Share：
Share this content in WeChat
X
[Chinese][PDF]912172
• Clinical Article •
Resting-state functional connectivity of striatum in Parkinson's disease
MA Lai-yang  CAO Jing  LIU Guang-yao  ZHANG Jing 

DOI:10.12015/issn.1674-8034.2018.02.001.


[Abstract] Objective: To explore the functional connectivity changes in patients with Parkinson's disease (PD) by blood-oxygen-level dependent functional magnetic resonance imaging (BOLD-fMRI).Materials and Methods: Twenty normal control (NC) and thirty-five PD patients, who were examined with resting state fMRI. Selecting the bilateral striatum areas as the seed voxels. Two sample t test was used to compare the differences of L-STR and R-STR between PD group and NC group.Results: (1)L-STR: Compared to NC group, the positive functional connectivity of bilateral posterior cingulate cortex, right dorsolateral prefrontal cortex, left, posterior central gyrus, inferior parietal lobule, left precuneus, were decreased and the inferior frontal gyrus, parahippocampal gyrus, left hippocampus, left insula were increased in the PD group (P<0.05, AlphaSim corrected). (2)R-STR: Compared to NC group, the positive functional connectivity of bilateral posterior cingulate cortex, dorsolateral prefrontal cortex were decreased and the right lingual gyrus, insular lobe, parahippocampal gyrus, bilateral hippocampus, left thalamus, were increased in PD group (P<0.05, AlphaSim corrected).Conclusions: PD patients have abnormal brain functional connectivity network in resting state.
[Keywords] Parkinson disease；Corpus striatum；Magnetic resonance imaging, functional；Seed voxels；Functional connection

MA Lai-yang Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

CAO Jing Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

LIU Guang-yao Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

ZHANG Jing* Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

*Correspondence to: Zhang J, E-mail: lztong2001@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Gansu Province Natural Science Foundation No.1506RJYA218
Received  2017-02-18
Accepted  2017-11-22
DOI: 10.12015/issn.1674-8034.2018.02.001
DOI:10.12015/issn.1674-8034.2018.02.001.

[1]
Aarabi MH, Kamalian A, Mohajer B, et al. A statistical approach in human brain connectome of Parkinson disease in elderly people using Network Based Statistics//Conf Proc IEEE Eng Med Biol Soc. Conf Proc IEEE Eng Med Biol Soc, 2015: 4310.
[2]
Liu S, Cai W, Liu S, et al. Multimodal neuroimaging computing: a review of the applications in neuropsychiatric disorders. Brain Informatics, 2015, 2(3): 167-180.
[3]
Hughes AJ, Daniel SE, Kilford L, et al. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry, 1992, 55(3): 181-184.
[4]
Song XW, Dong ZY, Long XY, et al. REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One, 2011, 6(9): e25031.
[5]
Friston KJ, Frith CD, Liddle PF, et al. Functional connectivity: the principal-component analysis of large (PET) data sets. J Cereb Blood Flow Metab, 1993, 13(1): 5.
[6]
Frcs HA, Wu CY, Foltynie T, et al. 1-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease. Mov Disord, 2017, 32(6): 874.
[7]
Papma JM, Smits M, Groot MD, et al. The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment. Eur Radiol, 2017, 27(9): 3716-3724.
[8]
Kenny ER, Blamire AM, Firbank MJ, et al. Functional connectivity in cortical regions in dementia with lewy bodies and Alzheimer's disease. Brain, 2012, 135(2): 569-581.
[9]
Zeighami Y, Ulla M, Iturria-Medina Y, et al. Network structure of brain atrophy in de novo Parkinson's disease. Elife, 2015(4): e08440.
[10]
Bell PT, Gilat M, O'Callaghan C, et al. Dopaminergic basis for impairments in functional connectivity across subdivisions of the striatum in Parkinson's disease. Hum Brain Mapp, 2015, 36(4): 1278.
[11]
Yang W, Liu B, Huang B, et al. Altered resting-state functional connectivity of the striatum in Parkinson's disease after levodopa administration. PLoS One, 2016, 11(9): e0161935.
[12]
Postuma RB, Dagher A. Basal ganglia functional connectivity based on a meta-analysis of 126 positron emission tomography and functional magnetic resonance imaging publications. Cereb Cortex, 2006, 16(10): 1508-1521.
[13]
Gu HY, Sun XJ, Lu Y, et al. Magnetic resonance imaging of amygdala functional connectivity in early Parkinson's disease in the resting-state. J Clin Radiol, 2017, 36(9): 1218-1223.谷何一，孙学进，鲁毅，等．静息态下早期帕金森病患者杏仁核功能连接的MRI研究.临床放射学杂志, 2017, 36(9): 1218-1223.
[14]
Zhang S, Hu S, Chao HH, et al. Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study. Brain Structure & Function, 2017, 222(6): 2573-2583.
[15]
Luo C, Song W, Chen Q, et al. Reduced functional connectivity in early-stage drug-naive Parkinson's disease: a resting-state fMRI study. Neurobiol Aging, 2014, 35(2): 431.
[16]
Zhang YQ, Wu HZ, Guan JT, et al. Metabolic assessment of Parkinson disease by magnetic resonance spectroscopy. Chin J Magn Reson Imag, 2016, 7(5): 353-358.张尤桥，吴焕泽，关计添，等．帕金森病患者脑部氢质子MR波谱研究．磁共振成像, 2016, 7(5): 353-358.
[17]
Gasca-Salas C, García-Lorenzo D, Garcia-Garcia D, et al. Parkinson' s disease with mild cognitive impairment: severe cortical thinning antedates dementia. Brain Imaging & Behavior, 2017, 14. DOI: 10.1007/s11682-017-9751-6.
[18]
Karagulle-Kendi A, Lehericy SM, Ugurbil K, et al. Altered diffusion in the frontal lobe in Parkinson disease. AJNR Am J Neuroradiol, 2008, 29(3): 501-505.
[19]
Gesquièredando A, Guedj E, Loundou A, et al. A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation. Movement Disorders, 2016, 30(13): 1767-1776.
[20]
Chen Z, Chen X, Liu M, et al. Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study. J Headache Pain, 2016, 17(1): 89.
[21]
Baggio HC, Segura B, Sala-Llonch R, et al. Cognitive impairment and resting-state network connectivity in Parkinson's disease. Hum Brain Mapp, 2015, 36(1): 199-212.
[22]
Manza P, Zhang S, Li CS, et al. Resting-state functional connectivity of the striatum in early-stage Parkinson's disease: Cognitive decline and motor symptom tolog=y. Hum Brain Mapp, 2016, 37(2): 648-662.
[23]
Beauchamp MH, Dagher A, Panisset M, et al. Neural substrates of cognitive skill learning in Parkinson' s disease. Brain & Cognition, 2008, 68(2): 134-143.

PREV Locating the coordinates of globus pallidus internus using MR imaging-based method in Parkinson,s disease surgery
NEXT The study of cerebral white matter change in children with new-onset, untreated idiopathic generalized epilepsy by using magnetic resonance imaging
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn