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• Clinical Article •
The application value of 1H-MRS in the treatment of hyperacute cerebral infarction by using short-TE scanning
SHANG Wen-wen  XUE Lian  ZHANG Hui-li  XUE Hai-lin  SUN Jun 

DOI:10.12015/issn.1674-8034.2018.04.002.


[Abstract] Objective: To investigate the application value of magnetic resonance spectroscopy (MRS) in the treatment of hyperacute cerebral infarction by using stimulated echo acquisition mode and short echo time scan.Materials and Methods: The patients of hyperacute infarction treated with thrombolytic therapy or non-thrombolytic therapy underwent regular magnetic resonance and MR spectrum scan after 1 week of hospitalization. Then we respectively analyzed the ratios of NAA/Cr, Cho/Cr and NAA/Cho in the infraction center, the border region, the normal region around the lesion and the contralateral area.Results: (1) In the non-thrombolysis group, in the infraction center,the ratios of NAA/Cr, NAA/Cho decreased significantly, the ratios of Cho/Cr and mI/Cr were higher than in the border region, the ratio of Glx/Cr was higher than that in the contralateral area (P<0.05). In the border region, the ratio of AA/Cr was lower than in the normal region around the lesion, and the ratio of NAA/Cho was lower than in the contralateral area (P<0.05). The ratios of NAA/Cho, Cho/Cr and Glx/Cr in the infraction center and Lac/Cr in the border region were significantly correlated with the clinical NIHSS score (r=-0.626, 0.629, -0.689, 0.812, P<0.05). (2)In the thrombolysis group, in the infraction center, the ratio of Cho/Cr was higher than in the border region. In the border region, the ratios of NAA/Cr, mI/Cr were lower than in the contralateral area, and the ratio of NAA/Cho was lower than in the normal region around the lesion. The ratios of NAA/Cho, Cho/Cr, mI/Cr and Glx/Cr in the infraction center and Lac/Cr in the border region were significantly correlated with the clinical NIHSS score (r=-0.686, 0.791, -0.757, -0.791, 0.735, P<0.05). (3) In the thrombolysis group, the ratios of NAA/Cr, NAA/Cho and mI/Cr in the infraction center, the border region was significantly higher than in non-thrombolysis group, the ratio of Lac/Cr in the infraction center, the border region and the normal region around the lesion was lower than that in non-thrombolysis group, the ratio of Glx/Cr in the infraction center was significantly higher than in non-thrombolysis group.Conclusions: 1H-MRS can detect more metabolite changes by using short echo time scanning and more comprehensively detect the recovery of damaged brain tissue after the clinical treatment. It can objectively evaluate the effect of clinical treatment and prognosis of cerebral infarction, providing objective imaging evidence for clinical application.
[Keywords] Proton magnetic resonance spectroscopy；Stimulated echo acquisition mode；Short echo time；Stroke；Magnetic resonance imaging

SHANG Wen-wen School of Radiology, Jiangsu Vocational College of Medicine, Yancheng 224000, China

XUE Lian Department of Radiology, Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou 511495, China

ZHANG Hui-li School of Radiology, Jiangsu Vocational College of Medicine, Yancheng 224000, China

XUE Hai-lin Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

SUN Jun* Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

*Corresponding to: Sun J, E-mail: 13505194324@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Medical Science and Technology Development Project of Yancheng in 2016 No. YK2016052 Medical Science and Technology Development Project of Yancheng in 2017 No. YK2017057
Received  2017-12-28
Accepted  2018-02-02
DOI: 10.12015/issn.1674-8034.2018.04.002
DOI:10.12015/issn.1674-8034.2018.04.002.

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