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• fMRI •
Functional connectivity of persistent somatoform pain disorder in thalamus: A functional magnetic resonance imaging study
CHEN Da-jie  YANG Hai-long  WANG Zheng-ge  XIANG Xiao-ping  TAO Gao-jian  ZHANG Bing 

DOI:10.12015/issn.1674-8034.2018.08.001.


[Abstract] Objective: To investigate the relationship between thalamus and whole brain functional connectivity in patients with persistent somatoform pain disorder (PSPD) and to explore the relationship between PSPD functional connectivity strength and pain level.Materials and Methods: 18 patients with PSPD and 16 healthy controls with matched age, sex, and education levels were enrolled in resting state functional magnetic resonance scan. We separately choose bilateral thalamus as ROI and observe the functional connections between the thalamus and the whole brain in both PSPD patients and healthy controls. Furthermore, Pearson's linear correlation analysis was performed with varying functional connections and pain level.Results: Compared with the healthy controls, the functional connectivity between the thalamus and the left triangle inferior frontal gyrus, left orbital inferior frontal gyrus, left putamen, and the left caudate was enhanced in PSPD. However, the functional connectivity between the left thalamus and the right inferior temporal gyrus was decreased. In addition, the functional connectivity between the right thalamus and the left caudate was significantly negatively correlated with pain level.Conclusions: There are abnormalities in thalamus-related functional connections in PSPD, which may be one of the causes of the persistent somatoform pain.
[Keywords] Persistent somatoform pain disorder；Thalamus；Functional connectivity；Magnetic resonance imaging, functional

CHEN Da-jie Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

YANG Hai-long Department of Psychology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

WANG Zheng-ge Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

XIANG Xiao-ping Department of Pain, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

TAO Gao-jian Department of Pain, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Bing* Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

*Correspondence to: Zhang B, E-mail: zhangbing_nanjing@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Social Development Project of Jiangsu Science and Technology Plan Project No. BE2016605, BE201707 Nanjing University of Public Health Project General Project No.YKK16072 Research Project of Nanjing Science and Technology Bureau No. 201715024
Received  2018-03-26
Accepted  2018-06-08
DOI: 10.12015/issn.1674-8034.2018.08.001
DOI:10.12015/issn.1674-8034.2018.08.001.

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