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• Clinical Article •
Research on changes in three core networks for amnestic mild cognitive impairment based on resting-state fMRI
FENG Qi  MAO De-wang  WANG Mei  LIAO Zheng-luan  YU En-yan  YUAN Jian-hua  DING Zhong-xiang 

DOI:10.12015/issn.1674-8034.2018.05.002.


[Abstract] Objective: The purpose of the present study was to identify neuroimaging biomarkers for amnestic mild cognitive impairment (aMCI).Materials and Methods: We implemented voxel-mirrored homotopic connectivity (VMHC) and Granger causality analysis (GCA) on the resting-state fMRI data of 30 patients with Alzheimer's disease (AD), 14 patients with aMCI, and 18 healthy controls (HC).Results: Using VMHC and GCA techniques, we revealed differences in connectivity of the three core networks that include the default-mode network (DMN), salience network (SN), and executive control network (ECN) among these three groups. The VMHC revealed significantly decreased connectivity in the AD group compared with the HC and aMCI groups within the triple networks, but there were no group differences between aMCI and HC subjects. The directed connectivity obtained from GCA could differentiate between the AD, aMCI and HC groups.Conclusions: These findings suggest that changes observed in triple networks can be used as a neuroimaging indicator for aMCI patients to distinguish between AD, aMCI patients and normal volunteers.
[Keywords] Magnetic resonance imaging；Alzheimer's disease；Cognitive dysfunction；Functional connectivity；Brain

FENG Qi Bengbu Medical College, Anhui Province, Bengbu 233030, China; Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China

MAO De-wang Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China

WANG Mei Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China

LIAO Zheng-luan Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China

YU En-yan Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China

YUAN Jian-hua Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China

DING Zhong-xiang* Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China

*Correspondence to: Ding ZX, E-mail: hangzhoudzx73@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Natural Science Foundation of Zhejiang Province No. Y2091289, LY16H180007, LY13H180016 Project of medical and health technology of Zhejiang Province No. 2013RCA001, 2016147373, ZKJ-ZJ-1503 Project supported by research innovation program of graduate students of Bengbu Medical College No. Byycx1738
Received  2017-12-20
Accepted  2018-01-26
DOI: 10.12015/issn.1674-8034.2018.05.002
DOI:10.12015/issn.1674-8034.2018.05.002.

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