Share：
Share this content in WeChat
X
[Chinese][PDF]68084
• Clinical Article •
Investigation of correlation between IVIM and DCE-MRI on uterine cervical carcinoma
LIN Meng  ZHANG Qi  KONG Yue  YE Feng  YU Xiao-duo  OUYANG Han 

DOI:10.12015/issn.1674-8034.2018.05.006.


[Abstract] Objective: This study was aimed to analyze the correlation of perfusion parameters between the IVIM and DCE-MRI models to investigate the feasibility of perfusion evaluation by IVIM on uterine cervical carcinoma (UCC), and compare the difference of those perfusion parameters between squamous cell carcinoma (SCC) and adenocarcinoma (AdC).Materials and Methods: Fifty-three patients with newly diagnosed uterine cervical carcinoma were collected in our hospital from April 2016 to June 2017 and performed MRI examination before treatment, including intravoxel incoherent motion (IVIM) and dynamic contrasted-enhanced MRI (DCE-MRI) sequence. Perfusion parameters including D*, f, and fD* (f multiple by D*) derived from IVIM, Ktrans, Kep and Ve derived from DCE-MRI were calculated, and analyzed the correlation between those two models on UCC, SCC and AdC groups respectively using Spearman’s correlation. Independent sample t test and t’ test were conducted to compare the difference of those perfusion parameters between SCC and AdC, and ROC was used to compare the area under the curve (AUC), and analyze the cut-off of the most meaningful parameter and diagnostic efficiency.Results: D* and fD* were slightly and moderately positively correlated with all the three parameters of DCE-MRI on all UCC (r: 0.357—0.672), whereas f had no correlation with parameters of DCE-MRI. D* correlated positively with Ktrans highly on AdC (r=0.900) and moderately on SCC (r=0.669). AdC had higher f, Ktrans and Kep value than SCC (P: 0.002—0.013). With the cut-off of the f value less than 0.29 to diagnosis of AdC, the sensitivity, specificity and accuracy were 63.64%, 92.86% and 86.79%, respectively.Conclusions: Positive correlations were existed between perfusion parameters by IVIM and those of DCE-MRI on UCC, suggesting that IVIM could provide information about tumor perfusion. IVIM also was helpful to identify different pathological types of UCC.
[Keywords] Uterine cervical neoplasms；Magnetic resonance imaging

LIN Meng Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

ZHANG Qi Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

KONG Yue Department of Imaging, Beijing Shihua Acupotomology Hospital of traditional Chinese Medicine, Beijing 100021, China

YE Feng Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

YU Xiao-duo* Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

OUYANG Han Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

*Correspondence to: Yu Xiao-Duo, E-mail: yxd136@139.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the PUMC Youth Fund, Fundamental Research Funds for the Central Universities No. 3332016029
Received  2017-11-21
Accepted  2017-12-27
DOI: 10.12015/issn.1674-8034.2018.05.006
DOI:10.12015/issn.1674-8034.2018.05.006.

[1]
Chen W, Zheng R, Baade PD, et alCancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
[2]
Himoto Y, Fujimoto K, Kido A, et alAssessment of the early predictive power of quantitative magnetic resonance imaging parameters during neoadjuvant chemotherapy for uterine cervical cancer. Int J Gynecol Cancer, 2014, 24(4): 751-757.
[3]
Andersen EK, Hole KH, Lund KV, et alPharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome. Radiother Oncol, 2013, 107(1): 117-122.
[4]
周微，吕富荣.动态增强磁共振定量分析在常见子宫肿瘤中的应用.磁共振成像, 2017, 8(10): 796-800.
[5]
Le Bihan D. Intravoxel incoherent motion perfusion MR imaging: a wake-up call. Radiology, 2008, 249(3): 748-752.
[6]
胡莎莎，陈小莉，刘海峰,等.磁共振DWI、IVIM与宫颈癌病理学特征的相关性研究.磁共振成像, 2017, 8(10): 780-784.
[7]
FIGO Committee on Gynecologic Oncology. FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynaecol Obstet, 2014, 125(2): 97-98.
[8]
Dappa E, Elger T, Hasenburg A, et al. The value of advanced MRI techniques in the assessment of cervical cancer: a review. Insights Imaging, 2017, 8(5): 471-481.
[9]
Zhou N, Chu C, Dou X, et alEarly evaluation of irradiated parotid glands with intravoxel incoherent motion MR imaging: correlation with dynamic contrast-enhanced MR imaging. BMC Cancer, 2016, 16(1): 865.
[10]
Patel J, Sigmund EE, Rusinek H, et alDiagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience. J Magn Reson Imaging, 2010, 31(3): 589-600.
[11]
Zhou Y, Liu J, Liu C, et al. Intravoxel incoherent motion diffusion weighted MRI of cervical cancer: correlated with tumor differentiation and perfusion. Magn Reson Imaging, 2016, 34(8): 1050-1056.
[12]
Lee EY, Hui ES, Chan KK, et alRelationship between intravoxel incoherent motion diffusion-weighted MRI and dynamic contrast-enhanced MRI in tissue perfusion of cervical cancers. J Magn Reson Imaging, 2015, 42(2): 454-459.
[13]
Kaur H, Silverman PM, Iyer RB, et al. Diagnosis, staging, and surveillance of cervical carcinoma. AJR Am J Roentgenol, 2003, 180(6): 1621-1631.
[14]
Lin M, Yu X, Chen Y, et al. Contribution of mono-exponential, bi-exponential and stretched exponential model-based diffusion-weighted MR imaging in the diagnosis and differentiation of uterine cervical carcinoma. Eur Radiol, 2017, 27(6): 2400-2410.
[15]
张庆，徐香玖，周星,等. 3.0 T MR动态对比增强对宫颈癌组织学特性和临床分期的分析.临床放射学杂志, 2015, 34(10): 1607-1610.
[16]
郭吉敏，朱志军，张碧娟,等. 4D-THRIVE动态增强扫描评价早期宫颈癌微血管通透性的价值.临床放射学杂志, 2015, 34(4): 596-599.
[17]
朱志军，张碧娟，郭吉敏,等.动态增强MRI微血管通透性参数与Ⅱ期宫颈癌复发的相关性研究.放射学实践, 2015, 30(8): 841-844.

PREV Clinical evaluation of cardiac magnetic resonance tissue tracking technology for coronary heart disease patients with myocardial infarction
NEXT The effect of social evaluation threats on decision-making in social dilemmas: a rs-fMRI study
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn