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• Clinical Article •
The value of apparent diffusion coefficient in the differentiating diagnosis between primary central nervous system lymphoma and glioblastoma
LIN Yue  ZHANG Shuai  LI Chun-mei  CHEN Min 

DOI:10.12015/issn.1674-8034.2018.05.003.


[Abstract] Objective: To investigate the value of apparent diffusion coefficient in the differentiating diagnosis between primary central nervous system lymphoma and glioblastoma.Materials and Methods: This study retrospectively analyzed 17 cases of primary central nervous system lymphoma and 24 cases of glioblastoma (WHOⅣ grade) confirmed by surgery and pathology. The morphological features of MRI, the enhancement, the minimum-, mean-, and maximum apparent diffusion coefficient (ADC) (ADCmin, ADCmean, ADCmax) on the two diseases and the ratio of apparent diffusion coefficient value (rADC) of lesions and normal brain parenchyma were quantitatively analyzed.Results: The mean age at PCNSL and GBM did not differ significantly [(55.3±19.1) years and (58.2±15.1) years]. The MRI features of PCNSL compared with GBM include multiple lesions (70.6% vs 4.2%, P<0.001), significantly uniform enhancement (82.4% vs 4.2%, P<0.001) was apparently more common; whereas GBM showed more pronounced cystic degeneration, necrosis, and hemorrhage (100% vs 47.1%, P<0.001) compared with PCNSL. PCNSL have lower ADCmean value [(0.86 ± 0.34)× 103 mm2/s and (1.47 ± 0.57)×103 mm2/s, P=0.019) than those of GBM. The ratio ADC value of PCNSL were higher than those of GBM (1.16±0.63, 1.83 ± 0.38, P=0.020).Conclusions: This study confirms that the morphologic appearance, enhancement modalities, and their measured ADCmean values and their ratios are entirely valid for the identification of PCNSL and GBM.
[Keywords] Lymphoma；Glioma；Brain neoplasms；Magnetic resonance imaging

LIN Yue Beijing Hospital of Department of Radiology, National Center of Gerontology, Beijing 100730, China; Peking Union Medical College, Beijing 100005, China

ZHANG Shuai Beijing Hospital of Department of Radiology, National Center of Gerontology, Beijing 100730, China; Peking Union Medical College, Beijing 100005, China

LI Chun-mei Beijing Hospital of Department of Radiology, National Center of Gerontology, Beijing 100730, China

CHEN Min Beijing Hospital of Department of Radiology, National Center of Gerontology, Beijing 100730, China; Peking Union Medical College, Beijing 100005, China

*Correspondence to: Chen M, E-mail: chenmin62@yahoo.com

Conflicts of interest   None.

Received  2018-01-11
Accepted  2018-03-22
DOI: 10.12015/issn.1674-8034.2018.05.003
DOI:10.12015/issn.1674-8034.2018.05.003.

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