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• Clinical Article •
The diagnostic performance of hepatocyte-specific Gadoxetic acid disodium (Gd-EOB-DTPA) for detection of small hepatocellular carcinoma: a Meta-analysis
FENG Zhi-chao  LIAO Yun-jie  LIANG Qi  RONG Peng-fei 

DOI:10.12015/issn.1674-8034.2018.01.010.


[Abstract] Objective: To systematically review the diagnostic performance of hepatocyte-specific Gd-EOB-DTPA for small hepatocellular carcinoma (sHCC).Materials and Methods: The diagnostic tests which were used to evaluate the diagnostic performance of Gd-EOB-DTPA for sHCC, were searched and collected in several databases including PubMed, Web of Science, Embase, CNKI, CBM, Wanfang Data and VIP from January 2008 to February 2017. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was performed by using Stata 12.0 software.Results: A total of 12 studies from four countries were included, involving 1685 hepatic nodules in 1127 patients. The results showed that, the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and corresponding 95% confidence interval of Gd-EOB-DTPA for sHCC were 0.95 (0.91, 0.97), 0.90 (0.83, 0.95), 9.84 (5.60, 17.28), 0.06 (0.03, 0.10), and 166.39 (73.66, 375.84), respectively. The area under curve of summary receiver operating characteristic (SROC) was 0.98 (0.96, 0.99). The results of subgroup analysis suggested that sample size was a significant factor that influenced the diagnostic specificity of EOB-MRI for sHCC (P< 0.01).Conclusions: Hepatocyte-specific Gd-EOB-DTPA is of highly value for diagnosis of sHCC, which deserves to be recommended for clinical practice in early detection and diagnosis. Further studies with larger sample size are in demand for improving the diagnostic specificity.
[Keywords] Contrast media；Carcinoma, hepatocellular；Meta-analysis；Diagnosis

FENG Zhi-chao Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

LIAO Yun-jie Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

LIANG Qi* Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

RONG Peng-fei Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

*Correspondence to: Liang Q, Email: csuliangqi10@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the Key Research and Development Project of Hunan Province, China No. 2015SK20664
Received  2017-08-25
Accepted  2017-11-18
DOI: 10.12015/issn.1674-8034.2018.01.010
DOI:10.12015/issn.1674-8034.2018.01.010.

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