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• Original Article •
Liver ESWAN and serum ferritin for quantitative evaluation of liver fibrosis: An experimental study
WANG Dan  CHEN Tian-wu  LIU Qi-yu  ZHANG Xiao-ming  YI Guang-ming 

DOI:10.12015/issn.1674-8034.2017.12.008.


[Abstract] Objective: To investigate whether the value of T2* and magnitude images of ESWAN (enhanced T2* weight angiography) and the serum ferritin could determine liver fibrosis and evaluate the liver fibrosis stage.Materials and Methods: Sixty four new zealand white rabbits in this study, eight rabbits were as normal control group and fifty six rabbits were used to model liver fibrosis with CCL4 by intraperitoneal injection. The rabbits underwent MRI scan on 6th, 8th, 10th and 12th week after beginning of modeling the liver fibrosis. The values of T2* and magnitude images were obtained and got the liver METAVIR stage, and acquired the value of serum ferritin by ELISA.Results: The values of T2* and magnitude were decreased with increasing stage of fibrosis (r=-0.588, -0.388 respectively; all P<0.05) while the value of serum ferritin was increased (r=0.409, P<0.05). The value of T2* could distinguish normal group from F2, F3 and F4 respectively, F1 from F4, F1 from F2-4 (all P<0.05), and the AUC≥0.74. The value of magnitude imagine could distinguish the normal group from F4, F1 from F4 and F1-3 from F4 (all P<0.05), and the AUC≥0.822. The value of serum ferritin could differentiate normal group from F3, F4 respectively (all P<0.05), and the AUC≥0.873.Conclusions: The value of T2* and magnitude and serum ferritin could quantificationally determine the presence and the severity of fibrosis.
[Keywords] Magnetic resonance imaging；Liver fibrosis；Serum ferritin；METAVIR stage；Animal experimentation

WANG Dan Department of Radiology, Mianyang Central Hospital, Mianyang 621000, China; Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

CHEN Tian-wu* Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

LIU Qi-yu Department of Radiology, Mianyang Central Hospital, Mianyang 621000, China

ZHANG Xiao-ming Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

YI Guang-ming Department of Oncology, the Third Hospital of Mianyang, Mianyang 621000, China

*Correspondence to: Chen TW, E-mail: chentw@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81050033
Received  2017-07-14
Accepted  2017-09-06
DOI: 10.12015/issn.1674-8034.2017.12.008
DOI:10.12015/issn.1674-8034.2017.12.008.

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