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• Clinical Article •
Comparison of properties and module pattern of brain structural network between preterm and term neonates
JIN Chao  HU Ya-jie  LI Xian-jun  WANG Miao-miao  LI Yan-yan  CHENG Yan-nan  WANG Xiao-yu  TAO Xing-xing  ZHAO Hui-fang  YANG Jian 

DOI:10.12015/issn.1674-8034.2018.06.003.


[Abstract] Objective: To compare the properties and module pattern of brain structural network between preterm and term neonates.Materials and Methods: 20 preterm (gestational age, 30—37 weeks) and 22 term neonates (gestational age, 37—42 weeks) underwent 3D magnetic resonance T1-weighted imaging scan were recruited. All participants’ brain was segmented into 122 regions by using neonatal brain anatomical atlas and 64 gray matter regions were selected to reconstruct the binary brain volume network. The network properties and module pattern were compared between the two groups.Results: The brain structural network of two groups possessed the small-world properties; in contrast to term neonates, preterm showed statistically decreased clustering coefficient and local efficiency (P<0.05), and unorganized module pattern.Conclusions: The brain structural network of preterm and term neonates showed the small-world properties. The decreased information-transformation efficiency and unorganized module pattern may suggest the delay or abnormal development of inter-region information integration capacity in preterm neonates.
[Keywords] Preterm neonates；Term infant；Brain volume；Brain structural network；Module pattern；Magnetic resonance imaging

JIN Chao# Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

HU Ya-jie# Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

LI Xian-jun Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

WANG Miao-miao Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

LI Yan-yan Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

CHENG Yan-nan Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

WANG Xiao-yu Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

TAO Xing-xing Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

ZHAO Hui-fang Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

YANG Jian* Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

#: These authors contributed equally to this work.

*Correspondence to: Yang J, Email: yj1118@mail.xjtu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Research and Development Program of China No. 2016YFC0100300 National Natural Science Foundation of China No. 81471631, 81771810 and 51706178 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China No. NCET-11-0438 China Postdoctoral Science Foundation No. 2017M613145 Shaanxi Provincial Natural Science Foundation for Youths of China No. 2017JQ8005 Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University No. XJTU1AF-CRF-2015-004
Received  2018-03-23
Accepted  2018-04-24
DOI: 10.12015/issn.1674-8034.2018.06.003
DOI:10.12015/issn.1674-8034.2018.06.003.

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