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• Clinical Article •
Value of quantitative dynamic contrast-enhanced MRI in the evaluation of bone marrow perfusion in the adult hip
DAI Bei  ZOU Yue-fen 

DOI:10.12015/issn.1674-8034.2018.03.011.


[Abstract] Objective: To evaluate the bone marrow perfusion in the adult hip at quantitative dynamic contrast-enhanced MRI (DCE-MRI) with regard to sex, age and skeletal site.Materials and Methods: This retrospective study includes 168 patients who underwent DCE-MRI. Quantitative parameters Ktrans, Kep, Ve were calculated in the acetabulum, femoral epiphysis and metaphysis. The parameters at different regions were compared by Kruskal-Wallis test. The correlations between age and quantitative parameters in different sites were calculated using Spearman rank coefficient analysis in men and women respectively. Patients were then stratified into two groups, those 50 years or younger and those older than 50 years old. Perfusion parameters in different locations between different genders were compared by using the Wilcoxon signed-rank tests in each age group.Results: This study includes 168 patients (88 men, mean age, 59.97 years [age range, 22—89 years], 80 women, mean age 57.69 years [age range, 21—85 years]). A significant difference (P<0.05) in Ktrans, Kep, Ve was found among different skeletal sites. There was a significant correlation between age and Ktrans, Kep, Ve of the acetabulum (Spearman rs=-0.532,-0.476,-0.319 in men and-0.566,-0.387,-0.406 in women respectively), between age and Ve of femoral epiphysis in men (rs=-0.152), between age and Kep of femoral epiphysis in women (rs=0.282), between age and Ktrans, Kep of femoral metaphysis in women (rs = -0.200,-0.297), P<0.05. The Ktrans, Kep, Ve of the acetabulum and femoral metaphysis were significantly different between males and females in patients younger than 50 (P<0.05). Males and females revealed no difference for Ve of the acetabula and femoral epiphysis in patients older than 50 years old (P>0.05), while other parameters were statistically different (P<0.05).Conclusions: DCE-MRI is a technique that acquires perfusion parameters in the hip non-invasively quantitatively. Bone marrow perfusion parameters in the adult hip are influenced by location, gender and age.
[Keywords] Bone marrow；Perfusion；Magnetic resonance imaging；Hip joint

DAI Bei Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

ZOU Yue-fen* Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

*Correspondence to: ZOU YF, E-mail: zou_yf@163.com

Conflicts of interest   None.

Received  2017-11-06
Accepted  2017-12-10
DOI: 10.12015/issn.1674-8034.2018.03.011
DOI:10.12015/issn.1674-8034.2018.03.011.

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