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• Clinical Article •
A preliminary study on the effects of secondary perfusion on the hemodynamics of the total quantitative brain perfusion
XIE Huan  ZHANG Yu-long 

DOI:10.12015/issn.1674-8034.2018.05.001.


[Abstract] Objective: To investigate the effects of secondary perfusion on the hemodynamics of the total quantitative brain perfusion and obtain the optimal injection timing.Materials and Methods: The 100 volunteers who had no cerebrovascular disease were divided into five groups according to the timing of injection (3, 5, 7, 9 and 11), while taking MR conventional scanning and complete quantitative perfusion scanning. The cerebral bleeding flow (CBF) and cerebral blood volume (CBV) were calculated automatically. The time-signal strength diagram was described by the conventional perfusion weighted imaging (PWI) post-processing methods. Then we can analyze whether there was a second perfusion. The values of CBF and CBV of the subjects' interest areas (frontal lobes, thalamus and cerebellum) were measured.Results: The probability of secondary perfusion was 95% and 80% respectively in the patients with total quantitative perfusion in the 3rd and 5th injection. The probability of secondary perfusion in phase 7 and 9 was 10% and 5% respectively. The probability of the second perfusion was 0% in the 11th injection, but the timing was too late and the data was meaningless. Secondly, there was no statistically significant difference between the bilateral frontal lobes, thalamus and cerebellum in different injection period (P>00.05). The CBV and CBF values of the frontal lobes, thalamus and cerebellum in different injection periods were measured, and the CBV and CBF values of the obvious secondary perfusion were compared with the CBV and CBF values that did not exist in the second perfusion, and the CBV and CBF values of the secondary perfusion were significantly larger.Conclusions: The best injection period of total quantitative perfusion was in period 7—9. The CBV and CBF values of the secondary perfusion were significantly higher.
[Keywords] Brain；Perfusion imaging；Hemodynamics；Magnetic resonance imaging

XIE Huan Department of Radiology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China

ZHANG Yu-long* Department of Radiology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China

*Correspondence to: Zhang YL, E-mail: Yulong_z@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Chongqing Clinical Research Centre of Imaging and Nuclear Medicine No. CSTC2015YFPTgcjsyjzx0175 Central Government Guide the Development of Local Science and Technology Special Fund No. YDZX20175000004270
Received  2017-12-19
Accepted  2018-03-05
DOI: 10.12015/issn.1674-8034.2018.05.001
DOI:10.12015/issn.1674-8034.2018.05.001.

[1]
张孝琴，李建策，王娜娜,等.注射流率对脑磁共振灌注成像血流动力学的影响.中国生物医学工程学报, 2015, 34(2): 253-256.
[2]
Ran YC, Zhu M, Zhang Y, et al. Perfusion weighted magnetic resonance imaging in the assessment of haemodynamicsfollowing stent angioplasty in patients with symptomatic middle cerebral arteryplaque stenosis at the M1 segment. Exp Ther Med, 2017, 14(3): 1899-1904.
[3]
罗祖明，丁新生.缺血性脑血管病学.北京:人民卫生出版社, 2011: 30-37.
[4]
Mankoff DA, Dunnwald LK, Partridge SC, et al. Blood flow-metabolism mismatch: good for tumor, bad for the patient. Clin Cancer Res, 2009, 15(17): 5294-5296.
[5]
Tong E, Sugrue L, Wintermark M. Understanding the neurophysiology and quantification of brain perfusion. Top Magn Reson Imaging, 2017, 26(2): 57-65.
[6]
Grandin CB, Bol A, Smith AM, et al. Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: repeatabilily and comparison with PET in humans. NeuroImage, 2005, 26(2): 525-535.
[7]
贾文霄，陈敏.磁共振功能成像临床应用.北京:人民军医出版社, 2012: 74-77.
[8]
Mendichovszky IA, Cutajar M, Gordon I. Reproducibility of the aortic input function (AIF) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the kidneys in a volunteer study. Eur J Radiol, 2009, 71(3): 576-581.
[9]
Srour JM, Shin W, Shah S, et al. SCALE-PWIS: a pulse sequence for absolute quantitative cerebral perfusion imaging. J Cereb Blood Flow Metab, 2010, 31: 1272-1282.
[10]
Naganawa S, Sato K, Katagin T, et al. Regional ADC values of the normal brain: differences due to age, gender,and laterality. Eur Radiol, 2003, 13(1): 6-11.
[11]
Zappe AC, Reichold J, Burger C, et al. Quantification of cerebral blood flow in nonhuman primates using arterial spin labeling and two-compartment model. Magn Reson Imaging, 2007, 25(6): 775-783.
[12]
Liu HL, Kochunov P, Hou J, et al. Perfusion-weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIRHASTE: comparison with H(2)(15)O PET measurements. Magn Res Med, 2001, 45(3): 431-435.
[13]
Bos A, Bergmann R, Strobel K, et al. Cerebral blood flow quantification in the rat: a direct comparison of arterial spin labeling MRI with radioactive microsphere PET. ENMMI Res, 2012, 2(1): 47-54.
[14]
刘娜，李道伟，马强,等. 3D ASL评价急性脑梗死溶栓前后脑血流动力学的价值.磁共振成像, 2017, 8(11): 807-811.
[15]
徐浩，赵周社. PET脑血流量测量方法和临床应用进展.现代生物医学进展, 2015, 15(2): 355-358.
[16]
王善诚，李澄，瞿航,等.磁共振灌注加权成像在糖尿病脑损害中的应用进展.磁共振成像, 2017, 8(2): 155-160.
[17]
Wong KK, Fung SH, New PZ, et al. Technical Pitfalls of Signal Truncation in Perfusion MRI of Glioblastoma. Front Neurol, 2016, 7: 121.
[18]
Zhang SX, Yao YH, Zhang S, et al. Comparative study of DSC-PWI and 3D-ASL in ischemic stroke patients. J Huazhong Univ Sci Technolog Med Sci, 2015, 35(6): 923-927.
[19]
Simonsen CZ, Madsen MH, Schmitz ML, et al. Sensitivity of diffusion- and perfusion-weighted imaging for diagnosing acute ischemic stroke is 97.5%. Storke, 2015, 46(1): 98-101.

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