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• Clinical Article •
Interhemispheric resting state functional connectivity in bipolar Ⅰ euthymia
CHENG Xiao-fang  DENG Wen-hao  CHEN Jian-shan  ZHANG Yi-zhi  ZOU Wen-jin  CUI Li-qian  HUANG Gui-mao  CAO Li-ping 

DOI:10.12015/issn.1674-8034.2018.01.002.


[Abstract] Objective: Abnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder (BD) by recent neuroimaging studies. However, BD-related alterations in interhemispheric functional interaction are still largely unclear. Resting-state functional magnetic resonance imaging (rs-fMRI) approaches, which reveal patterns of coherent spontaneous fluctuations in the fMRI signal, provide a means to quantitatively detect interhemispheric functional interaction pattern. We examined interhemispheric resting-state functional connectivity (RSFC) and its relationships with clinical characteristics in bipolar Ⅰ euthymia using a recently validated approach, voxel-mirrored homotopic connectivity (VMHC).Materials and Methods: Euthymic subjects with bipolar I disorder (n=27) and matched healthy subjects (n=27) underwent resting-state functional magnetic resonance imaging scans. rs-fMRI data were co-registered to the high-resolution T1 symmetric anatomical template, and the homotopic resting state functional connectivity was computed for each subject.Results: Group comparisons revealed that patients exhibited lower VMHC than healthy subjects in inferior frontal gyrus (opercular part), Rolandic operculum, insula, putamen (P<0.05, GRF corrected). Negative correlation was found between the duration of BD and VMHC in the inferior frontal gyrus and Rolandic operculum (r=- 0.402, P=0.037; r=-0.402, P=0.038).Conclusions: These findings suggest substantial impairment of functional coordination between homotopic brain regions in bipolar Ⅰ euthymia. Inferior frontal gyrus and rolandic operculum may have a role in the chronicity of BD.
[Keywords] Bipolar disorder；Euthymia；Resting state；Interhemispheric；Magnetic resonance imaging

CHENG Xiao-fang Department of Radiology, Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hosiptal), Guangzhou 510370, China

DENG Wen-hao Department of Early Intervention, Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hosiptal), Guangzhou 510370, China

CHEN Jian-shan Department of Early Intervention, Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hosiptal), Guangzhou 510370, China

ZHANG Yi-zhi Department of Neurology, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China

ZOU Wen-jin Department of Radiology, Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hosiptal), Guangzhou 510370, China

CUI Li-qian Department of Psychology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China

HUANG Gui-mao Department of Radiology, Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hosiptal), Guangzhou 510370, China

CAO Li-ping* Department of Early Intervention, Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hosiptal), Guangzhou 510370, China

*Correspondence to: Cao LP, E-mail: coolliping@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by major projects of the National Natural Science Foundation No. 91332205 Science and Technology planning projrct of Guangdong province No.2013B021800074
Received  2017-08-28
Accepted  2017-12-06
DOI: 10.12015/issn.1674-8034.2018.01.002
DOI:10.12015/issn.1674-8034.2018.01.002.

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