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• Clinical Article •
ReHo and ALFF studies in the brain of patients with obstructive sleep apnea hypopnea syndrome
QIN Zong-yuan  BAO Hai-hua  KANG Dong-jie  FENG Xiang  HE Ying 

DOI:10.12015/issn.1674-8034.2018.09.002.


[Abstract] Objective: To investigate the change of brain function in patients with obstructive sleep apnea hypopnea syndrome using regional homogeneity (ReHo) and amplitude of low frequency fluctuation (ALFF).Materials and Methods: Thirty-one patients of OSAHS were recruited from the Affiliated Hospita of Qinghai University and 32 healthy volunteers were recruited. Polysomnography (PSG) and resting state functional magnetic resonance imaging (rs-fMRI) were performed on OSAHS patients and healthy controls.The blood oxygen level dependent (BOLD) signals of OSAHS patients and normal controls were obtained and compared using ReHo and ALFF methods.Results: Compared with the normal group, the OSAHS group has significant differences between ReHo and ALFF. The brain areas with increased ReHo value (P <0.05) are: right medial and paracentral cingulate gyrus, right dorsolateral upper frontal gyrus, left dorsolateral upper frontal gyrus, right middle frontal gyrus, right medial upper frontal gyrus, left medial upper frontal gyrus, right hippocampus. The brain areas with decreased ReHo value (P<0.05) are: right lingual gyrus, left middle temporal gyrus, left postcentral gyrus, right inferior temporal gyrus, left precuneus, right middle temporal gyrus, right precuneus, right superior occipital gyrus. The brain areas with increased ALFF value (P<0.05) are: right dorsolateral upper frontal gyrus, right hippocampus, right insula, right parahippocampal, left hippocampus, right medial and paracentral cingulate gyrus, right middle frontal gyrus. The brain areas with decreased ALFF value (P<0.05) are: right middle occipital gyrus, right inferior occipital gyrus, left middle occipital gyrus, right lingual, left lingual, left inferior occipital gyrus, left middle temporal gyrus, right superior occipital gyrus.Conclusions: The changes in ReHo and ALFF values in multiple brain regions indicate that OSAHS has a certain degree of influence on the brain function of the multiple brain regions of the patient.
[Keywords] Sleep apnea syndromes；Brain injuries；Magnetic resonance imaging

QIN Zong-yuan Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi'ning 810001, China

BAO Hai-hua* Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi'ning 810001, China

KANG Dong-jie Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi'ning 810001, China

FENG Xiang Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi'ning 810001, China

HE Ying Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi'ning 810001, China

*Correspondence to: Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Science and Technology Program Project of Qinghai Provincial Science and Technology Department No.2017-SF-158
Received  2018-04-16
Accepted  2018-07-20
DOI: 10.12015/issn.1674-8034.2018.09.002
DOI:10.12015/issn.1674-8034.2018.09.002.

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