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• Clinical Article •
Using multiparametric MRI to differentiate uterine leiomyosarcoma from atypical leiomyoma
BI Qiu  LÜ Fa-jin  XIAO Zhi-bo  ZOU Chun-xia  SHEN Yi-qing  LIU Xiao-shuang 

DOI:10.12015/issn.1674-8034.2018.02.006.


[Abstract] Objective: To explore the diagnostic value of clinical parameters and qualitative and quantitative magnetic resonance imaging (MRI) features in distinguishing uterine leiomyosarcoma (LMS) from atypical leiomyoma (ALM).Materials and Methods: From June 2011 to December 2016, clinical data of 19 LMSs and 88 ALMs confirmed by pathology was collected in our hospital. Twelve LMSs and 79 ALMs underwent MRI scan before surgery and met the conditions. Analyzing and comparing the differences in MRI qualitative features, diffusion weighted imaging (DWI), and dynamic contrast-enhanced parameters between LMS and ALM.Results: There were significant differences between LMS and ALM in the following qualitative MRI parameters: LMS was mainly located in the uterine cavity with an ill-defined margin, showed heterogeneous signal on T2WI and hyperintensity on DWI, no enhancement region was in the center of the tumor on contrast-enhanced MRI (P<0.05). For quantitative MRI parameters, mean apparent diffusion coefficient (mADC) values, early enhancement ratio (EER), maximum contrast enhancement ratio (MCER) of the solid component of LMS could help to distinguish from ALM (P< 0.05). According to receiver operating characteristic (ROC) curves, when the cut-off values of mADC was 1.09×10-3 mm2/s, the sensitivity and specificity were 97.5% and 75.0%.Conclusions: It was valuable to use multiparametric MRI to differentiate LMS from ALM.
[Keywords] Leiomyosarcoma；Hysteromyoma；Magnetic resonance imaging

BI Qiu Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LÜ Fa-jin* Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

XIAO Zhi-bo Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZOU Chun-xia Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

SHEN Yi-qing Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LIU Xiao-shuang Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

*Correspondence to: Lü FJ, E-mail: fajinlv@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Prior Clinical Specialization Building Project No.2013544
Received  2017-11-16
Accepted  2018-01-05
DOI: 10.12015/issn.1674-8034.2018.02.006
DOI:10.12015/issn.1674-8034.2018.02.006.

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