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• Clinical Article •
Regional homogeneity of white matter lesions in older people with fall risk: a resting state fMRI study
LI Zheng-ran  SHEN Hui-cong  LIN Mei-ying  ZHAN Ya-feng  ZHANG Wei-yi  ZHANG Ning  WANG Chun-xue  MA Jun 

DOI:10.12015/issn.1674-8034.2018.01.003.


[Abstract] Objective: The application of resting state fMRI (rs-fMRI) was used for exploring the regional homogeneity in the aged who had white matter lesions (WMLs) with fall risks.Materials and Methods: The aged more than 60 years old with WMLs were included in study, according to the Tinetti Balance and gait analysis, all patients were divided into experimental group (Tinetti<25) and contrast group (Tinetti≥25). Regional homogeneity (ReHo) values were calculated respectively and correlation analysis was conducted between ReHo values and mini mental state exam (MMSE) and Montreal cognitive assessment (MoCA) extracted from significantly different brain regions.Results: There was statistic significance in the score of MoCA (t=3.881, P< 0.01) and MMSE (t=4.041, P<0.01) between two groups with WMLs. In subjects with risk of falls, the mean ReHo values of left superior frontal gyrus, right middle frontal gyrus, right inferior frontal gyrus decreased, and the mean ReHo values of right middle frontal gyrus, right inferior frontal gyrus were positively correlated with MMSE and MoCA, the mean ReHo values of left superior frontal gyrus was positively correlated with MMSE. The mean ReHo values of right supplementary motor area, left primary motor cortex, left dorsal posterior cingular cortex, left fusiform gyrus, left cerebellum 3, 4, 5, 6 region, right cerebellum 10 region increased, and were negatively correlated with MMSE and MoCA.Conclusions: In subjects with fall risk, the regional homogeneity changed, these differences were correlated with cognitive function.
[Keywords] Accidental falls；Leukoencephalopathies；Magnetic resonance imaging

LI Zheng-ran Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; Medical Imaging Center, Inner Mongolia International Mongolian hospital, Hohhot 010020, China

SHEN Hui-cong* Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

LIN Mei-ying Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

ZHAN Ya-feng Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, The Chinese Academy of Sciences, Beijing 100190, China

ZHANG Wei-yi Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, China

ZHANG Ning Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, China

WANG Chun-xue Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, China

MA Jun Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Shen HC, E-mail: shenhuicong@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by Beijing Municipal Science & Technology Commission Capital Applied Research with Clinical Characteristics No. Z151100004015127 Supported by Beijing Municipal Science & Technology Commission Beijing Brain Research No. Z161100000216131
Received  2017-10-09
Accepted  2017-12-06
DOI: 10.12015/issn.1674-8034.2018.01.003
DOI:10.12015/issn.1674-8034.2018.01.003.

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