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• Clinical Article •
Changes of local brain neural function activity in subjective tinnitus based on resting-state functional MRI
HAN Qi  LIU Dai-hong  WANG Yao  FENG Ya-jin  WANG Jian 

DOI:10.12015/issn.1674-8034.2018.07.001.


[Abstract] Objective: To explore the alterations of local spontaneous brain function activity in patients with subjective tinnitus (ST) using regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) approaches.Materials and Methods: Twenty-five patients with ST and 25 age-, sex-, and education-matched normal controls were included in the study. All participants underwent resting-state functional magnetic resonance imaging (fMRI) scans. Both ReHo and fALFF values were calculated to represent local spontaneous brain activity and were compared between groups. Correlational analyses were then conducted to investigate the relationship between these two methods and clinical scale data in ST patients.Results: Compared with normal controls, ST patients showed significantly increased ReHo and fALFF values in the right middle temporal gyrus (MTG) and cuneus, while decreased ReHo values were found in the right middle frontal gyrus (MFG) and left anterior lobe of the cerebellum (P<0.05, GRF correction). In the ST group, ReHo values of the right MTG were positively correlated with the tinnitus handicap inventory (THI) score (r=0.576, P=0.003).Conclusions: ST patients showed abnormal spontaneous brain activity in some auditory and non-auditory brain regions, mainly involving the default mode network and audio-visual network, which could confirm that ST exists the aberrant changes of local spontaneous brain neural function activity.
[Keywords] Tinnitus；Brain；Magnetic resonance imaging

HAN Qi Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

LIU Dai-hong Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

WANG Yao Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

FENG Ya-jin Department of Otolaryngology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

WANG Jian* Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

*Correspondence to: Wang J, E-mail: wangjian_811@yahoo.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Research and Development Program of China No. 2016YFC0107100
Received  2018-03-01
Accepted  2018-05-07
DOI: 10.12015/issn.1674-8034.2018.07.001
DOI:10.12015/issn.1674-8034.2018.07.001.

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