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• Technical Article •
The application of different NEX amide proton transfer imaging in brain tumors on 1.5 T MRI scanner
YANG Yong-gui  GUO Gang 

DOI:10.12015/issn.1674-8034.2017.12.009.


[Abstract] Objective: To analyze the effects of different number of excitation (NEX) amide proton transfer imaging in brain tumors on 1.5 T MRI scanner.Materials and Methods: The data acquisitions were carried out in clinical cases using GE Signa HDe 1.5 T MRI. The data were collected and analyzed on the analysis of the different NEX, such as the original signal, APT signal.Results: In the comparative analysis group, NEX=2 and 8, the original image quality scores were 4.55±0.83, 4.60±0.68, respectively, and there was no statistical difference; The image quality scores of the APT image were 2.7±1.03, 3.35±0.81 respectively, a statistically significant difference. The sensitivity of original image is 100%, and the sensitivity of APT image is 70% and 90%, respectively. In the random packet analysis group, NEX=2 and 8, the original image quality scores were 4.54±0.78, 4.69±0.63, respectively, and there was no statistical difference; The image quality score APT image were 2.89±0.96, 3.60±0.69, a statistically significant difference. The sensitivity of original image is 100%, and the sensitivity of APT image is 77.1% and 94.3%, respectively. No matter what a group of results, all APT images are down a file than the original images. The APT images signal to noise ratio (SNR) is relatively low, but can display and distinguish lesions.Conclusions: APT imaging after optimizing parameters, the distribution of lesions can clearly distinguish brain tumors, brain tumors and other biological metabolites presenting information from the level of molecular imaging studies, the scope of early diagnosis and evaluation of tumor and its relationship with the surrounding anatomical structure, has important significance to tumor prognosis and treatment. If the subject is unable to tolerate, the APT image of NEX=2 can also provide relatively satisfactory APT imaging results.
[Keywords] Magnetic resonance imaging；Chemical exchange saturation transfer；Amide proton transfer；Brain neoplasms

YANG Yong-gui Department of medical imaging, the Second Affiliated Hospital of Xiamen Medical College, Xiamen 361021, China

GUO Gang* Department of medical imaging, the Second Affiliated Hospital of Xiamen Medical College, Xiamen 361021, China

*Correspondence to: Guo G, E-mail: guogangxm@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Xiamen Science and Technology Bureau Huimin Project No. 3502Z20144052
Received  2017-08-05
Accepted  2017-09-06
DOI: 10.12015/issn.1674-8034.2017.12.009
DOI:10.12015/issn.1674-8034.2017.12.009.

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