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• Clinical Article •
Diffusion tensor imaging to evaluate the value of treatment with cervical perivascular sympathectomy in children with cerebral palsy
DONG Shuang-jun  WANG Yun-ling  WANG Hong  DENG Jia-min  JIA Wen-xiao 

DOI:10.12015/issn.1674-8034.2018.01.009.


[Abstract] Objective: To explpore the value of magnetic resonance diffusion tensor imaging (DTI) and diffusion tensor tracking (DTT), on evaluating the cerebral white matter recovery in children with cerebral palsy after cervical perivascular sympathectomy.Materials and Methods: Thirty children with hemiplegic cerebral palsy accepted clinical assessment and routine MRI and DTI examination before and after operation. The fractional anisotropy (FA) values for the regions including internal capsule and cerebral peduncle in the preoperative operation side and the opposite side, preoperative and postoperative, were measured and compared. 3D reconstruction of white matter tracts was employed. The gross motor function classification system (GMFCS) was used to evaluate the movement function of cerebral palsy in children. Paired sample t test was performed to compare the differences of FA values between the preoperative operation side and the lateral, preoperative and postoperative white matter. Spearman relativity analysis was performed to assess correlation between DTI parameters in different white matter fiber bundles and GMFCS in patients.Results: The FA values of white matter fiber bundle in different parts of the preoperative operation side were significantly lower of the preoperative contralateral, the differences were statistically significant (P<0.01). Compared to preoperative, the FA values of white matter fiber bundle in different parts of the operation side were significantly increased in the six months after surgery (P<0.01), the gross motor function had been improved. There was no statistically significant difference between the six months after surgery and the preoperative period of the FA value of white matter fiber bundles in different parts of the contralateral (P>0.05). The clinical GMFCS in the patients were negatively correlated with the FA values (P<0.01). Moreover, the relativity between the GMFCS and the FA value of internal capsule and cerebral peduncle were both higher (r=-0.933, P<0.01; r=-0.873, P<0.01).Conclusions: DTI combined with DTT can be used to quantitatively evaluate the postoperative recovery of white matter in children with cerebral palsy; it plays an important role in adjuvant clinical treatment and prognosis assessment.
[Keywords] Cerebral palsy；Diffusion tensor imaging；Cervical perivascular sympathectomy

DONG Shuang-jun Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

WANG Yun-ling Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

WANG Hong Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

DENG Jia-min Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

JIA Wen-xiao* Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

*Correspondence to: Jia WX, E-mail: jwxxj@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Natural Science Foundation of China No. 81660202
Received  2017-08-12
Accepted  2017-10-23
DOI: 10.12015/issn.1674-8034.2018.01.009
DOI:10.12015/issn.1674-8034.2018.01.009.

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