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• Clinical Article •
The correlation between brain MR amide proton imaging and scores of clinical psychometric scales in patients with Alzheimer's disease
WANG Rui  BAN Yun-qing  LI Chun-mei  LOU Bao-hui  ZHANG Chen  CHEN Min 

DOI:10.12015/issn.1674-8034.2018.03.001.


[Abstract] Objective: To evaluate the correlation between MR amide proton transfer (APT) imaging values of cerebral structures and neuropsychological scores in patients with Alzheimer's disease (AD).Materials and Methods: Twenty-one AD patients and 19 age- and sex- matched normal controls underwent APT and structural MR imaging. The magnetic resonance ratio asymmetry (MTRasym) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions and cerebral peduncles were measured on the oblique axial APT images. All the subjects were evaluated by Mini-Mental State Examination (MMSE) and clinical dementia rating (CDR). MTRasym (3.5 ppm) values of the cerebral structures between two groups were compared with independent-samples t test. Controlling for age and years of education, partial correlation analysis was used to investigate the correlation between the various MR imaging measures and MMSE, CDR scores among all the subjects.Results: Compared to normal controls, MTRasym (3.5 ppm) in bilateral hippocampi were significantly increased in AD patients [right: (0.86±0.32)% and (1.42±0.35)%, t=5.158, P=0.000; left: (0.84±0.31)% and (1.39±0.33)%. t=5.225, P=0.000]. MTRasym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE scores (right r=-0.637, P=0.000. left r=-0.611, P=0.000) and positively correlated with CDR scores (right r=0.686, P=0.000. left r=0.658, P=0.000).Conclusions: APT imaging can show sensitively hippocampal abnormal metabolite based on increased proteins and peptides in patients with AD, which suggests the technique is a useful tool to diagnose AD and monitor the disease.
[Keywords] Alzheimer's disease；Hippocampus；Magnetic resonance imaging

WANG Rui Department of Radiology, Beijing Hospital, Beijing 100730, China

BAN Yun-qing Xinjiang Medical University Fifth Hospitall, Wulumuqi 830011, China

LI Chun-mei Department of Radiology, Beijing Hospital, Beijing 100730, China

LOU Bao-hui Department of Radiology, Beijing Hospital, Beijing 100730, China

ZHANG Chen Department of Radiology, Beijing Hospital, Beijing 100730, China

CHEN Min* Department of Radiology, Beijing Hospital, Beijing 100730, China

*Correspondence to: Chen M, E-mail: cjr.chenmin@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This research is funded by the National Natural Science Foundation of China No. 81771826, 81361120392 and 81401404 Beijing Natural Science Foundation No. 7162171 Beijing Hospital level No. bj-2015-142
Received  2017-09-29
Accepted  2018-01-30
DOI: 10.12015/issn.1674-8034.2018.03.001
DOI:10.12015/issn.1674-8034.2018.03.001.

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