Share：
Share this content in WeChat
X
[Chinese][PDF]77798
• Review •
Research progress of functional MRI in irritable bowel syndrome
LI Jie  DING Jian-ping 

DOI:10.12015/issn.1674-8034.2017.12.013.


[Abstract] The mechanism of irritable bowel syndrome (IBS) may be related to such factors as visceral hypersensitivity, abnormal intestinal motility, inflammation, psychological factors and so on. However, the symptoms of the disease could explain the lack of morphological changes and biochemical abnormalities. The etiology and pathogenesis of the disease are still unclear. The role of the "brain gut axis" in the pathogenesis of IBS has attracted wide attention and has become a breakthrough point in the study of IBS pathogenesis. Functional magnetic resonance imaging (fMRI) is a noninvasive method detecting neural activity, and has the ability to observe the brain tissue microstructure and functional changes in vivo. FMRI provides a new angle of view for evaluating the central mechanism of "brain gut axis", and also can display the activity of brain and changes in the nerve pathways in IBS patients. In addition, it also has important significance to evaluate the therapeutic effect. This article reviews the present research situation and progress of fMRI in IBS diagnosis and its therapeutic efficacy.
[Keywords] Irritable bowel syndrome；Magnetic resonance imaging；Brain structures；Brain function

LI Jie Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China

DING Jian-ping* Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China

*Corresponding to: Ding JP, E-mail: jpding@vip.sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Public Technology Research and Social Development Projects of Zhejiang province No. 2015C33292
Received  2017-09-20
Accepted  2017-11-13
DOI: 10.12015/issn.1674-8034.2017.12.013
DOI:10.12015/issn.1674-8034.2017.12.013.

