Share：
Share this content in WeChat
X
[Chinese][PDF]102894
• Clinical Article •
Value of Gd-EOB-DTPA enhanced MRI in differentlly diagnosing malignant neoplasms from benign nodules of focal liver lesions
XU Yong-sheng  LIU Hai-feng  LI Jin-Kui  Wang Meng-shu  NAN Jiang  GUO Qi-Hong  LEI Jun-qiang 

DOI:10.12015/issn.1674-8034.2018.07.005.


[Abstract] Objective: To evaluate the values of unenhanced MRI, high-b-value diffusion-weighted imaging (DWI) and Gd-EOB-DTPA enhanced MRI in diagnosis of focal liver lesions.Materials and Methods: Sixty-eight patients with 96 focal hepatic lesions were enrolled in this study. The images were analyzed by three methods: method A included the combined reading of unenhanced, DWI images, method B considered unenhanced, dynamic enhanced phase images, method C considered unenhanced, DWI, dynamic enhanced phase and hepatobiliary phase images. Two experienced abdominal radiologists who were independent reviewed the images. Sensitivity and specificity were cmpared by χ2 test.Results: Histopathology of the lesions,there were hepatocellular carcinoma (HCC, n=47), dysplastic nodule (DN, n=12), hemangioma (n=10), intrahepatic cholangiocarcinoma (ICC, n=8), intrahepatocellular carcinoma-cholangiocarcinoma (HCC-ICC, n=6), regenerative nodule (RN, n=7), malignant lymphoma (n=2) and metastases, lymphoid follicular hyperplasia, abscess, adenoma for one case each. 61, 61, 64 malignant neoplasms were characterized by methods A, B and C, respectively. The sensitivity, specificity was 87.5% (56/64), 50.0% (16/32), 71.9% (46/64), 75.0% (24/32), 96.9% (62/64), 75.0% (24/32) respectively. The sensitivity and specificity of diagnosing malignant lesions of liver in three groups were statistically different (P< 0.05) except for the difference in the specificity between group B and group C (P=1).Conclusions: Gd-EOB-DTPA enhanced MRI, unenhanced MRI and high-b-value diffusion-weighted imagings (DWI) showed typical imaging features, which were best sanning methods in diagnosis of focal liver lesions.
[Keywords] Liver neoplasms；Magnetic resonance imaging；Contrast media

XU Yong-sheng Radiology Department, the First Hospital of Lanzhou University, Lanzhou 73000, China; The First Clinical Medical College of Lan Zhou University, Lanzhou 73000, China

LIU Hai-feng Radiology Department, the First Hospital of Lanzhou University, Lanzhou 73000, China; The First Clinical Medical College of Lan Zhou University, Lanzhou 73000, China

LI Jin-Kui Radiology Department, the First Hospital of Lanzhou University, Lanzhou 73000, China

Wang Meng-shu Radiology Department, the First Hospital of Lanzhou University, Lanzhou 73000, China; The First Clinical Medical College of Lan Zhou University, Lanzhou 73000, China

NAN Jiang Radiology Department, the First Hospital of Lanzhou University, Lanzhou 73000, China

GUO Qi-Hong Radiology Department, the First Hospital of Lanzhou University, Lanzhou 73000, China

LEI Jun-qiang* Radiology Department, the First Hospital of Lanzhou University, Lanzhou 73000, China

*Correspondence to: Lei JQ, E-mail: leijq1990@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is funded by the Gansu Provincial Natural Science Foundation of China No. 1506RJZA265
Received  2018-02-13
Accepted  2018-03-15
DOI: 10.12015/issn.1674-8034.2018.07.005
DOI:10.12015/issn.1674-8034.2018.07.005.

