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• Clinical Article •
Functional connectivity density alterations at resting state in neuromyelitis optica patients
HAN Yong-liang  LI Yong-mei  LUO Qi  FU Jia-liang  KONG Li-na  XIANG Ya-yun  CHEN Xiao-ya  GU Yao 

DOI:10.12015/issn.1674-8034.2018.01.007.


[Abstract] Objective: Using a novel functional connectivity density (FCD) approach to investigate the strength of intrinsic connectivities alternations in neuromyelitis optica (NMO) patients at resting-state, and the correlation with clincal scores and duration.Materials and Methods: A total of 20 NMO patients and 20 sex- and age-matched healthy controls underwent resting-state functional MRI (rs-fMRI) examinations. Data of rs-fMRI were measured on DPARSFA (based on Matlab station) by using degree centrality method (threshold value was 0.25). Analysis of FCD map between the patient group and the control group were performed by two sample t test (P<0.001, uncorrected, voxels>30). Correlation analysis was performed for regions with FCD value statistically different in NMO with clinical parameters.Results: Compared with the control group, NMO patients showed significantly increased FCD in the left cerebellum crus and decreased FCD in the bilateral frontal lobe (BA 11), bilateral cerebellum 6 and left lingual gyrus. Moreover, the FCD values of the left cerebellum crus was correlated with duration (r=0.6, P=0.005).Conclusions: NMO patients have abnormal brain function network connection properties, which show that the increase or decrease of FCD in multiple brain functional areas may be related to the neuropathologic mechanism of the limb and cognitive dysfunction of NMO patients.
[Keywords] Neuromyelitis optica；Magnetic resonance imaging；Brain functional network；Functional connectivity density

HAN Yong-liang Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

LI Yong-mei* Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

LUO Qi Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

FU Jia-liang Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

KONG Li-na Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

XIANG Ya-yun Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

CHEN Xiao-ya Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

GU Yao Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016

*Correspondence to: Li YM, E-mail: lymzhang70@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was supported by the National Nature Science Foundation of China NO. 81171309 Key Projects in Medical Research of Chongqing Health and Family Planning Commission NO. 2016ZDXM002 Chongqing Health Bureau grant NO. 2012-1-017
Received  2017-08-17
Accepted  2017-10-23
DOI: 10.12015/issn.1674-8034.2018.01.007
DOI:10.12015/issn.1674-8034.2018.01.007.

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