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• Clinical Article •
Preliminary application of gadolinium-based capsule in MR colon transit times
XIONG Fei  WANG Xin-hua  QIU Jian-ping  ZHI Min  CHEN Huang-wei  ZHU Pan  ZHOU Zhi-yang 

DOI:10.12015/issn.1674-8034.2018.07.006.


[Abstract] Objective: Radio-opaque markers (ROMs) is a commonly used traditional method for colon dynamics. As the limitation of ionizing radiation of ROMs in clinical use, we proposed a method of gadolinium-based capsules in the measurement of colon dynamics. It can be used in semi-quantitative analysis of digestive tract transmitting ability in a non-invasive way and free of ionizing radiation.Materials and Methods: Twenty healthy volunteers without acute or chronic gastrointestinal function disorders and 5 slow transit constipation patients consumed 5 gadolinium-based capsules simultaneously. Gadolinium-based capsules contained gadolinium/0.9% normal saline (concentration ratio is 1﹕10). After ingestion of capsules, T1WI LAVA sequences using a 1.5 Tesla MR system is obtained at certain time point until all capsules were emptied completely. The location of capsules is analyzed via these imaging data.Results: All of the twenty healthy volunteers (average age: 33 years) and five slow transit constipation patients (average age: 34 years) successfully underwent MRI colonic transit tests without any discomfort. In healthy volunteers group, the mean transit time is (32.3±18.9) hour. For slow transit constipation patients, the mean transit time is (64.8±9.6) hour, and it is obviously longer than it in healthy group. The best sequence in MR imaging is defined in T1WI sequence.Conclusions: MRI colon transit times is capable of duplicating the result of X-ray colon transit times accurately. Meanwhile, MR colon transit times is free of ionizing radiation with abundant imaging information. It can clearly demonstrate the morphology of colon, location and semi-quantify the remaining markers in the colon. In future, it can be possible dynamic evaluation of the digestive tract transit time and applied to clinical routine.
[Keywords] Colon transit time；Radio-opaque marker；Magnetic resonance imaging；Colon transit dynamics；Gadolinium-based capsule

XIONG Fei Department of Radiology, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

WANG Xin-hua Department of Radiology, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

QIU Jian-ping Department of Radiology, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

ZHI Min Department of Gastroenterology, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

CHEN Huang-wei Department of Gastroenterology, People's Hospital of Nanhai District, Foshan, Guangdong Province, Foshan 528200, China

ZHU Pan Department of Radiology, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

ZHOU Zhi-yang* Department of Radiology, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

*Correspondence to: Zhou ZY, E-mail: zhouzyang@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Natural Science Foundation of Guangdong Province of China No. 2015A030313109 Science and Technology Program of Guangzhou, China: Special Project on the Integration of Industry, Education and Research of Guangzhou No. 201704030082
Received  2018-03-24
Accepted  2018-05-20
DOI: 10.12015/issn.1674-8034.2018.07.006
DOI:10.12015/issn.1674-8034.2018.07.006.

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