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• Clinical Article •
A research using resting-state fMRI and VBM for HFS
LU Hai-feng  ZHANG Qi-ting  ZHANG Ji-lei  WANG Meng-xing  XU Shuai  QIN Zhao-xia  SHI Yan-hui  HE Xin-wei  DU Xiao-xia  LIU Jian-ren 

DOI:10.12015/issn.1674-8034.2018.01.008.


[Abstract] Objective: Using magnetic resonance imaging technique to explore the change of brain function and structure in patients with hemifacial spasm (HFS).Materials and Methods: This paper combined resting-state functional magnetic resonance imaging (rs-fMRI) and voxel-based morphometry (VBM) to investigate the spontaneous brain activity and structural differences between the 33 patients with HFS and the 33 healthy controls of gender matching. And the MRI data were analyzed by SPSS, SPM12 and Matlab. Two-sample t-tests were used to determine between-group differences and thresholds at P<0.005 (voxel level), and FWE were corrected to P<0.05 at the cluster level. The surviving clusters >30 were reported.Results: Compared to the controls, the patients with HFS exhibited significantly decreased regional homogeneity (ReHo) value in the cerebellum lobule Ⅵ, and decreased gray matter volume in the cerebellum lobule Ⅵ too.Conclusions: Our results showed that patients with HFS exhibited function and structure alteration in the cerebellum lobule Ⅵ, which would play an important role in pathology of HFS.
[Keywords] Hemifacial spasm；Cerebellum；Magnetic resonance imaging；Comparative study

LU Hai-feng Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

ZHANG Qi-ting Department of Neurology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

ZHANG Ji-lei Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

WANG Meng-xing Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

XU Shuai Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

QIN Zhao-xia Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

SHI Yan-hui Department of Neurology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

HE Xin-wei Department of Neurology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

DU Xiao-xia* Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

LIU Jian-ren* Department of Neurology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

*Correspondence to: Du XX, E-mail: xxdu@phy.ecnu.edu.cn Liu JR, E-mail: liujr021@sjtu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This research was supported by grants from the National Natural Science Foundation of China No. 81571658 Research Innovation Project from Shanghai Municipal Science and Technology Commission No. 14JC1404300 The "prevention and control of chronic diseases project" of Shanghai Hospital Development Center No. SHDC12015310 Project from Shanghai Municipal Education Commission: Gaofeng Clinical Medicine Grant Support No. 20161422 Clinical Research Project from Shanghai Jiaotong University School of Medicine No. DLY201614 Biomedicine Key Program from Shanghai Municipal Science and Technology Commission No. 16411953100
Received  2017-09-06
Accepted  2017-11-18
DOI: 10.12015/issn.1674-8034.2018.01.008
DOI:10.12015/issn.1674-8034.2018.01.008.

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