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• Original Article •
Magnetic resonance imaging study on the structural changes of anterior and posterior hippocampal subfields in schizophrenia patients
GUO Pan-fei  LI Xin-wei  LI Shu-yu 

DOI:10.12015/issn.1674-8034.2018.06.007.


[Abstract] Objective: This study aims at investigating the changes of anterior and posterior hippocampal formation in patients with schizophrenia using structural magnetic resonance imaging (MRI) technique, and exploring the pathophysiological mechanism of cognitive disorders.Materials and Methods: A total of 72 schizophrenia patients and 74 healthy controls were included in our present study. We compared the volume differences in the whole hippocampus, anterior hippocampus, and posterior hippocampus between patients and controls, using age and sex as covariates, and further analyzed the correlations among clinical cognitive scores and the volumes which were significantly different between two groups.Results: (1) The volumes of hippocampus, anterior hippocampus and posterior hippocampus on both sides (left and right) of the patients group were significantly smaller than those of the control group (P<0.05). (2) In patient group, the posterior hippocampal volume was positively correlated with verbal learning ability, and the anterior hippocampal volume on the right side was positively correlated with reasoning/problem solving ability.Conclusions: The atrophy patterns of anterior and posterior hippocampus we found in this study, provided new evidences for understanding the pathophysiology of cognitive impairment in schizophrenia patients.
[Keywords] Schizophrenia；Magnetic resonance imaging；Hippocampus；Cognition disorders

GUO Pan-fei School of Biological Science & Medical Engineering, Beihang University, Beijing 100083, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China

LI Xin-wei School of Biological Science & Medical Engineering, Beihang University, Beijing 100083, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China

LI Shu-yu* School of Biological Science & Medical Engineering, Beihang University, Beijing 100083, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China

*Correspondence to: Li SY, E-mail: shuyuli@buaa.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81471731
Received  2018-03-28
Accepted  2018-04-30
DOI: 10.12015/issn.1674-8034.2018.06.007
DOI:10.12015/issn.1674-8034.2018.06.007.

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