Share：
Share this content in WeChat
X
[Chinese][PDF]73872
• Clinical Article •
The value of diagnosis of suspicious malignant breast lesions by magnetic resonance diffusion combined with perfusion imaging technique
ZHANG Hui  WANG Yong 

DOI:10.12015/issn.1674-8034.2018.04.005.


[Abstract] Objective: To evaluate the value of diffusion-weighted imaging (DWI) and perfusion imaging in diagnosing breast lesions of the BI-RADS 4 diagnosed by mammography and compared them with histopathology.Materials and Methods: From May 2014 to May 2017, there were 95 breast lesions in 83 patients which were examed in Hebei General Hospital. Two high-seniority physicians retrospectively analyzed the MRI features of breast lesions and measured the apparent diffusion coefficient (ADC) and perfusion imaging quantitative parameters of all lesions. The variance analysis of the difference between benign and malignant lesions of ADC values was carried out.Results: These 95 lesions were divided into two groups according to histopathological diagnosis. There were 46 lesions in the benign lesion group, 49 lesions in the malignant lesion group. In these 2 groups, the average ADC value of the malignant lesion group was significantly lower than the other group (P<0.05), and the average ADC value was significantly different (P<0.05). The averages of Ktrans and Kep showed statistically significant differences in the perfusion quantitative parameters of benign and malignant lesions (P<0.05).Conclusions: DWI technology and perfusion imaging technique can distinguish benign and malignancy effectively.
[Keywords] Magnetic resonance imaging；Breast diseases；Diffusion weighted imaging；Perfusion weighted imaging；Histopathology

ZHANG Hui* Department of Radiology, Hebei General Hospital, Shijiazhuang 050000, China

WANG Yong Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

*Corresponding to: Zhang H, E-mail: wszzzhui@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Key Project of Medical Science in Hebei Province No.20110229
Received  2017-11-21
Accepted  2018-03-13
DOI: 10.12015/issn.1674-8034.2018.04.005
DOI:10.12015/issn.1674-8034.2018.04.005.

[1]
El Khouli RH, Jacobs MA, Mezban SD, et al. Diffusion-weighted imaging improves the diagnostic accuracy of conventional 3.0 T breast MR imaging. Radiology, 2010, 256(1): 64-73.
[2]
Jiang L, Lu X, Hua B, et al. Intravoxel incoherent motion diffusion-weighted imaging versus dynamic contrast-enhanced magnetic resonance imaging: comparison of the diagnostic performance of perfusion-related parameters in breast. J Comput Assist Tomogr, 2018, 42(1): 6-11.
[3]
Jia ZZ, Shi W, Shi JL, et al. Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in assessing glioblastoma microvasculature. Eur J Radiol, 2017, 87(12): 120-124.
[4]
Zervoudis S, Iatrakis G, Tomara E, et al. Main controversies in breast cancer. World J Clin Oncol, 2014, 5(3): 359-373.
[5]
American College of Radiology. ACR BI-RADS®, Breast imaging reporting and data system. Reston, VA: American College of Radiology, 2013.
[6]
Hartmann LC, Sellers TA, Frost MH, et al. Benign breast disease and the risk of breast cancer. N Engl J Med, 2005, 353(3): 229-237.
[7]
Maltez de Almeida JR, Gomes AB, Barros TP, et al. Subcategorization of suspicious breast lesions (BI-RADS category 4) according to MRI criteria: role of dynamic contrast-enhanced and diffusion-weighted imaging. AJR Am J Roentgenol, 2015, 205(1): 222-231.
[8]
Thomassin-Naggara I, De Bazelaire C, Chopier J, et al. Diffusion-weighted MR imaging of the breast: advantages and pitfalls. Eur J Radiol, 2013, 82(3): 435-443.
[9]
Pereira FPA, Martins G, Carvalhaes de Oliveira RV. Diffusion magnetic resonance imaging of the breast. Magn Reson Imaging Clin N Am, 2011, 19(1): 95-110.
[10]
Pereira FPA, Martins G, Figueiredo E, et al. Assessment of breast lesions with diffusion-weighted MRI: comparing the use of different b values. AJR Am J Roentgenol, 2009, 193(4): 1030-1035.
[11]
Brandão AC, Lehman CD, Partridge SC. Breast magnetic resonance imaging: diffusion-weighted imaging. Magn Reson Imaging Clin N Am, 2013, 21(2): 321-336.
[12]
Tsushima Y, Takahashi-Taketomi A, Endo K. Magnetic resonance (MR) differential diagnosis of breast tumors using apparent diffusion coefficient (ADC) on 1.5 T. J Magn Reson Imaging, 2009, 30(2): 249-255.
[13]
Parsian S, Rahbar H, Allison KH, et al. Nonmalignant breast lesions: ADCs of benign and high-risk subtypes assessed as false-positive at dynamic enhanced MR imaging. Radiology, 2012, 265(3): 696-706.
[14]
Spick C, Pinker-Domenig K, Rudas M, et al. MRI-only lesions: application of diffusion-weighted imaging obviates unnecessary MR guided breast biopsies. Eur Radiol, 2014, 24(6): 1204-1210.
[15]
Ryu JK, Rhee SJ, Song JY, et al. Characteristics of quantitative perfusion parameters on dynamic contrast-enhanced MRI in mammographically occult breast cancer. J Appl Clin Med Phys, 2016, 17(5): 6091
[16]
Han M, Kim TH, Kang DK, et al. Prognostic role of MRI enhancement features in patients with breast cancer: value of adjacent vessel sign and increased ipsilateral whole-breast vascularity. AJR Am J Roentgenol, 2012, 199(4): 921-928.

PREV Texture analysis of conventional MRI parameters for differentiating between hemangioma meningioma and hemangiopericytoma based on whole tumor measurement
NEXT Evaluating hepatic function of hepatic alveolar echinococcosis with magnetic resonance diffusion weighted imaging: initial study
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn