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• Clinical Article •
Diagnostic value of cerebrospinal fluid 1H-MRS for mitochondrial encephalopathy
ZHOU Zhi-ling  LU Jie-yan  XING Wu  HU Ping  LIAO Wei-hua 

DOI:10.12015/issn.1674-8034.2018.09.001.


[Abstract] Objective: To investigate the diagnostic value of cerebrospinal fluid 1H-MRS for mitochondrial encephalopathy and provide new clues and ideas for clinical diagnosis.Materials and Methods: Thirteen patients with mitochondrial encephalopathy (ME) and 17 patients with clinically suspected mitochondrial encephalopathy but ultimately diagnosed with non-mitochondrial disease were selected as control group. All patients underwent routine MRI and 1H-MRS examination. The Lac peak were compared between the two groups of patients respectively.Results: Cerebrospinal fluid 1H-MRS showed that 10 cases (10/13) of the cerebrospinal fluid area showed Lac peaks, 3 cases (3/17) of the control group showed Lac peaks in the cerebrospinal fluid area. 1H-MRS showed 5 cases (5/12) Lac peaks were observed in the lesion area of ME. Elevated Lac peaks were observed in the lesion area of the control group in 6 cases (6/16). The sensitivity, correct index, positive likelihood ratio, negative likelihood ratio, and coincidence rate of lac peak in the diagnosis of mitochondrial encephalopathy in the 1H-MRS in cerebrospinal fluid region were better than those in lesion area. Analysis of 1H-MRS diagnosis of mitochondrial encephalopathy combined with cerebrospinal fluid area and lesion area showed that compared with 1H-MRS results of cerebrospinal fluid alone, the sensitivity of the tandem test was reduced, and the specificity was increased. The correct index and coincidence rate of serial and parallel tests were lower than those in the cerebrospinal fluid region.Conclusions: The appearance of Lac peak in cerebrospinal fluid 1H-MRS is superior to that in brain lesion area, which contributes to the lactate level detection in cerebrospinal fluid.
[Keywords] Mitochondrial diseases；Brain diseases；Magnetic resonance spectroscopy

ZHOU Zhi-ling Department of Radiology, Xiangya Hospital Central South University, Changsha 410005, China

LU Jie-yan Department of Radiology, Xiangya Hospital Central South University, Changsha 410005, China

XING Wu Department of Radiology, Xiangya Hospital Central South University, Changsha 410005, China

HU Ping Department of Radiology, Xiangya Hospital Central South University, Changsha 410005, China

LIAO Wei-hua* Department of Radiology, Xiangya Hospital Central South University, Changsha 410005, China

*Correspondence to: Liao WH, E-mail: ouwenliao@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article was funded by the National Natural Science Foundation of China No. 81671676
Received  2018-03-08
Accepted  2018-03-24
DOI: 10.12015/issn.1674-8034.2018.09.001
DOI:10.12015/issn.1674-8034.2018.09.001.

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