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• Clinical Article •
Study on the correlation between the phase of the magnetic sensitivity of the deep nucleus of the brain and the MMSE in AD patients
DONG Chen-yu  WANG Xiao-ming 

DOI:10.12015/issn.1674-8034.2018.04.001.


[Abstract] Objective: To evaluate the iron deposition in deep brain nucleus of Alzheimer’s disease (AD) patients and determine its correlation with MMSE score using susceptibility-weighted imaging (SWI).Materials and Methods: From November 2015 to December 2016, 21 cognitively normal subjects (4 male, 13 female, age 47 to 82) and 17 patients (9 male, 12 female, age 48 to 78) with Alzheimer’s disease were scaned with both routine MRI sequences and SWI sequences using Philip Ingenia 3.0 T MRI. Software is used to generate SWI pictures. The phase value of caudate nucleus, substantia nigra, red nucleus, globus pallidus and putamen were measured in the corrected phase images. Then calculate the correlations between phase value and mini-mental state examination (MMSE) score. Statistical analysis is done by SPSS and MedCalc software package. First compare the phase value of caudate nucleus, substantia nigra, red nucleus, globus pallidus, and putamen between Alzheimer’s patients and control group. Then calculate the correlations between phase value and MMSE score (P<0.01).Results: In SWI sequences, the phase value of right substantia nigra and bilateral caudate nucleus between AD patients and healthy people are significantly different (Pleft caudate nucleus<0.001, Pright caudate nucleus=0.002, Pright substantia nigra=0.012). Correlation between iron deposition in right substantia nigra and bilateral caudate nucleus and MMSE score in AD patients were found.Conclusions: SWI technology can reflect the iron deposition in deep brain gray nucleus in AD patients respectively and non-invasively, thus helping the early diagnosis of AD.
[Keywords] Alzheimer disease；Susceptibility-weighted imaging；Iron deposition；Magnetic resonance imaging

DONG Chen-yu Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

WANG Xiao-ming* Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

*Corresponding to: Wang XM, E-mail: wangxm024@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81471720 Basic Research Project of Key Laboratory of Educating Department of Liaoning Province No.LZ2014039 Outstanding Scientific Fund of Shengjing Hospital No.201402
Received  2017-12-29
Accepted  2018-02-23
DOI: 10.12015/issn.1674-8034.2018.04.001
DOI:10.12015/issn.1674-8034.2018.04.001.

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