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• Clinical Article •
Effects of KIBRA polymorphism on the volume of hippocampus subfield in healthy young volunteers
LIANG Xue  WANG Fang-fang  WANG Kun  ZHANG Qing-lei  WU Si-chu  QING Zhao  ZHANG Xin  LI Ming  ZHANG Bing 

DOI:10.12015/issn.1674-8034.2018.07.004.


[Abstract] Objective: To investigate the effect of kidney and brain expressed protein (KIBRA) rs17070145 gene polymorphism on the volume of hippocampus subfield in healthy young volunteers by using the MR automatic segmentation method.Materials and Methods: A total of 60 healthy young volunteers were recruited in the study according to volunteer recruitment process criterion. Subjects were divided into two groups according to the genotype test: one group was the C allele carriers (CC+CT) and another group was the TT homozygous carriers. All subjects underwent the head magnetic resonance imaging, 23 subjects of who were assessed by the neuropsychological scale. The volume of the hippocampal subfields were segmented and calculated by FreeSurfer V5.3.0 software from the 3D-T1 weighted imaging sequence. The differece of each hippocampal subfield volume was compared between the two groups by using the linear regression analysis, controlling for eTIV (estimated total intracranial volume). The eTIV was used as the covariate in this analysis to remove the difference of hippocampal volume caused by the size of each subject. The Pearson correlation test was used between the volume of the hippocampus subfield and the neuropsychological scale.Results: Compared with TT homozygote carriers, the volume of the left CA1 region volume of the C allele group was significantly increased (P=0.032). No significant differences were found between the two groups in other hippocampal subfields. And there was a significant positive correlation between the volume of the left CA1 region volume and the complete time of digital connection test-B (NCT-B) (r=0.459, P=0.028) in 23 volunteers.Conclusions: In the young healthy volunteers, the volume of the left CA1 region is affected by the KIBRA gene polymorphism. The increased volume of left CA1 region in the C allele carriers may be a compensatory effect on the reduction of spatial memory and execution function, which will be helpful to study the neural mechanisms of KIBRA gene polymorphism and spatial memory and execution function on healthy young people.
[Keywords] Hippocampus；Genes；Polymorphism, genetic；Magnetic resonance imaging

LIANG Xue Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

WANG Fang-fang Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

WANG Kun Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Qing-lei Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

WU Si-chu Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

QING Zhao Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Xin Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

LI Ming Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Bing* Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

*Correspondence to: Zhang B, E-mail: zhangbing_nanjing@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the National Natural Science Foundation of China No. 81720108022, 91649116, 81571040
Received  2018-03-11
Accepted  2018-05-10
DOI: 10.12015/issn.1674-8034.2018.07.004
DOI:10.12015/issn.1674-8034.2018.07.004.

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