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• Clinical Article •
Application study of local consistency with the resting state magnetic resonance imaging in first-episode patients with mild and moderate depression
SONG Xiao-lei  MAO Ning  ZHANG Qi  WANG Bin 

DOI:10.12015/issn.1674-8034.2018.06.001.


[Abstract] Objective: To explore the functional state of the abnormal brain regions in first-episode patients with mild and moderate depression using resting-state functional MRI (rs-fMRI) technology, which would provide a new idea for the exploration of the cause of depression and the clinical treatment.Materials and Methods: 14 first-episode patients with mild and moderate depression [live up to DSM-IV diagnostic criteria for depression, Hamilton Depression Scale (HAMD-17) score 17—24 points] and 14 matched healthy volunteers were examed by rs-fMRI. The KCC (Kendall's coefficient of concordance) of voxel is calculated based on the regional homogeneity (ReHo) method, and the ReHo value of each voxel of the whole brain is obtained. The statistical analysis is completed by SPM8 software package.Results: ReHo was significantly higher than the control group in the brain area of bilateral part of the brain of depression group, bilateral fusiform gyrus, bilateral cingulate gyrus, right cerebellum foot, right thalamus, right middle temporal gyrus, left medial dorsal nucleus of thalamus etc, while in the brain area of bilateral mesial frontal gyru, left middle frontal gyrus, left middle occipital gyrus, left inferior occipital gyrus, left paracentral lobule etc reduced significantly (P<0.05, K>10) on ReHo chart analysis of depression group and normal control group.Conclusions: Those changes in the BOLD signal in the local brain region of the patients with depression can indirectly reflect the changes in the time synchronism of the neurons in the functional brain region, which is helpful for the early and effective screening of the patients with depression and the location detection of the abnormal active brain area.
[Keywords] Depression；Magnetic resonance imaging, functional；Regional homogeneity

SONG Xiao-lei Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264003, China

MAO Ning Department of Radiology, Yantai Yuhuangding Hospital, Yantai 264000, China

ZHANG Qi Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264003, China

WANG Bin* Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264003, China

*Correspondence to: Wang B, E-mail: binwang001@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Foundation of Shandong Province No. ZR2016HL40, ZR2017PH043
Received  2018-01-11
Accepted  2018-04-24
DOI: 10.12015/issn.1674-8034.2018.06.001
DOI:10.12015/issn.1674-8034.2018.06.001.

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