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• Clinical Article •
The study of cerebral white matter change in children with new-onset, untreated idiopathic generalized epilepsy by using magnetic resonance imaging
MEI Lan  LONG Ran  TANG Guang-cai  HAN Fu-gang  DIAO Xian-ming  CHEN Hong-liang  QIU Li-hua 

DOI:10.12015/issn.1674-8034.2018.02.002.


[Abstract] Objective: Microstructural change of idiopathic generalized epilepsies (IGE) has been widely reported in children and adult patients. However, previous studies were focused on the chronic patients with antiepileptic drugs. This study aims at using the diffusion tensor imaging (DTI) technique to investigate the structural abnormalities of white matter in children with new onset, untreated IGE patients.Materials and methods: A total of 45 IGE patients (age range: 5—18 years, males: females=26:19) and 32 healthy controls (age range: 5—18 years, males: females=21:11) were included in our present study. Voxel-based analysis was used to compare the differences between patients and controls. Pearson correlation was used to investigate the relationship between altered DTI metrics and clinical parameters.Results: After family-wise error (FWE) correction, only the parameter of mean diffusivity (MD) showed decreased value in left paracentral lobule, right precuneus and right superior parietal lobule in IGE patients. If using AlphaSim correction, increased fractional anisotropy (FA) were found in the white matter of bilateral prefrontal lobe in children with first-onset, untreated IGE patients. There is no correlation between the changed MD/FA values with the clinical parameters.Conclusions: The findings indicate that microstructural impairments exist in children with new onset, untreated IGE. MD may be more sensitive to detect the microstructural change in the early stage of IGE. The increased FA and decreased MD may be a meaningful indicator of the initiating or compensatory mechanisms of IGE prior to cognitive decline.
[Keywords] Magnetic resonance imaging；White matter fiber；Epilepsy；Adolescent

MEI Lan Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

LONG Ran Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

TANG Guang-cai Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

HAN Fu-gang Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

DIAO Xian-ming Department of Radiology, the Second People's Hospital of Yibin, Yibin 644000, China

CHEN Hong-liang Department of Radiology, the Second People's Hospital of Yibin, Yibin 644000, China

QIU Li-hua* Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Department of Radiology, the Second People's Hospital of Yibin, Yibin 644000, China

*Corresponding to: Qiu LH, E-mail: 283708370@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of the Key Projects of Science and Technology Bureau of Yibin No. 2013SF009
Received  2017-09-26
Accepted  2017-10-27
DOI: 10.12015/issn.1674-8034.2018.02.002
DOI:10.12015/issn.1674-8034.2018.02.002.

[1]
Ngugi AK, Bottomley C, Kleinschmidt I, et al. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia, 2010, 51(5): 883-890.
[2]
Marini C, King MA, Archer JS, et al. Idiopathic generalised epilepsy of adult onset: clinical syndromes and genetics. J Neurol Neurosurg Psychiatry, 2003, 74(2): 192-796.
[3]
Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 1989, 30(4): 389-399.
[4]
Yogarajah M, Duncan JS. Diffusion-based magnetic resonance imaging and tractography in epilepsy. Epilepsia, 2008, 49(2): 189-200.
[5]
Povlishock JT, Katz DI. Update of neuropathology and neurological recovery after traumatic brain injury. J Head Trauma Rehabil, 2005, 20(1): 76-94.
[6]
Zhang Y, Liu H, Wang L, et al. Relationship between functional connectivity and motor function assessment in stroke patients with hemiplegia: a resting-state functional MRI study. Neuroradiology, 2016, 58(5): 503-511.
[7]
Alfradique I, Vasconcelos MM. Juvenile myoclonic epilepsy. Arq Neuropsiquiatr, 2007, 65(4B): 1266-1271.
[8]
Jiang S, Luo C, Liu Z, et al. Altered local spontaneous brain activity in juvenile myoclonic epilepsy: A preliminary resting-state fMRI study. Neural Plast, 2016, 2016: 1-7.
[9]
Kim SH, Lim SC, Kim W, et al. Extrafrontal structural changes in juvenile myoclonic epilepsy: a topographic analysis of combined structural and microstructural brain imaging. Seizure, 2015, 30(8): 124-131.
[10]
Li Q, Cao W, Liao X, et al. Altered resting state functional network connectivity in children absence epilepsy. J Neurol Sci, 2015, 354(1-2): 79-85.
[11]
Liu F, Wang Y, Li M, et al. Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic-clonic seizure. Hum Brain Mapp, 2017, 38(2): 957-973.
[12]
Yang T, Fang Z, Ren J, et al. Altered spontaneous activity in treatment-naive childhood absence epilepsy revealed by Regional Homogeneity. J Neurol Sci, 2014, 340(1-2): 58-62.
[13]
Qiu W, Gao Y, Yu C, et al. Structural abnormalities in childhood absence epilepsy: voxel-based analysis using diffusion tensor imaging. Front Hum Neurosci, 2016, 10(9): 483.
[14]
Clemens B, Puskás S, Besenyei M, et al. EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes. Epilepsy Res, 2012, 99(3): 281-292.
[15]
Bittar RG, Andermann F, Olivier A, et al. Interictal spikes increase cerebral glucose metabolism and blood flow: a PET study. Epilepsia, 1999, 40(2): 170-178.
[16]
Alexander AL, Hurley SA, Samsonov AA, et al. Characterization of cerebral white matter properties using quantitative magnetic resonance imaging stains. Brain Connect, 2011, 1(6): 423-446.
[17]
Gotman J, Grova C, Bagshaw A, et al. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc Natl Acad Sci U S A, 2005, 102(42): 15236-15240.
[18]
Papadakis NG, Xing D, Houston GC, et al. A study of rotationally invariant and symmetric indices of diffusion anisotropy. Magn Reson Imaging, 1999, 17(6): 881-892.
[19]
Nazem-Zadeh MR, Schwalb JM, Elisevich KV, et al. Lateralization of temporal lobe epilepsy using a novel uncertainty analysis of MR diffusion in hippocampus, cingulum, and fornix, and hippocampal volume and FLAIR intensity. J Neurol Sci, 2014, 342(1-2): 152-161.
[20]
Widjaja E, Kis A, Go C, et al. Abnormal white matter on diffusion tensor imaging in children with new-onset seizures. Epilepsy Res, 2013, 104(1-2): 105-111.
[20]
Kori P, Garg RK, Malhotra HS, et al. Evaluation of cerebral white-matter micro-structural alterations in patients with medically refractory epilepsy using diffusion tensor tractography. Epilepsy Res, 2013, 107(1-2): 82-90.
[21]
Xiao F, Chen Q, Yu X, et al. Hemispheric lateralization of microstructural white matter abnormalities in children with active benign childhood epilepsy with centrotemporal spikes (BECTS): a preliminary DTI study. J Neurol Sci, 2014, 336(1-2): 171-179.
[22]
Kim SE, Lee JH, Chung HK, et al. Alterations in white matter microstructures and cognitive dysfunctions in benign childhood epilepsy with centrotemporal spikes. Eur J Neurol, 2014, 21(5): 708-717.
[23]
Ekmekci B, Bulut HT, Gümüştaş F, et al. The relationship between white matter abnormalities and cognitive functions in new-onset juvenile myoclonic epilepsy. Epilepsy Behav, 2016, 62(7): 166-170.

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