, Erlangen, Germany), and 48 preterm infants were finally enrolled in this study and were divided into four groups: Group 1 (n=13, perinatal normal), Group 2 (n=10, perinatal asphyxia), Group 3 (n=12, perinatal infection) and Group 4 (n=13, perinatal asphyxia and infection). NAA/Cr, Cho/Cr, Lac/Cr ratios were collected from voxels located the basal ganglia and thalami (BGT) and periventricular white matter (WM), and all metabolic data were analyzed by SPSS 21.0 statistical software. Metabolic values were analyzed by t test in Group 1 and were analyzed by one-way ANOVA across 4 groups, if P<0.05, q test for multiple comparisons were analyzed by SNK method.Results: ① The differences of both NAA/Cr and Cho/Cr between anterior periventricular white matter and posterior periventricular white matter were statistically significant in Group 1 (P<0.001). ② In BGT region, the differences of all metabolic values including NAA/Cr, Cho/Cr and Lac/Cr were statistically significant between Group 1 and Group 2, between Group 1 and Group 4, between Group 2 and Group 3, between Group 3 and Group 4. ③ In region of WM, the differences of all metabolic values including NAA/Cr, Cho/Cr, Lac/Cr were statistically significant between Group 1 and Group 2, between Group 1 and Group 4, between Group 3 and Group 4; The difference of Cho/Cr was statistically significant between Group 1 and Group 3, between Group 2 and Group 4; The differences of both NAA/Cr and Lac/Cr were statistically significant between Group 2 and Group 3.Conclusions: ① The antero-posterior gradient of myelinization in periventricular white matter exist in preterm neonates, the development of myelinization is more maturer in posterior periventricular white matter. ② Perinatal asphyxia affects directly the process of myelination and disrupts neuronal and axonal integrity. ③ Perinatal infection only affects the process of myelination in periventricular white matter.
[Keywords] Magnetic resonance spectroscopy；Preterm neonate；Perinatal asphyxia；Peripartum period；Magnetic resonance imaging；White matter

WANG Hong Department of Radiology, Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China

QIN Ming-ming Department of Radiology, Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China

TANG Wen-lin SIEMENS Medical Systems Ltd, Shanghai 201318, China

QIAN Wei-liang Department of Radiology, Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China

YANG Zu-ming Department of Neonatology, Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China

YAN Bo-qiu Department of Children Healthcare, Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China

XU Jian-ming* Department of Radiology, Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China

*Corresponding to: Xu JM, E-mail: jmxu86@163.com

Conflicts of interest   None.

Received  2017-08-25
Accepted  2017-10-23
DOI: 10.12015/issn.1674-8034.2017.12.003
DOI:10.12015/issn.1674-8034.2017.12.003.

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