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• Clinical Article •
A preliminary study on the effects of secondary perfusion on the hemodynamics of the total quantitative brain perfusion
XIE Huan  ZHANG Yu-long 

DOI:10.12015/issn.1674-8034.2018.05.001.


[Abstract] Objective: To investigate the effects of secondary perfusion on the hemodynamics of the total quantitative brain perfusion and obtain the optimal injection timing.Materials and Methods: The 100 volunteers who had no cerebrovascular disease were divided into five groups according to the timing of injection (3, 5, 7, 9 and 11), while taking MR conventional scanning and complete quantitative perfusion scanning. The cerebral bleeding flow (CBF) and cerebral blood volume (CBV) were calculated automatically. The time-signal strength diagram was described by the conventional perfusion weighted imaging (PWI) post-processing methods. Then we can analyze whether there was a second perfusion. The values of CBF and CBV of the subjects' interest areas (frontal lobes, thalamus and cerebellum) were measured.Results: The probability of secondary perfusion was 95% and 80% respectively in the patients with total quantitative perfusion in the 3rd and 5th injection. The probability of secondary perfusion in phase 7 and 9 was 10% and 5% respectively. The probability of the second perfusion was 0% in the 11th injection, but the timing was too late and the data was meaningless. Secondly, there was no statistically significant difference between the bilateral frontal lobes, thalamus and cerebellum in different injection period (P>00.05). The CBV and CBF values of the frontal lobes, thalamus and cerebellum in different injection periods were measured, and the CBV and CBF values of the obvious secondary perfusion were compared with the CBV and CBF values that did not exist in the second perfusion, and the CBV and CBF values of the secondary perfusion were significantly larger.Conclusions: The best injection period of total quantitative perfusion was in period 7—9. The CBV and CBF values of the secondary perfusion were significantly higher.
[Keywords] Brain；Perfusion imaging；Hemodynamics；Magnetic resonance imaging

XIE Huan Department of Radiology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China

ZHANG Yu-long* Department of Radiology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China

*Correspondence to: Zhang YL, E-mail: Yulong_z@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Chongqing Clinical Research Centre of Imaging and Nuclear Medicine No. CSTC2015YFPTgcjsyjzx0175 Central Government Guide the Development of Local Science and Technology Special Fund No. YDZX20175000004270
Received  2017-12-19
Accepted  2018-03-05
DOI: 10.12015/issn.1674-8034.2018.05.001
DOI:10.12015/issn.1674-8034.2018.05.001.

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