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• Review •
Research and progress of magnetic resonance imaging on coronary microembolization using animal models
ZHAO Shi-hai  JIN Hang 

DOI:10.12015/issn.1674-8034.2018.04.013.


[Abstract] Coronary microembolization (CME) occurs frequently in acute coronary syndrome and the process of percutaneous coronary intervention (PCI), which is very harmful for patients. In recent years, the number of patients receiving PCI in China has increased significantly, and the coronary microembolization after PCI also becomes more common than ever. Compared with other methods, magnetic resonance imaging (MRI) is a noninvasive method without ionizing radiation and has the advantages of high soft tissue resolution and "one-stop" inspection with cardiac anatomy and function information. MRI plays an important role in the study on coronary microembolization and can be used to assess myocardial function, perfusion abnormalities and myocardial activity related to coronary microembolization. Animal models of coronary microembolization were commonly used in-depth study on pathophysiology of CME and mechanism of relevant myocardial injury. This review focused on research and progress in MRI on coronary microembolization of animal models.
[Keywords] Coronary microembolization；Magnetic resonance imaging；Animal models

ZHAO Shi-hai Department of Radiology, Zhongshan Hospital, Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032, China; Department of Medical Imaging, Shanghai Medical College of Fudan University, Shanghai 200032, China

JIN Hang* Department of Radiology, Zhongshan Hospital, Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032, China; Department of Medical Imaging, Shanghai Medical College of Fudan University, Shanghai 200032, China

*Corresponding to: Jin H, E-mail:hangjin08@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81201070
Received  2017-11-20
Accepted  2018-01-24
DOI: 10.12015/issn.1674-8034.2018.04.013
DOI:10.12015/issn.1674-8034.2018.04.013.

[1]
Frohlich GM, Meier P, White SK, et al. Myocardial reperfusion injury: looking beyond primary PCI. Eur Heart J, 2013, 34(23): 1714-1722.
[2]
Dorge H, Neumann T, Behrends M, et al. Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation. Am J Physiol Heart Circ Physiol, 2000, 279(6): 2587-2592.
[3]
Gupta S, Gupta MM. No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction. Indian Heart J, 2016, 68(4): 539-551.
[4]
Jin H, Yun H, Ma J, et al. Coronary microembolization with normal epicardial coronary arteries and no visible infarcts on nitrobluetetrazolium chloride-stained specimens: evaluation with cardiac magnetic resonance imaging in a swine model. Korean J Radiol, 2016, 17(1): 83-92.
[5]
Symons R, Pontone G, Schwitter J, et al. Long-term incremental prognostic value of cardiovascular magnetic resonance after ST-segment elevation myocardial infarction: A study of the collaborative registry on CMR in STEMI. JACC Cardiovasc Imaging, 2017 DOI: . DOI: 10.1016/j.jcmg.2017.05.023.
[6]
陆永光，李浪.急性冠状动脉微栓塞动物模型的研究进展.心血管病学进展, 2010, 31(3): 452-454.
[7]
Pontone G, Carita P, Rabbat MG, et al. Role of cardiac magnetic resonance imaging in myocardial infarction. Curr Cardiol Rep, 2017, 19(10): 101.
[8]
Stenberg TA, Steigen T, Myrmel T. Microvascular occlusions and coronary microembolization. Scand Cardiovasc J, 2011, 45(5): 258-260.
[9]
Breuckmann F, Nassenstein K, Bucher C, et al. Systematic analysis of functional and structural changes after coronary microembolization: a cardiac magnetic resonance imaging study. JACC Cardiovasc Imaging, 2009, 2(2): 121-130.
[10]
Carlsson M, Wilson M, Martin AJ, et al. Myocardial microinfarction after coronary microembolization in swine: MR imaging characterization. Radiology, 2009, 250(3): 703-713.
[11]
Carlsson M, Jablonowski R, Martin AJ, et al. Coronary microembolization causes long-term detrimental effects on regional left ventricular function. Scand Cardiovasc J, 2011, 45(4): 205-214.
[12]
Saeed M, Van TA, Krug R, et al. Cardiac MR imaging: current status and future direction. Cardiovasc Diagn Ther, 2015, 5(4): 290-310.
[13]
Nassenstein K, Breuckmann F, Bucher C, et al. How much myocardial damage is necessary to enable detection of focal late gadolinium enhancement at cardiac MR imaging?. Radiology, 2008, 249(3): 829-835.
[14]
Falk E. Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation, 1985, 71(4): 699-708.
[15]
Carrick D, Haig C, Ahmed N, et al. Myocardial hemorrhage after acute reperfused ST-segment-elevation myocardial infarction: relation to microvascular obstruction and prognostic significance. Circ Cardiovasc Imaging, 2016, 9(1): e4148.
[16]
Kali A, Tang RL, Kumar A, et al. Detection of acute reperfusion myocardial hemorrhage with cardiac MR imaging: T2 versus T2. Radiology, 2013, 269(2): 387-395.
[17]
Ghugre NR, Ramanan V, Pop M, et al. Quantitative tracking of edema, hemorrhage, and microvascular obstruction in subacute myocardial infarction in a porcine model by MRI. Magn Reson Med, 2011, 66(4): 1129-1141.
[18]
Abdel-Aty H, Cocker M, Meek C, et al. Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study. J Am Coll Cardiol, 2009, 53(14): 1194-1201.
[19]
Kellman P, Aletras AH, Mancini C, et al. T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo. Magn Reson Med, 2007, 57(5): 891-897.
[20]
Nordlund D, Heiberg E, Carlsson M, et al. Extent of myocardium at risk for left anterior descending artery, right coronary artery, and left circumflex artery occlusion depicted by contrast-enhanced steady state free precession and T2-weighted short tau inversion recovery magnetic resonance imaging. Circ Cardiovasc Imaging, 2016, 9(7): e4376.
[21]
Fernández-Jiménez R, Garcia-Prieto J, Sanchez-Gonzalez J, et al. Pathophysiology underlying the bimodal edema phenomenon after myocardial ischemia/reperfusion. J Am Coll Cardiol, 2015, 66(7): 816-828.
[22]
Skyschally A, Haude M, Dorge H, et al. Glucocorticoid treatment prevents progressive myocardial dysfunction resulting from experimental coronary microembolization. Circulation, 2004, 109(19): 2337-2342.
[23]
Jin H, Yun H, Ma JY, et al. Assessment of the acute effects of glucocorticoid treatment on coronary microembolization using cine, first-pass perfusion, and delayed enhancement MRI. J Magn Reson Imaging, 2016, 43(4): 921-928.
[24]
Chen Z, Qian J, Ma J, et al. Glucocorticoid ameliorates early cardiac dysfunction after coronary microembolization and suppresses TGF-beta1/Smad3 and CTGF expression. Int J Cardiol, 2013, 167(5): 2278-2284.
[25]
Chen ZW, Qian JY, Ma JY, et al. TNF-alpha-induced cardiomyocyte apoptosis contributes to cardiac dysfunction after coronary microembolization in mini-pigs. J Cell Mol Med, 2014, 18(10): 1953-1963.

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