Share：
Share this content in WeChat
X
[Chinese][PDF]107770
• Clinical Article •
Dynamic contrast enhanced MRI for pancreatic perfusion in acute pancreatitis
HU Ran  CHEN Yong  XIE Chao-lian  TANG Meng-yue  ZENG Nan-lin  CHEN Tian-wu  ZHANG Xiao-ming  LI Xin 

DOI:10.12015/issn.1674-8034.2018.03.007.


[Abstract] Objective: To study dynamic contrast enhanced MRI (DCE-MRI) for the normal pancreas and acute pancreatitis (AP).Materials and Methods: The institutional review board approved the study, written informed consent was obtained. Twenty patients without any pancreatic disorders (control group) and forty five patients with clinically proved AP were recruited in this study. All patients had performed MRI with T1WI, T2WI, fat suppression T2WI sequences, multiple flip angle T1WI-LAVA and T1WI-LAVA dynamic contrast enhanced scan sequence. The OmitkDCEMRITool of Omni-Kinetics Version V2.0.10 (GE) was used to analyze the multiple flip angles T1WI-LAVA and T1WI-LAVA dynamic contrast enhanced imagings. The Ktrans, Vp and AUC values were measured in both AP group and Control group. The perfusion parameters of the head, body and tail of normal pancreas were compared by using the Wilcoxon singned-rank test, and the perfusion parameters of AP group and Control group were compared by Wilcoxon rank sum test.Results: The Ktrans, Vp and AUC values of AP were (0.417, 0.132- 0.746) ml/min, (0.058, 0.028—0.12) and (4.467, 3.594—7.447), respectively. The Ktrans, Vp and AUC values of normal pancreas were (0.762, 0.389—0.918) ml/min, (0.222, 0.111—0.347), (6.597, 4.646—9.226), respectively. The Ktrans, Vp and AUC values of AP were lower than those of control group (all P<0.05). The Vp value of normal pancreas was no statistically significant difference among the head, body and tail (all P>0.05). The Ktrans and AUC values of normal pancreas were statistically significant difference between the head and body (all P<0.05), as well as between the head and tail (all P< 0.05). But no statistical difference was found between the body and tail (all P>0.05).Conclusions: DCE-MRI can quantify the microcirculation perfusion of the pancreas with noninvasive and no radiation, and lay the foundations of theory and practice for further study the AP perfusion.
[Keywords] Pancreas；Pancreatitis；Magnetic resonance imaging

HU Ran Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China

CHEN Yong Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China

XIE Chao-lian Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China

TANG Meng-yue Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China

ZENG Nan-lin Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China

CHEN Tian-wu Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China

ZHANG Xiao-ming* Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China

LI Xin GE Healthcare China, Shanghai 200000, China

*Correspondence to: Zhang XM, Email:cjr.zhxm@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This research is funded by the project of the youth scientific and technological innovation research team of Sichuan Province No. 2011JTD0030
Received  2017-08-29
Accepted  2017-11-28
DOI: 10.12015/issn.1674-8034.2018.03.007
DOI:10.12015/issn.1674-8034.2018.03.007.

[1]
Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med, 2017, 376(6): 598-599.
[2]
Kovalska I, Dronov O, Zemskov S, et al. Patterns of pathomorphological changes in acute necrotizing pancreatitis. Int J Inflam, 2012, 2012:508915.
[3]
Sourbron SP, Buckley DL. Classic models for dynamic contrast-enhanced MRI. NMR Biomed, 2013, 26(8): 1004-1027.
[4]
Zhao WW, Ren J, Yin H, et al. Feasibility of quantitative assessment of pancreatic perfusion with dynamic contrast-enhanced MRI in healthy volunteers. Chin J Med Imaging Technol, 2017, 33(6): 893-896.赵娓娓，任静，印弘，等．动态增强磁共振成像定量评估健康志愿者胰腺灌注的可行性．中国医学影像技术, 2017, 33(6): 893-896.
[5]
Yao X, Zeng M, Wang H, et al. Evaluation of pancreatic cancer by multiple breath-hold dynamic contrast-enhanced magnetic resonance imaging at 3.0 T. Eur J Radiol, 2012, 81(8): e917-e922.
[6]
Kim H, Arnoletti PJ, Christein J, et al. Pancreatic adenocarcinoma: a pilot study of quantitative perfusion and diffusion-weighted breath-hold magnetic resonance imaging. Abdom Imaging, 2014, 39(4): 744-752.
[7]
Kim JH, Lee JM, Park JH, et al. Solid pancreatic lesions: characterization by using timing bolus dynamic contrast-enhanced MR imaging assessment: a preliminary study. Radiology, 2013, 266(1): 185-196.
[8]
Huh J, Choi Y, Woo DC, et al. Feasibility of test-bolus DCE-MRI using CAIPIRINHA-VIBE for the evaluation of pancreatic malignancies. Eur Radiol, 2016, 26(11): 3949-3956.
[9]
Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
[10]
Khalifa F, Soliman A, El-Baz A, et al. Models and methods for analyzing DCE-MRI: a review. Med Phys, 2014, 41(12): 124301.
[11]
Klar E, Werner J. New pathophysiologic knowledge about acute pancreatitis. Chirurg, 2000, 71(3): 253-264.
[12]
Karne S, Gorelick FS. Etiopathogenesis of acute pancreatitis. Surg Clin North Am, 1999, 79(4): 699-710.
[13]
Tian C, Xu X. Multislice spiral perfusion computed tomography to assess pancreatic vascularity in mild acute pancreatitis. J Comput Assist Tomogr, 2017, 41(2): 284-288.

PREV Histogram texture analysis on vulnerability of symptomatic plaques in intracranial atherosclerosis
NEXT Dynamic contrast enhanced MRI for pancreatic perfusion in acute pancreatitis
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn