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The role of metal ions in AD pathogenesis and its imaging evaluation
ZHANG Cong  WANG Xiao-ming 

DOI:10.12015/issn.1674-8034.2018.07.011.


[Abstract] The main pathogenesis of Alzheimer's disease is the abnormal accumulation of beta-amyloid and the abnormal phosphorylation of Tau protein causes neurofibrillary tangles. Metal ions play an important role in the formation of β beta plaque. With the development of imaging technology, it is possible to evaluate the abnormal deposition of beta-amyloid and tangles of neurofibrillary fibers. This paper reviews the mechanism of metal ions and the status of imaging evaluation.
[Keywords] Alzheimer disease；Metals；Ions；Plaque, amyloid；Neurofibrillary tangles；Magnetic resonance imaging

ZHANG Cong Department of Radiology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China

WANG Xiao-ming* Department of Radiology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China

*Corresponding to: Wang XM, E-mail: wangxm024@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of the National Natural Science Foundation of China No. 81471720 Basic Research Project of Key Laboratory of Educationg Department of Liaoning Province No. LZ2014039 Outstanding Scientific Fund of Shengjing Hospital No. 201402
Received  2018-03-08
Accepted  2018-04-08
DOI: 10.12015/issn.1674-8034.2018.07.011
DOI:10.12015/issn.1674-8034.2018.07.011.

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