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• Clinical Article •
Resting-state functional connectivity of striatum in Parkinson's disease
MA Lai-yang  CAO Jing  LIU Guang-yao  ZHANG Jing 

DOI:10.12015/issn.1674-8034.2018.02.001.


[Abstract] Objective: To explore the functional connectivity changes in patients with Parkinson's disease (PD) by blood-oxygen-level dependent functional magnetic resonance imaging (BOLD-fMRI).Materials and Methods: Twenty normal control (NC) and thirty-five PD patients, who were examined with resting state fMRI. Selecting the bilateral striatum areas as the seed voxels. Two sample t test was used to compare the differences of L-STR and R-STR between PD group and NC group.Results: (1)L-STR: Compared to NC group, the positive functional connectivity of bilateral posterior cingulate cortex, right dorsolateral prefrontal cortex, left, posterior central gyrus, inferior parietal lobule, left precuneus, were decreased and the inferior frontal gyrus, parahippocampal gyrus, left hippocampus, left insula were increased in the PD group (P<0.05, AlphaSim corrected). (2)R-STR: Compared to NC group, the positive functional connectivity of bilateral posterior cingulate cortex, dorsolateral prefrontal cortex were decreased and the right lingual gyrus, insular lobe, parahippocampal gyrus, bilateral hippocampus, left thalamus, were increased in PD group (P<0.05, AlphaSim corrected).Conclusions: PD patients have abnormal brain functional connectivity network in resting state.
[Keywords] Parkinson disease；Corpus striatum；Magnetic resonance imaging, functional；Seed voxels；Functional connection

MA Lai-yang Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

CAO Jing Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

LIU Guang-yao Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

ZHANG Jing* Department of Magnetic Resonance, the Second Hospital Affiliated Lanzhou University, Lanzhou 730020, China

*Correspondence to: Zhang J, E-mail: lztong2001@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Gansu Province Natural Science Foundation No.1506RJYA218
Received  2017-02-18
Accepted  2017-11-22
DOI: 10.12015/issn.1674-8034.2018.02.001
DOI:10.12015/issn.1674-8034.2018.02.001.

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