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• Clinical Article •
Application of MRI diffusion tensor imaging in temporal lobe focal cortical dysplasia
SHAN Chun-hui  BAO Yun-feng  LIU Xi  SUN Ji-lin 

DOI:10.12015/issn.1674-8034.2018.08.006.


[Abstract] Objective: To investigate the diagnostic value of diffusion tensor imaging (DTI) in focal cortical dysplasia (FCD).Materials and Methods: A total of 45 patients confirmed by pathology of FCD and 45 healthy controls were involved in this study. After reviewing their magnetic resonance imaging (MRI) and DTI imaging data, the fraction anisotropy (FA) and apparent diffusion coefficient (ADC) values measured in typical lesions and symmetrical area and the same side of healthy controls. Pearson test was used to test the correlation between the FA and ADC values in the bilateral cortical and white matter areas of the patients. Duncan test was used to test difference between the results of two parameters of different types of FCD. Paired t test was used to compare the data difference between the patient side and the healthy side, and the same side area of the control group. Receiver operating characteristic curve (ROC) was drawn to compare the ability of MRI scan and DTI to detect FCD positive expression in cortical group.Results: The results of Pearson test showed that there was no significant correlation between the measured values of FA and ADC in the cortex (P>0.05), and there was a negative correlation between the values of the white matter region (P<0.05). The results of Duncan variance analysis showed that there was no significant difference in the measured values of FA and ADC of different types of FCD (P>0.05). Paired t test results showed that: for FA measurements, there was no significant difference (P>0.05) between the cortex diseased side and the healthy side and the ipsilateral area of control group, while the values of the white matter diseased side were significantly lower than those in the contralateral side and the ipsilateral area of control groups (P <0.05); for ADC measurements, the diseased side of cortex and white matter values both were significantly higher than that of the healthy side and the ipsilateral area of contorl group (P<0.05). The results of McNemar test showed that the positive detection rate of ADC value (77.8%) in cortical area was more sensitive than MRI and FA. Kappa consistency test showed that the detection ability of ADC value (Kappa=0.802, P<0.05) was the highest with FCD pathology.Conclusions: The pathological findings of FCD in cortex and white matter are quite different. FA and ADC can reflect the microscopic structure details of the tissue to varying degrees, but they are poorly effective in assisting the pathological typing. DTI technology, especially ADC value, can provide unique value for the diagnosis of FCD, it is recommended to be widely used in clinical practice.
[Keywords] Magnetic resonance imaging；Forcal cortical dysplasias；Diffusion tensor imaging；Cortex；Temporal lobe

SHAN Chun-hui Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

BAO Yun-feng Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

LIU Xi Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

SUN Ji-lin* Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

*Correspondence to: Sun JL, E-mail: sunjilin2020@126.com

Conflicts of interest   None.

Received  2018-02-14
Accepted  2018-04-14
DOI: 10.12015/issn.1674-8034.2018.08.006
DOI:10.12015/issn.1674-8034.2018.08.006.

[1]
Mellerio C, Labeyrie MA, Chassoux F, et al. Optimizing MR imaging detection of type 2 focal cortical dysplasia: best criteria for clinical practice. AJNR Am J Neuroradiol, 2012, 33(10): 1932-1938.
[2]
Hemb M, Velasco TR, Parnes MS, et al. Improved outcomes in pediatric epilepsy surgery. Neurology, 2010, 74(22): 1768-1775.
[3]
Moritz K, Véronique S, Daniel S, et al. Peripheral nerve diffusion tensor imaging (DTI): normal values and demographic determinants in a cohort of 60 healthy individuals. Eur Radiol, 2018, 28(5): 1801-1808.
[4]
Lilja Y, Gustafsson O, Ljungberg M, et al. Impact of ROI method on quantitative analysis of DTI. BMC Med Imaging, 2016, 16(1): 42.
[5]
Colombo N, Salamon N, Raybaud C, et al. Imaging of malformations of cortical development. Epileptic Disorders, 2009, 11(3): 194-205.
[6]
Diehl B, Tkach J, Piao Z, et al. Diffusion tensor imaging in patients with focal epilepsy due to cortical dysplasia in the temporo-occipital region: electro-clinico-pathological correlations. Epilepsy Research, 2010, 90(3): 178-187.
[7]
Braovich AJ, Guerrini R, Kuzniecky RI, et al. A developmental and genetic classification for malformations of cortical development: update2012. Brain, 2012, 135(Pt 5): 1348-1369.
[8]
李永欣，刘哲星，黄文华．扩散张量成像数据分析方法概述．中国医学影像技术, 2015, 31(6): 953-956.
[9]
Toktas ZO, Tanrikulu B, Koban O, et al. Diffusion tensor imaging of cervical spinal cord: A quantitative diagnostic tool in cervical spondylotic myelopathy. J Craniovertebr Junction Spine, 2016, 7(1): 26-30.
[10]
Le-Bihan D, Mangin JC, Clark C, et al. Diffusion tensor imaging: Concepts and applications. J Magn Reson Imaging, 2001, 13(4): 534-546.
[11]
Blümcke I, Thom M, Aronica E, et al. The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc task force of the ILAE diagnostic methods commission. Epilepsia, 2011, 52(1): 158-174.
[12]
Widjaja E, Geibprasert S, Otsubo H, et al. Diffusion tensor imaging assessment of the epileptogenic zone in children with localization-related epilepsy. AJNR Am J Neuroradiol, 2011, 32(10): 1789-1794.
[13]
马明平, Ritter John L,江紫荣，等．局灶性脑皮质发育不良的扩散张量成像初步研究．中华放射学杂志, 2010, 44(3): 234-238.
[14]
Becker AJ, Beck H. New developments in understanding focal cortical malformations. Curr Opin Neurol, 2018, 31(2): 151-155.
[15]
Lee JH, Chung CK, Song IC, et al. Limited utility of interictal apparent diffusion coefficient in the evaluation of hippocampal sclerosis. Acta Neurol Scand, 2004, 110(1): 53-58.
[16]
Bast T, Ramantani G, Seitz A, et al. Focal cortical dysplasia: prevalence, clinical presentation and epilepsy in children and adults. Acta Neurol Scand, 2006, 113(2): 72-81.
[17]
朱劲龙，李嘉佳，朱海涛，等．磁共振阴性的局灶性脑皮质发育不良的手术治疗．临床神经外科杂志, 2014, 11(6): 412-415.
[18]
Rowland NC, Englot DJ, Cage TA, et al. A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia. J Neurosurg, 2012, 116(5): 1035.
[19]
Chen Q, Lui SC, Jiang L, et al. MRI-negative refractory partial epilepsy: role for diffusion tensor imaging in high field MRI. Epilepsy Res, 2008, 80(1): 83.

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