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• Clinical Article •
Assessment of diffusion kurtosis imaging in lumbar intervertebral disc degeneration
ZENG Fei-fei  ZHA Yun-fei  HU Lei  LIN Yuan  GONG Wei  CHEN Pian-pian  LIU Bai-yu  LU Xue-song 

DOI:10.12015/issn.1674-8034.2018.02.007.


[Abstract] Objective: To investigate the value of diffusion kurtosis imaging (DKI) related parameters in assessing lumbar intervertebral disc degeneration.Materials and Methods: T2WI and DKI were performed on 81 subjects. DKI related parameters: mean kurtosis (MK) and mean diffusivity (MD) of nucleus pulposus (NP) were measured and correlated with Pfirrmann grades, disc level, and gender. ANOVA and post hoc tests were employed to compare MK and MD values of different Pfirrmann grades, as well as the values in different disc levels. Associations between MK, MD values and Pfirrmann grades were tested using Spearman rank correlation. Two-sample t-test was applied for the gender differences.Results: Pfirrmann grades were positively correlated with MK values (r=0.922, P<0.01) and negatively correlated with MD values (r=-0.921, P<0.01) in the NP. MK value in L5/S1 level (0.89±0.32) was higher than that in L1/L2 (0.82±0.14) and L2/L3 (0.84±0.23) (P<0.05) level, MD value in L5/S1 level (1.83±0.30) was lower than that in L1/L2 (1.89±0.14) and L2/L3 (1.86±0.19) (P<0.05) level. There was no statistical significances in MK and MD values of each level between males and females (P>0.05).Conclusions: DKI is feasible to assess early lumbar intervertebral disc degeneration. MK and MD values are correlated with Pfirrmann grades and spinal level, and have no correlation with gender.
[Keywords] Intervertebral disc degeneration；Lumbar vertebrae；Diffusion kurtosis imaging；Magnetic resonance imaging

ZENG Fei-fei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yun-fei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Wuhan 430060, China

HU Lei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIN Yuan Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

GONG Wei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

CHEN Pian-pian Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIU Bai-yu Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LU Xue-song Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Wuhan 430060, China; Department of Biological Engineering, School of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail: zhayunfei999@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment No. PJS140011511
Received  2017-08-01
Accepted  2017-09-06
DOI: 10.12015/issn.1674-8034.2018.02.007
DOI:10.12015/issn.1674-8034.2018.02.007.

[1]
Chen XC, Liu M, He D, et al. Magnetic resonance imaging study of disc low back pain. Natl Med J China, 2014, 94(25): 933-935.陈兴灿，刘淼，何东，等．椎间盘源性下腰痛的MRI观察．中华医学杂志, 2014, 94(25): 933-935.
[2]
Jensen JH, Helpern JA, Ramani A, et al. Diffusion kurtosis imaing: the quantification of non: Gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med, 2005, 53(6): 1432-1440.
[3]
Jensen JH, Helpern JA. MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed, 2010, 23(7): 698-710.
[4]
Bai Y, Lin Y, Tian J, et al. Grading of gliomas by using monoexponential, biexponential, and stretched exponential diffusion-weighted MR imaging and diffusion kurtosis MR imaging. Radiology, 2016, 278(2): 496-504.
[5]
Raab P, Hattingen E, Frankz K, et al. Cerbral gliomas: diffusional kurtosis imaging analysis of micro structural differences. Radiology, 2010, 254(3): 876-881.
[6]
Yan K, Hu SS, Yang P, et al. Research progress of diffusional kurtosis imaging in tumour. Chin J Magn Reson Imaging, 2016, 7(8): 635-640.闫坤，胡莎莎，杨品，等．磁共振扩散峰度成像在肿瘤中的研究进展．磁共振成像, 2016, 7(8): 635-640.
[7]
Pfirrmann CW, Metzdorf A, Zanetti M, et al. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine, 2001, 26(17): 1873-1878.
[8]
Rosenkrantz AB, Padhani AR, Chenevert TL, et al. Body diffusion kurtosis imaging: Basic principles, applications, and considerations for clinical practice. J Magn Reson Imaging, 2015, 42(5): 1190-1202.
[9]
Eguchi Y, Oikawa Y, Suzuki M, et al. Diffusion tensor imaging of radiculopathy in patients with lumbar disc herniation: preliminary results. Bone Joint J, 2016, 98(3): 387-394.
[10]
Li L, Zhu WZ, Chen WW, et al. The study of the intervertebral disc microstructure in matured rats with diffusion kurtosis imaging. Magn Reson Imaging, 2017, 42: 101-106.
[11]
Katsura M, Suzuki Y, Hata J, et al. Non-gaussian diffusion-weighted imaging for assessing diurnal changes in intervertebral disc microstructure. J Magn Reson Imaging, 2014, 40(5): 1208-1214.
[12]
Zhu TT, Li T, Zhang YS, et al. MR apparent diffusion coefficient of the normal lumbar intervertebral discs: its changes in the morning and in the evening. J Clin Radiol, 2014, 33(10): 1567-1570.祝婷婷，李涛，张淯淞，等．正常腰椎间盘MR弥散的早晚变化．临床放学杂志, 2014, 33(10): 1567-1570.
[13]
Liu YS, Chen QX, Li FC, et al. The influence of endplate concave angle on the mechanical response of lumbar motion segment: a finite element analysis. Chin J Clin Anat, 2007, 25(2): 207-211．刘耀升，陈其昕，李方财，等．终板凹陷角变化对腰椎运动节段生物力学影响的有限元分析．中国临床解剖学杂志, 2007, 25(2): 207-211．
[14]
Zhang W, Ma XH, Wang Y, et al. Assessment of apparent diffusion coefficient in lumbar intervertebral disc degeneration. Eur Spine J, 2014, 23(9): 1830-1836.
[15]
Siemionow K, An H, Masuda K, et al. The effects of age, sex, ethnicity, and spinal level on the rate of intervertebral disc degeneration: a review of 1712 intervertebral discs. Spine (Phila Pa 1976), 2011, 36(17): 1333-1339.
[16]
Wang YX, Griffith JF. Effect of menopause on lumbar disc degeneration: potential etiology. Radiology, 2010, 257(2): 318-320.

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