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• Clinical Article •
Correlation of apparent diffusion coefficient for different b values with prognostic factors and subtypes of breast carcinoma
ZHANG Yue  LIU Wan-hua  WANG Rui  YE Yuan-yuan 

DOI:10.12015/issn.1674-8034.2018.06.005.


[Abstract] Objective: To investigate whether a correlation exists between apparent diffusion coefficient (ADC) obtained from magnetic resonance imaging diffusion weighted imaging (DWI) using different b values and different prognostic factors or immunohistochemical subtypes of breast cancers.Materials and Methods: The retrospective study included 81 patients with breast cancer. All patients were examined magnetic resonance imaging DWI using b values of 0, 400, 800 and 1000 s/mm2 and apparent diffusion coefficient (ADC) values were measured. All the patients underwent the immunohistochemistry after the operation, and were divided into different subtypes based on the immunohistochemical profile. The associations between ADC values and prognostic factors and subtypes of breast cancers were evaluated by using the independent-samples t test and the one-way analysis of variance (ANOVA) and Kruskal-Wallis test.Results: (1) For different b values, there was a statistically significance in different state of expression of ER, PR and HER2, except ER for b=400 s/mm2. (2) There was a positive correlation between ADC values for different b values and ER/PR positive, meanwhile it’s a negative correlation between ADC values for different b values and HER2 positive, except for b=400 s/mm2. The correlation coefficient of ADC values for b=800 s/mm2 and 1000 s/mm2 are higher than b=400 s/mm2. (3) For different b values, there was a statistically significance in ADC values between different immunohistochemical subtypes. There was a statistically significance for Luminal A and Luminal B between ADC values for different b values.Conclusions: The ADC value of DWI was correlated with the expression status of breast cancer prognosis factors and the subtypes of different molecules, and there is more significant correlation for high b values.
[Keywords] Diffusion weighted imaging；Prognostic factors；Molecular typing；Breast neoplasms；Magnetic resonance imaging；Apparent diffusion coefficient

ZHANG Yue Southeast University, Nanjing 210009, China

LIU Wan-hua* Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China

WANG Rui Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China

YE Yuan-yuan Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China

*Correspondence to: Liu WH, E-mail: liuwanhua.com@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Basic Research Development Plan (973 Project) No.2014CB744504
Received  2018-01-14
Accepted  2018-04-02
DOI: 10.12015/issn.1674-8034.2018.06.005
DOI:10.12015/issn.1674-8034.2018.06.005.

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