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Research progress of functional MRI in irritable bowel syndrome
LI Jie  DING Jian-ping 

DOI:10.12015/issn.1674-8034.2017.12.013.


[Abstract] The mechanism of irritable bowel syndrome (IBS) may be related to such factors as visceral hypersensitivity, abnormal intestinal motility, inflammation, psychological factors and so on. However, the symptoms of the disease could explain the lack of morphological changes and biochemical abnormalities. The etiology and pathogenesis of the disease are still unclear. The role of the "brain gut axis" in the pathogenesis of IBS has attracted wide attention and has become a breakthrough point in the study of IBS pathogenesis. Functional magnetic resonance imaging (fMRI) is a noninvasive method detecting neural activity, and has the ability to observe the brain tissue microstructure and functional changes in vivo. FMRI provides a new angle of view for evaluating the central mechanism of "brain gut axis", and also can display the activity of brain and changes in the nerve pathways in IBS patients. In addition, it also has important significance to evaluate the therapeutic effect. This article reviews the present research situation and progress of fMRI in IBS diagnosis and its therapeutic efficacy.
[Keywords] Irritable bowel syndrome；Magnetic resonance imaging；Brain structures；Brain function

LI Jie Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China

DING Jian-ping* Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China

*Corresponding to: Ding JP, E-mail: jpding@vip.sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Public Technology Research and Social Development Projects of Zhejiang province No. 2015C33292
Received  2017-09-20
Accepted  2017-11-13
DOI: 10.12015/issn.1674-8034.2017.12.013
DOI:10.12015/issn.1674-8034.2017.12.013.

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