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• Clinical Article •
Preliminary evaluation of main pulmonary artery changes in CMS patients with phase contrast MR imaging
WANG Wen  BAO Hai-hua 

DOI:10.12015/issn.1674-8034.2018.08.007.


[Abstract] Objective: To evaluate the clinical application value of structure and hemodynamics of main pulmonary artery (MPA) and mean pulmonary artery pressure (MPAP) in patients with chronic mountain sickness (CMS) by using phase contrast MR imaging (PC-MRI).Materials and Methods: 22 male adult patients with CMS (CMS group) and 20 healthy male adult volunteers (control group) from the same altitude were recruited. The 2D/QF sequence of Philips 1.5 T magnetic resonance scanner was used for main pulmonary artery to obtain its cross-sectional area (CSA), peak positive velocity (PPV), peak negative velocity (PNV), right ventricular stroke volume (RVSV) and regurgitant fraction (RF). Then, relative dilatation degree (RDD) and MPAP were calculated.Results: (1)Structure parameters: the CSA and RDD of CMS group were (7.52±0.71) cm2 and (36.11±11.27)% respectively, and those of the control group were (6.34±1.12) cm2 and (52.08±7.54)% respectively. CSA increased by (P<0.01) compared with the control group, and RDD decreased by (P<0.01). (2) Hemodynamics parameters: the PPV, PNV, RVSV and RF of the CMS group were (72.19±9.41) cm/s, (28.61±4.16), (64.43±21.48) ml and (7.11±0.93)% respectively, and those of the control group were (80.32±11.15) cm/s, (22.64±6.14), (59.12±19.34) ml and (4.31±0.48)% respectively. The PPV decreased by (P=0.015) compared with the control group, the PNV increased by (P< 0.01), the RVSV increased by (P=0.411), the RF increased by (P=0.004). (3)MPAP (36.71±12.36) mmHg in the CMS group was significantly higher than that (15.77±6.69) mmHg in the control group by (P<0.01).Conclusions: Long-term hypobaric and hypoxic conditions in CMS patients resulted in MPA dilatation, flexibility decrease, changes of blood flow velocity and increase of RF and MPAP. PC-MRI can non-invasively and accurately provide the information of the MPA structure, hemodynamics and pressure, so as to preliminarily achieve the purpose of assessment of the characteristics of the MPA changes in CMS patients.
[Keywords] Chronic mountain sickness；Pulmonary hypertension；Hemodynamics；Magnetic resonance imaging

WANG Wen Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi' ning 810001, China

BAO Hai-hua* Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi' ning 810001, China

*Correspondence to: Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foudation of China No. 81260216 and Science and Technology Project of Qinghai Province No. 2017-SF-158
Received  2018-05-07
Accepted  2018-06-08
DOI: 10.12015/issn.1674-8034.2018.08.007
DOI:10.12015/issn.1674-8034.2018.08.007.

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