[1]
Zuo T, Zheng R, Zeng H, et al. Analysis of liver cancer incidence and trend in China. Zhonghua Zhong Liu Za Zhi, 2015, 37(9): 691-696.
[2]
Golabi P, Fazel S, Otgonsuren M, et al. Mortality assessment of patients with hepatocellular carcinoma according to underlying disease and treatment modalities. Medicine, 2017, 96(9): e5904.
[3]
Filipe JP, Curvo-Semedo L, Casalta-Lopes J, et al. Diffusion-weighted imaging of the liver: usefulness of ADC values in the differential diagnosis of focal lesions and effect of ROI methods on ADC measurements. Magma, 2013, 26(3): 303-312.
[4]
Kaya B, Koc Z. Diffusion-weighted MRI and optimal b-value for characterization of liver lesions. Acta radiologica, 2014, 55(5): 532-542.
[5]
雷军强，马文婷，王寅中，等．特异性肝胆对比剂钆塞酸二钠对肝转移瘤的诊断价值的Meta分析．中国循证医学杂志, 2015(12): 1378-1386.
[6]
Junqiang L, Yinzhong W, Li Z, et al. Gadoxetic acid disodium (Gd-EOBDTPA)-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: a meta-analysis. J Magnc Reson imaging, 2014, 39(5): 1079-1087.
[7]
Park MJ, Kim YK, Lee MW, et al. Small hepatocellular carcinomas: improved sensitivity by combining gadoxetic acid-enhanced and diffusion-weighted MR imaging patterns. Radiology, 2012, 264(3): 761-770.
[8]
Lee MH, Kim SH, Park MJ, et al. Gadoxetic acid-enhanced hepatobiliary phase MRI and high-b-value diffusion-weighted imaging to distinguish well-differentiated hepatocellular carcinomas from benign nodules in patients with chronic liver disease. AJR Am J Roentgenol, 2011, 197(5): W868-875.
[9]
Calistri L, Castellani A, Matteuzzi B, et al. Focal liver lesions classification and characterization: what value do dwi and adc have? J Comput Sssist Tomogr, 2016, 40(5): 701-708.
[10]
Chen ZG, Xu L, Zhang SW, et al. Lesion discrimination with breath-hold hepatic diffusion-weighted imaging: a meta-analysis. World J Gastroenterol, 2015, 21(5): 1621-1627.
[11]
Jiang T, Xu JH, Zou Y, et al. Diffusion-weighted imaging (DWI) of hepatocellular carcinomas: a retrospective analysis of the correlation between qualitative and quantitative DWI and tumour grade. Clin Radiol, 2017, 72(6): 465-472.
[12]
丁丁，陆健，黎美玲，等．肝功能正常患者Gd-EOB-DTPA增强MRI肝胆期延迟时间的研究．磁共振成像, 2015, 6(10): 757-761.
[13]
Guo J, Seo Y, Ren S, et al. Diagnostic performance of contrast-enhanced multidetector computed tomography and gadoxetic acid disodium-enhanced magnetic resonance imaging in detecting hepatocellular carcinoma: direct comparison and a meta-analysis. Abdom Radiol, 2016, 41(10): 1960-1972.
[14]
赵丽，赵心明．磁共振成像在肝内胆管细胞癌的诊断及疗效评估中的研究进展．磁共振成像, 2017, 8(10): 791-795.
[15]
Schelhorn J, Best J, Dechêne A, et al. Evaluation of combined Gd-EOB-DTPA and gadobutrol magnetic resonance imaging for the prediction of hepatocellular carcinoma grading. Acta Radiol, 2016, 57(8): 932-938.
[16]
Lewis S, Besa C, Wagner M, et al. Prediction of the histopathologic findings of intrahepatic cholangiocarcinoma: qualitative and quantitative assessment of diffusion-weighted imaging. Eur Radiol, 2018, 28(5): 2047-2057.
[17]
Li X, Li C, Wang R, et al. Combined application of gadoxetic acid disodium-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the diagnosis of chronic liver disease-induced hepatocellular carcinoma: a Meta-analysis. PLoS One, 2015, 10(12): e0144247.

PREV Effects of KIBRA polymorphism on the volume of hippocampus subfield in healthy young volunteers
NEXT Preliminary application of gadolinium-based capsule in MR colon transit times
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn