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• Clinical Article •
Application of quantitative parameters of dynamic contrast-enhanced MRI in the diagnosis of early prostate cancer
ZHANG Xu-hui  LIANG Wen  LI Xin-ming  QUAN Xian-yue 

DOI:10.12015/issn.1674-8034.2018.08.009.


[Abstract] Objective: To evaluate the diagnostic value of quantitative parameters of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for early prostate cancer, and evaluate the correlation among quantutative parameters and microvascular density (MVD), Gleason score.Materials and Methods: Eighty-five patients with prostatic diseases, including 49 patients with early prostate cancer and 36 patients with benign prostatic hyperplasia, undergoing DCE-MRI examination were enrolled in the study, region of interest (ROI) were drawn on areas of cancerous foci, hyperplasia in the central gland and noncancerous foci in the peripheral zone to measure the values of volume transfer contrast (Ktrans), rate contrast (Kep). The values of the two parameters in the different tissues were compared with Kruskal-Wallis H and Mann-Whitney U; the diagnosis vallue of each parameter for early prostate cancer was evaluated by receiver operating characteristic (ROC) curve; The correlation between the two parameters and MVD, Gleason score were assessed with Pearson correlation.Results: The values of Ktrans, Kep were (0.37±0.15) min-1, (1.29±0.29) min-1 respectively for cancerous foci, (0.32±0.12) min-1, (1.20±0.24) min-1 respectively for hyperplasia in the central gland and (0.15±0.59) min-1, (0.45±0.18) min-1 respectively for noncancerous foci in the peripheral zone. The values of Ktrans and Kep for cancerous foci and hyperplasia in the central gland obviously higher than those for noncancerous foci in the peripheral zone (P<0.05). The Ktrans and Kep of cancerous foci were not obviously higher than those for hyperplasia in the central gland (P>0.05). The area under curve (AUC) of Ktrans and Kep for early prostate cancer was 0.770 and 0.796 respectively. There were significantly positive correlation among the two parameters and MVD, Gleason score (P<0.05).Conclusions: The values of Ktrans and Kep have moderate value in the diagnosis of early prostate cancer, they can differentiate cancerous foci and peripheral zone noncancerous foci, but not differentiate cancerous foci and central gland hyperplasia. In addition, the value of Ktrans and Kep can be used as a prognostic indicator for patients with early prostate cancer.
[Keywords] Prostate neoplasms；Magnetic resonance imaging；Dynamic contrast-enhanced；Quantitative parameter

ZHANG Xu-hui* Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

LIANG Wen Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

LI Xin-ming Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

QUAN Xian-yue Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

*Correspondence to: Zhang XH, E-mail: xuhuizh1219@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Guangdong Science and Technology Planning Project No.2014A020212665
Received  2018-03-26
Accepted  2018-06-15
DOI: 10.12015/issn.1674-8034.2018.08.009
DOI:10.12015/issn.1674-8034.2018.08.009.

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