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• Clinical Article •
The application value of diffusion kurtosis imaging and histogram analysis for assessing preoperative T stages of rectal cancer
XIE Hui  WU Guang-yao 

DOI:10.12015/issn.1674-8034.2018.03.009.


[Abstract] Objective: To explore the value of diffusion kurtosis imaging (DKI) and histogram analyses for assessing preoperative T stages of rectal cancer.Materials and Methods: Fifty patients were enrolled confirmed rectal adenocarcinoma by pathology from our hospital. The value of DKI parameters and histogram metrics for assessing preoperative T stages in rectal cancer were retrospectively analyzed.Results: (1) In all, there were 19 early rectal cancer (T1-2) and 31 advanced cancer (T3-4). ADC- 10th and ADC-25th were significantly higher in T1-2 than in T3-4 rectal cancer [the ADC value were (0.65±0.08)×10-3 mm2/s vs (0.58±0.11)×10-3 mm2/s, (0.73±0.11)×10-3 mm2/s vs (0.65±0.11)×10-3 mm2/s, and the P value were 0.035, 0.024 respectively]. (2) D-10th and D-25th were also significantly higher in T1-2 than in T3-4 rectal cancer [the D value were 0.96±0.19 × 10-3 mm2/s vs 0.84±0.16×10-3 mm2/s, 1.15±0.27×10-3 mm2/s vs 0.99±0.18×10-3 mm2/s, and the P value were 0.017, 0.044 respectively]. (3) K value and its histogram metrics showed no statistically significance between T1-2 and T3- 4. (4) D-10th had the biggest area under the curve (AUC 0.799) of all the parameters, the sensitivity and specificity were 84.2%, 61.3% respectively. (5) DKI combined with traditional MRI had an accuracy of 68% to assess the lymph node of rectal cancer.Conclusions: DKI and its histogram metrics are quite valuable for assessing preoperative T stages of rectal cancer, and D-10th has the highest diagnostic efficiency.
[Keywords] Rectal neoplasms；Neoplasm staging；Magnetic resonance imaging

XIE Hui Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R.China

WU Guang-yao* Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R.China

*Correspondence to: Wu GY, E-mail: wuguangy2002@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was funded by Major Program of the National Natural Science Foundation of China No. 81227902 the National Key Basic Research Program National Natural Science Foundation of China No. 2016YFC1304702
Received  2017-10-11
Accepted  2017-11-29
DOI: 10.12015/issn.1674-8034.2018.03.009
DOI:10.12015/issn.1674-8034.2018.03.009.

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