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• Clinical Article •
Study of DCE-MRI and IVIM-DWI on degenerative intervertebral disc neovascularization in patients with low back pain
LI Rui-mei  WANG Dan  WEI Xiao-er  YAO Ting-ting  YU Wei-bin  DIAO Yun-yan  LI Yue-hua 

DOI:10.12015/issn.1674-8034.2018.09.005.


[Abstract] Objective: To evaluate the value of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and incoherent motion diffusion-weighted imaging (IVIM-DWI) in the assessment of the neovascularization of the degenerative intervertebral disc in patients with lower back pain.Materials and Methods: Fifty-one patients with lumbar disc herniation treated by lumbar posterior approach were selected as the experimental group. Eight patients with lumbar fractures were selected as the control group. All subjects underwent IVIM and DCE-MRI examinations before operation, DCE parameters Ktrans, Kep, Ve and IVIM parameters D*, D and f were measured respectively. After operation, immunohistochemistry of intervertebral disc were analyzed. The microvessel density (MVD) was calculated by CD34 labeled vascular endothelial cells. The correlation between the parameters of two imaging modalities and microvessel density was analyzed by Pearson correlation. One-way analysis of variance was used to compare differences in IVIM-DWI and DCE-MRI parameters among patients with different degenerative degrees.Results: The Ktrans value increased with the grade of degeneration (P<0.05). The D value decreased with the grade of degeneration (P<0.05). Ktrans and f values were well correlated with MVD (r=0.794, 0.589, P<0.05).Conclusions: DCE-MRI and IVIM-DWI can observe the vascularization of intervertebral disc degeneration non-invasively and repeatedly. They can also assess the degree of intervertebral disc degeneration.
[Keywords] Microvessels；Intervertebral disc；Low Back pain；Magnetic resonance imaging

LI Rui-mei Department of Radiology, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

WANG Dan Department of Radiology, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

WEI Xiao-er Department of Radiology, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

YAO Ting-ting Department of Radiology, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

YU Wei-bin Department of Radiology, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

DIAO Yun-yan Department of Radiology, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

LI Yue-hua* Department of Radiology, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

*Correspondence to: Li YH, E-mail: liyuehua312@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by National Natural Science Foundation of China No. 81471656 Shanghai Key Discipline of Medical Imaging No. 2017ZZ02005 Supported by Shanghai Municipal Natural Science Foundation No. 14ZR1432100 Clinical Science and Technology Innovation Project of Shanghai Shen Kang Hospital Development Center No. SHDC22015038
Received  2018-05-19
Accepted  2018-07-20
DOI: 10.12015/issn.1674-8034.2018.09.005
DOI:10.12015/issn.1674-8034.2018.09.005.

[1]
Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2197-2223.
[2]
Brooks PM. The burden of musculoskeletal disease-a global perspective. Clin Rheumatol, 2006, 25(6): 778-781.
[3]
Luoma K, Riihimäki H, Luukkonen R, et al. Low back pain in relation to lumbar disc degeneration. Spine, 2000, 25(4): 487-492.
[4]
Khan AN, Jacobsen HE, Khan J, et al. Inflammatory biomarkers of low back pain and disc degeneration: a review. Ann N Y Acad Sci. 2017, 1410(1): 68-84.
[5]
Navone SE, Marfia G, Giannoni A, et al. Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration. Histol Histopathol, 2017, 32(6): 523-542.
[6]
王非，瞿东滨，金大地．生长因子与椎间盘再生．中国修复重建外科杂志, 2003, 17(1): 73-75.
[7]
Meyer HJ, Wienke A, Surov A. Correlation between Ktrans and microvessel density in different tumors: a Meta-analysis. Anticancer Res, 2018, 38(5): 2945-2950.
[8]
Shi C, Liu D, Xiao Z, et al. Monitoring tumor response to anti-vascular therapy using non-contrast intravoxel incoherent motion diffusion-weighted MRI. Cancer Res, 2017, 77(13): 3491-3501.
[9]
Carragee EJ, Don AS, Hurwitz EL, et al. 2009 ISSLS prize winner: does discography cause accelerated progression of degeneration changes in the lumbar disc: a ten-year matched cohort study. Spine, 2009, 34(21): 2338-2345.
[10]
Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol, 1995, 147(1): 9-19.
[11]
Tong SK, Bisdas S, Koh DM, et al. Fundamentals of tracer kinetics for dynamic contrast-enhanced MRI. J Magn Reson Imaging, 2011, 34(6): 1262-1276.
[12]
Antoniou J, Demers CN, Beaudoin G, et al. Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity. Magn Reson Imaging, 2004, 22(7): 963-972.
[13]
胡浩然，李跃华，赵必增．动态对比增强磁共振成像评价腰椎间盘血供的价值．中国矫形外科杂志, 2016, 24(15): 1415-1419.

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