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• Clinical Article •
Application of quantitative parameters of dynamic contrast-enhanced MRI in the diagnosis of early prostate cancer
ZHANG Xu-hui  LIANG Wen  LI Xin-ming  QUAN Xian-yue 

DOI:10.12015/issn.1674-8034.2018.08.009.


[Abstract] Objective: To evaluate the diagnostic value of quantitative parameters of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for early prostate cancer, and evaluate the correlation among quantutative parameters and microvascular density (MVD), Gleason score.Materials and Methods: Eighty-five patients with prostatic diseases, including 49 patients with early prostate cancer and 36 patients with benign prostatic hyperplasia, undergoing DCE-MRI examination were enrolled in the study, region of interest (ROI) were drawn on areas of cancerous foci, hyperplasia in the central gland and noncancerous foci in the peripheral zone to measure the values of volume transfer contrast (Ktrans), rate contrast (Kep). The values of the two parameters in the different tissues were compared with Kruskal-Wallis H and Mann-Whitney U; the diagnosis vallue of each parameter for early prostate cancer was evaluated by receiver operating characteristic (ROC) curve; The correlation between the two parameters and MVD, Gleason score were assessed with Pearson correlation.Results: The values of Ktrans, Kep were (0.37±0.15) min-1, (1.29±0.29) min-1 respectively for cancerous foci, (0.32±0.12) min-1, (1.20±0.24) min-1 respectively for hyperplasia in the central gland and (0.15±0.59) min-1, (0.45±0.18) min-1 respectively for noncancerous foci in the peripheral zone. The values of Ktrans and Kep for cancerous foci and hyperplasia in the central gland obviously higher than those for noncancerous foci in the peripheral zone (P<0.05). The Ktrans and Kep of cancerous foci were not obviously higher than those for hyperplasia in the central gland (P>0.05). The area under curve (AUC) of Ktrans and Kep for early prostate cancer was 0.770 and 0.796 respectively. There were significantly positive correlation among the two parameters and MVD, Gleason score (P<0.05).Conclusions: The values of Ktrans and Kep have moderate value in the diagnosis of early prostate cancer, they can differentiate cancerous foci and peripheral zone noncancerous foci, but not differentiate cancerous foci and central gland hyperplasia. In addition, the value of Ktrans and Kep can be used as a prognostic indicator for patients with early prostate cancer.
[Keywords] Prostate neoplasms；Magnetic resonance imaging；Dynamic contrast-enhanced；Quantitative parameter

ZHANG Xu-hui* Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

LIANG Wen Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

LI Xin-ming Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

QUAN Xian-yue Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

*Correspondence to: Zhang XH, E-mail: xuhuizh1219@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Guangdong Science and Technology Planning Project No.2014A020212665
Received  2018-03-26
Accepted  2018-06-15
DOI: 10.12015/issn.1674-8034.2018.08.009
DOI:10.12015/issn.1674-8034.2018.08.009.

[1]
马露，叶慧义，王海屹．动态增强MRI定量分析在前列腺癌诊断中的应用．微创泌尿外科杂志, 2017, 6(2): 119-123.
[2]
Li CM, Chen M, Li SY, et al. Detection of prostate cancer in peripheral Zone: comparison of MR diffusion tensor imaging, quantitative dynamic contrast-enhanced MRI, and the two techniques combined at 3.0 T. Acta Radiologica, 2014, 55(2): 239-247.
[3]
黄云海，郭永梅，徐宏刚，等．磁共振动态增强TIC曲线及Ktrans值在前列腺癌诊断中的对比．放射学实践, 2016, 31(6): 511-515.
[4]
李烨，刘爱连，孙美玉，等. 3.0 T动态对比增强MRI对前列腺癌与前列腺增生的鉴别价值．实用放射学杂志, 2016, 32(11): 1717-1720.
[5]
Yuan Q, Costa DN, Senegas J, et al. Quantitative diffusion-weighted imaging and dynamic contrast-enhanced characterization of the index lesion with multiparametric MRI in prostate cancer patients. J Magn Reson Imaging, 2017, 45(3): 908-916.
[6]
Elbuluk Q, Muradyan N, Shih J, et al. Differentiating transition zone cancers from benign prostate hyperplasia by quantitative multiparametric magnetic resonance imaging. J Comput Assist Tomogr, 2016, 40(2): 218-224.
[7]
刘会佳，赵娓娓，任芳，等. 3.0 T动态增强MRI对前列腺癌的定量分析研究．放射学实践, 2014, 29(5): 477-481.
[8]
何为，刘毅，刘剑羽，等. 3.0 T MR动态增强扫描定量分析诊断前列腺癌的价值．中华放射学杂志, 2014, 48(3): 215-218.
[9]
马向征，王世威，许茂盛，等. DCE-MRI联合DWI定量分析在前列腺癌诊断的应用价值．浙江医学, 2017, 39(1): 7-11.
[10]
何永胜，戚轩，许敏，等．扩散加权成像联合动态增强MRI诊断前列腺癌的定量分析研究．肿瘤影像学, 2017, 26(3): 221-226.
[11]
Cho E, Chung DJ, Yeo DM, et al. Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score. Clin Imaging, 2015, 35(5): 834-840.
[12]
Grivas N, Goussia A, Stefanou D, et al. Microvascular density and immunohistochemical expression of VEGF, VEGFR-1 and VEGFR-2 in benign prostatic hyperplasia, high-grade prostate intraepithelial neoplasia and prostate cancer. Cent European J Urol, 2016, 69(1): 63-71.
[13]
Schlemmer HP, Merkle J, Grobholz R, et al. Can pre-operative contrast-enhanced dynamic MR imaging for prostate cancer predict microvessel density in prostatectomy specimens?. Eur Radiol, 2004, 14(2): 309-317.
[14]
温茹，赵文露，魏超刚，等．动态增强MRI和扩散加权成像定量参数直方图与前列腺癌Gleason评分的相关性．中华放射学杂志, 2017, 51(5): 355-361.
[15]
van Niekerk CG, van der Laak JA, Hambrock T, et al. Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer. Eur Radiol, 2014, 24(10): 2597-2605.
[16]
徐嬿，冷晓明，郑芸，等. 3.0 T DCE-MRI定量分析在前列腺癌与增生鉴别诊断中的应用价值．磁共振成像, 2015, 6(8): 608-612.

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