[1]
Basilisco G. Pathogenes is of irritable bowel syndrome: current understanding. Recenti Prog Med, 2007, 98(11): 543-547.
[2]
Seminowicz DA, Labus JS, Bueller JA, et al. Regional gray matter density changes in brains of patients with irritable bowel syndrome. Gastroenterology, 2010, 139(1): 48-57.
[3]
Blankstein U, Chen J, Diamant NE, et al. Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors. Gastroenterology, 2010, 139(5): 1783-1789.
[4]
方金，江桂华，许鸣,等.肠易激综合征患者的灰质体积改变: VBM方法研究.临床放射学杂志, 2013, 32(12): 1702-1705.
[5]
Hong JY, Labus JS, Jiang Z, et al. Regional neuroplastic brain changes in patients with chronic inflammatory and non-inflammatory visceral pain. PLoS One, 2014, 9(1): e84564.
[6]
Jiang Z, Dinov ID, Labus J, et al. Sex-related differences of cortical thickness in patients with chronic abdominal pain. PLoS One, 2013,8(9): e73932.
[7]
Labus JS, Dinov ID, Jiang Z, et al. Irritable bowel syndrome in female patients is associated with alterations in structural brain networks. Pain, 2014, 155(1): 137-149.
[8]
Chua CS, Bai CH, Shiao CY, et al. Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome. PLoS One, 2017, 12(8): e0183960.
[9]
Chen JY, Blankstein U, Diamant NE, et al. White matter abnormalities in irritable bowel syndrome and relation to individual factors. Brain Res, 2011, 1392(15): 121-131.
[10]
Ellingson BM, Mayer E, Harris RJ, et al. Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. Pain, 2013, 154(9): 1528-1541.
[11]
Irimia A, Labus JS, Torgerson CM, et al. Altered viscerotopic cortical innervation in patients with irritable bowel syndrome. Neurogastroenterol Motil, 2015, 27(8): 1075-1081.
[12]
Niddam DM, Tsai SY, Lu CL, et al. Reduced hippocampal glutamate-glutamine levels in irritable bowel syndrome: preliminary findings using magnetic resonance spectroscopy. Am J Gastroenterol, 2011,106(8): 1503-1511.
[13]
Bruneau EG, Jacoby N, Saxe R. Empathic control through coordinated interaction of amygdala, theory of mind and extended pain matrix brain regions. Neuroimage, 2015, 114: 105-119.
[14]
Liu X, Silverman A, Kern M, et al. Excessive coupling of the salience network with intrinsic neurocognitive brain networks during rectal distension in adoles- cents with irritable bowel syndrome: a preliminary report. Neurogastroenterol Motil, 2016, 28(1): 43-53.
[15]
Larsson MB, Tillisch K, Craig AD, et al. Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome. Gastroenterology, 2012, 142(3): 463-472.
[16]
Elsenbruch S, Rosenberger C, Enck P, et al. Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study. Gut, 2010, 59(4): 489-495.
[17]
Guleria A, Karyampudi A, Singh R, et al. Mapping of brain activations to rectal balloon distension stimuli in male patients with irritable bowel syndrome using functional magnetic resonance imaging. J Neurogastroenterol Motil, 2017, 23(3): 415-427.
[18]
Kano M, Muratsubaki T, Morishita J, et al. Influence of uncertain anticipation on brain responses to aversive rectal distension in patients with irritable bowel syndrome. Psychosom Med, 2017,79(9): 988-999.
[19]
Aizawa E, Sato Y, Kochiyama T, et al. Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling. Gastroenterology, 2012, 143(5): 1188-1198.
[20]
Labus JS, Gupta A, Coveleskie K, et al. Sex differences in emotion-related cognitive processes in irritable bowel syndrome and healthy control subjects. Pain, 2013, 154(10): 2088-2099.
[21]
曾少庆，江桂华，马晓芬,等.肠易激综合征患者静息态下局部脑区神经自发活动及其与HAMA量表评分的相关性.中华神经医学杂志, 2013, 12(7): 719-722.
[22]
Ke J, Qi R, Liu C, et al. Abnormal regional homogeneity in patients with irritable bowel syndrome: A resting-state functional MRI study. Neurogastroenterol Motil, 2015, 27(12): 1796-1803.
[23]
Logothetis NK, Pauls J, Augath M, et al. Neurophysiological investigation of the basis of the fMRI signal. Nature, 2001,412(6843): 150-157.
[24]
马晓芬，江桂华，李淑美,等.肠易激综合征患者静息态功能磁共振成像比率低频振幅研究.中华神经医学杂志, 2014, 13(3):292-295.
[25]
Hong JY, Kilpatrick LA, Labus J, et al. Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain. J Neurosci, 2013, 33(29): 11994-12002.
[26]
Qi R, Liu C, Ke J, et al. Intrinsic brain abnormalities in irritable bowel syndrome and effect of anxiety and depression. Brain Imaging Behav, 2016, 10(4): 1127-1134.
[27]
Letzen JE, Craggs JG, Perlstein WM, et al. Functional connectivity of the default mode network and its association with pain networks in irritable bowel patients assessed via lidocaine treatment. J Pain, 2013, 14(10): 1077-1087.
[28]
Qi R, Ke J, Schoepf UJ, et al. Topological reorganization of the default mode network in irritable bowel syndrome. Mol Neurobiol, 2016, 53(10): 6585-6593.
[29]
Gupta A, Kilpatrick L, Labus J, et al. Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences. Psychosom Med, 2014, 76(6): 404-412.
[30]
Hubbard CS, Hong J, Jiang Z, et al. Increased attentional network functioning related to symptom severity measures in females with irritable bowel syndrome. Neurogastroenterol Motil, 2015, 27(9):1282-1294.
[31]
Weng Y, Qi R, Liu C, et al. Disrupted functional connectivity density in irritable bowel syndrome patients. Brain Imaging Behav, 2016 DOI: .
[32]
Icenhour A, Witt ST, Elsenbruch S, et al. Brain functional connectivity is associated with visceral sensitivity in women with Irritable bowel syndrome. Neuroimage Clin, 2017, 15(2): 449-457.
[33]
Mayberg HS, Silva JA, Brannan SK, et al. The functional neuroanatomy of the placebo effect. Am J Psychiatry, 2002, 159(5):728-737.
[34]
Lee HF, Hsieh JC, Lu CL, et al. Enhanced affect/cognition-related brainresponses during visceral placebo analgesia in irritable bowel syndrome patients. Pain, 2012, 153(6): 1301-1310.
[35]
Schmid J, Langhorst J, Gaß F, et al. Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers. Gut, 2015, 64(3): 418-427.
[36]
Morgan V, Pickens D, Gautam S, et al. Amitriptyline reduces rectal pain-related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut, 2005, 54(5): 601-607.
[37]
Labus JS, Hubbard CS, Bueller J, et al. Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome. Gastroenterology, 2013, 145(6): 1253-1261.
[38]
Pinto-Sanchez MI, Hall GB, Ghajar K, et al. Probiotic bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: A pilot study in patients with irritable bowel syndrome. Gastroenterology, 2017, 153(2): 448-459.
[39]
Lowén MB, Mayer EA, Sjöberg M, et al. Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome. Aliment Pharmacol Ther, 2013, 37(12):1184-1197.
[40]
Zhu Y, Wu Z, Ma X, et al. Brain regions involved in moxibustion-induced analgesia in irritable bowel syndrome with diarrhea: a functional magnetic resonance imaging study. BMC Complement Altern Med, 2014, 16(14): 500.

PREV Application and development of arterial spin labeling technique of magnetic resonance imaging in cerebrovascular disease
NEXT Progress of diffusion tensor imaging in acute spinal cord injury
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn