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• Clinical Article •
Assessment of diffusion kurtosis imaging in lumbar intervertebral disc degeneration
ZENG Fei-fei  ZHA Yun-fei  HU Lei  LIN Yuan  GONG Wei  CHEN Pian-pian  LIU Bai-yu  LU Xue-song 

DOI:10.12015/issn.1674-8034.2018.02.007.


[Abstract] Objective: To investigate the value of diffusion kurtosis imaging (DKI) related parameters in assessing lumbar intervertebral disc degeneration.Materials and Methods: T2WI and DKI were performed on 81 subjects. DKI related parameters: mean kurtosis (MK) and mean diffusivity (MD) of nucleus pulposus (NP) were measured and correlated with Pfirrmann grades, disc level, and gender. ANOVA and post hoc tests were employed to compare MK and MD values of different Pfirrmann grades, as well as the values in different disc levels. Associations between MK, MD values and Pfirrmann grades were tested using Spearman rank correlation. Two-sample t-test was applied for the gender differences.Results: Pfirrmann grades were positively correlated with MK values (r=0.922, P<0.01) and negatively correlated with MD values (r=-0.921, P<0.01) in the NP. MK value in L5/S1 level (0.89±0.32) was higher than that in L1/L2 (0.82±0.14) and L2/L3 (0.84±0.23) (P<0.05) level, MD value in L5/S1 level (1.83±0.30) was lower than that in L1/L2 (1.89±0.14) and L2/L3 (1.86±0.19) (P<0.05) level. There was no statistical significances in MK and MD values of each level between males and females (P>0.05).Conclusions: DKI is feasible to assess early lumbar intervertebral disc degeneration. MK and MD values are correlated with Pfirrmann grades and spinal level, and have no correlation with gender.
[Keywords] Intervertebral disc degeneration；Lumbar vertebrae；Diffusion kurtosis imaging；Magnetic resonance imaging

ZENG Fei-fei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yun-fei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Wuhan 430060, China

HU Lei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIN Yuan Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

GONG Wei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

CHEN Pian-pian Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIU Bai-yu Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LU Xue-song Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Wuhan 430060, China; Department of Biological Engineering, School of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail: zhayunfei999@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment No. PJS140011511
Received  2017-08-01
Accepted  2017-09-06
DOI: 10.12015/issn.1674-8034.2018.02.007
DOI:10.12015/issn.1674-8034.2018.02.007.

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