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• Clinical Article •
Prognostic value of preoperative dynamic susceptibility contrast-enhanced MR imaging in patients with gliomas
LIANG Tian-tian  ZHANG Hui  WANG Xiao-chun  TAN Yan  QIN Jiang-bo  WANG Le  ZHANG Lei 

DOI:10.12015/issn.1674-8034.2018.06.002.


[Abstract] Objective: To investigate the relationship of maximum value of relative cerebral blood volume (rCBV) from dynamic susceptibility contrast-enhanced MRI (DSC-MRI) to prognosis in patients with gliomas.Materials and Methods: We conducted a retrospective analysis of the preoperative perfusion MR imaging in 62 histologically confirmed gliomas. Median relative CBV values were selected for quantitative analysis. Survival analysis was made by constructing survival curves using the Kaplan-Meier method with subgroups compared by Log-rank probability tests. A Cox regression model was made for multivariate analysis.Results: Kaplan-Meier survival curves demonstrated that overall survival of high rCBVmax (≥4.47) was significantly shorter than that of low rCBVmax (<4.47) (P<0.001), overall survival of low-grade glioma was significantly longer than that of high-grade glioma (P=0.001). Incooperating rCBVmax and pathological grade, the prognosis was best for the group of LGG+rCBVmax<4.47 and worst for the group of HGG+rCBVmax≥4.47. No significant difference was found between the group of LGG+rCBVmax≥4.47 and HGG+rCBVmax<4.47(P=0.154). Multivariate analysis suggested that rCBVmax was associated with survival independent of pathology (P=0.001).Conclusions: The rCBVmax value may be an independent indicator of prognosis in patients with glioma and an adjunct to WHO grading to determine clinical individual treatment.
[Keywords] Glioma；Perfusion weighted imaging；Magnetic resonance imaging；Dynamic susceptibility contrast

LIANG Tian-tian Department of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

ZHANG Hui* Department of Radiology, First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China

WANG Xiao-chun Department of Radiology, First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China

TAN Yan Department of Radiology, First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China

QIN Jiang-bo Department of Radiology, First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China

WANG Le Department of Radiology, First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China

ZHANG Lei Department of Radiology, First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China

*Correspondence to: Zhang H, E-mail: zhanghui_mr@163.com

Conflicts of interest   None.

Received  2018-01-24
Accepted  2018-03-08
DOI: 10.12015/issn.1674-8034.2018.06.002
DOI:10.12015/issn.1674-8034.2018.06.002.

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