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Predictive value of ADC value in radiotherapy of primary brain lymphoma
SHI Da  SHI Ya-nan  ZHAN Wen-hua  YANG Xu-juan  ZHANG Pan  LI Jian  XU Meng-ying  CHEN Bing 

DOI:10.12015/issn.1674-8034.2018.06.011.


[Abstract] Objective: To investigate the predictive value of pretherapeutic apparent diffusion coefficient (ADC) value in the diffusion-weighted imaging for radiotherapy of primary brain lymphoma.Materials and Methods: 20 patients, from 2009 to 2017, in General Hospital of Ningxia Medical University clinical examination without history of immunodeficiency disease were collected, which were clinically and biopsy confirmed as diffuse large B cell lymphoma. The maximum diameter of enhanced lesion were measured from axial enhanced T1WI, before and after the radiotherapy, via which the tumor regression rate can be calculated. Then the primary brain lymphoma can be divided into two groups, called as complete remission (CR) group and non-complete remission (non-CR) group, via tumor regression rate. The minimum ADC (ADCmin) value, the average ADC (ADCmean) value, the maximum ADC (ADCmax) value of the lesion before radiotherapy were measured, the various ADC value in two groups were analyzed using statistical approach.Results: The difference between ADCmin value and ADCmean value before radiotherapy was statistically significant (P<0.05) between CR group and non-CR group, while ADCmax value had no significant difference between the two groups. ADCmin value and ADCmean value correlated with tumor regression rate, while each value were greater than 0.602×10-3 mm2/s, 0.800×10-3 mm2/s, the patients can be achieved CR effect after the completion of the radiotherapy cycle.Conclusions: ADCmin value and ADCmean value can be used as imaging biomarkers to predict the radiotherapy efficacy of the primary brain lymphoma.
[Keywords] Brain；Lymphoma；Apparent diffusion coefficient；Radiotherapy；Magnetic resonance imaging

SHI Da Ningxia Medical University, Yinchuan 750004, China

SHI Ya-nan Ningxia Medical University, Yinchuan 750004, China

ZHAN Wen-hua Department of Radiotherapy, Cancer Hospital, General Hospital of Ningxia Medical University, Yinchuan 750004, China

YANG Xu-juan Ningxia Medical University, Yinchuan 750004, China

ZHANG Pan Ningxia Medical University, Yinchuan 750004, China

LI Jian Ningxia Medical University, Yinchuan 750004, China

XU Meng-ying Ningxia Medical University, Yinchuan 750004, China

CHEN Bing* Department of Radiology, Cancer Hospital, General Hospital of Ningxia Medical University, Yinchuan 750004, China

*Correspondence to: Chen B, E-mail: 2269415835@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Ningxia Natural Science Foundation No. NZ15146
Received  2018-01-17
Accepted  2018-03-28
DOI: 10.12015/issn.1674-8034.2018.06.011
DOI:10.12015/issn.1674-8034.2018.06.011.

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