Share：
Share this content in WeChat
X
[Chinese][PDF]668102
• Review •
Clinical research of voxel-based morphometry (VBM) in ophthalmology
LIU Yu-xin  YE Lei  SHAO Yi 

Co-first Author: YE Lei DOI:10.12015/issn.1674-8034.2018.09.010.


[Abstract] With the rapid development of medical imaging technology and increasing requirement of clinical ophthalmic diagnosis, the magnetic resonance imaging (MRI) technology has been widely used in the diagnosis, treatment and the prognostic evaluation of ophthalmic diseases. The voxel-based morphometry (VBM) analyzed the changes in the cerebral gray and white matter density or volume of each voxel in MRI by quantitative calculation, reflecting the difference of the corresponding anatomical structure. In addition, VBM, as a new magnetic resonance imaging technology, has been widely used in the research of clinical ophthalmic diseases in recent years, which provides a powerful tool for elucidating the pathological mechanism and monitoring the course of disease. This paper will briefly review the clinical application of VBM in ophthalmological diseases.
[Keywords] Eye diseases；Gray matter；White matter；Anthropometry；Magnetic resonance imaging

LIU Yu-xin Department of Ophthalmology, The First Affiliated Hospitalof Nanchang University, Nanchang 330006, China

YE Lei Department of Ophthalmology, The First Affiliated Hospitalof Nanchang University, Nanchang 330006, China

SHAO Yi* Department of Ophthalmology, The First Affiliated Hospitalof Nanchang University, Nanchang 330006, China

*Corresponding to: Shao Y, E-mail: freebee99@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Funding from the National Natural Science Foundation No. 81160118, 81460092, 81400372, 81660158 Long Voyage Project in Jiangxi No. 2014022 Major Projects of Jiangxi Natural Science Foundation No. 2016ACB21017 Jiangxi Natural Science Foundation No. 20151BAB215016 Key Research and Development Projects in Jiangxi No. 20151BBG70223
Received  2018-05-03
Accepted  2018-07-21
DOI: 10.12015/issn.1674-8034.2018.09.010
Co-first Author: YE Lei DOI:10.12015/issn.1674-8034.2018.09.010.

[1]
张敬，张成周，张云亭.基于体素的形态学测量技术临床应用进展.国际医学放射学杂志, 2010, 33(4):314-317.
[2]
Kim JH, Kim JB, Seo WK, et al. Volumetric and shape analysis of thalamus in idiopathic generalized epilepsy. J Neurol, 2013, 260(7): 1846-1854.
[3]
Ferreira LK, Diniz BS, Forlenza OV, et al. Neurostructural predictors of Alzheimer's disease: a meta-analysis of VBM studies. Neurobiol Aging, 2011, 32(10): 1733-1741.
[4]
Nenadic I, Dietzek M, Lorenz C, et al. Brain structure in people at ultra-high risk of psychosis, patients with first-episode schizophrenia, and healthy controls: a VBM study. Schizophrenia Research, 2015, 161(2-3): 169-176.
[5]
Zeng Q, Guan X, Jcfly L, et al. Longitudinal alterations of local spontaneous brain activity in Parkinson's disease. Neurosci Bull, 2017, 33(5): 1-9.
[6]
Barrett BT, Bradley A, Candy TR. The relationship between anisometropia and amblyopia. Prog Retin Eye Res, 2013, 36(2): 120-158.
[7]
Bennan JI, Glass HC, Miller SP, et a1. Quantitative fiber tracking analysis of the optic radiation correlated with visual performance in premature newborns. AJNR Am J Neuroradiol, 2009, 30(1): 120-124.
[8]
Mendola JD, Conner IP, Roy A, et al. Voxel-based analysis of MRI detects abnormal visual cortex in children and adults with amblyopia. Hum Brain Mapp, 2005, 25(2): 222-236.
[9]
谢晟，叶锦棠，肖江喜，等．弱视儿童和正常儿童的灰质VBM比较研究．中国斜视与小儿眼科杂志, 2007, 15(1): 1-3.
[10]
Barnes GR, Li XF, Thompson B, et al. Decreased gray matter concentration in the lateral geniculate nuclei in human amblyopes. Invest Ophthalmol Vis Sci, 2010, 51(3):1432-1438.
[11]
姜钦影，李倩，郭明霞，等．屈光参差与屈光不正性弱视儿童脑白质形态学的MRI研究．中国实用眼科杂志, 2012, 30(12): 1408-1412.
[12]
Koc F, Erten Y, Yurdakul NS. Does restoration of binocular vision make any difference in the quality of life in adult strabismus. Br J Ophthalmol, 2013, 97(11): 1425-1430.
[13]
郁佳佳，刘虎．儿童斜视的流行病学研究．中国眼耳鼻喉科杂志, 2013, 13(5): 327-330.
[14]
Chen VJ, Tarczyhornoch K. Functional magnetic resonance imaging of binocular interactions in visual cortex in strabismus. J Pediatr Ophthalmol Strabismus, 2011, 48(6): 366-374.
[15]
Chan ST, Tang KW, Lam KC, et al. Neuroanatomy of adult strabismus: a voxel-based morphometric analysis of magnetic resonance structural scans. Neuroimage, 2004, 22(2): 986-994.
[16]
Ouyang J, Lu Y, Xin H, et al. The atrophy of white and gray matter volume in patients with comitant strabismus: evidence from a voxel-based morphometry study. Mol Med Rep, 2017, 16(3): 3276-3282.
[17]
Yan X, Lin X, Wang Q, et al. Dorsal visual pathway changes in patients with comitant extropia. Plos One, 2010, 5(6): e10931.
[18]
黄歆,卲毅，裴重刚．功能性磁共振成像技术在青光眼中研究进展.中国实用眼科杂志, 2015, 33(4): 329-331.
[19]
Xu ZF, Sun JS, Zhang XH, et al. Microstructural visual pathway abnormalities in patients with primary glaucoma: 3 T diffusion kurtosis imaging study. Clin Radiol, 2018, 73(6): 591.
[20]
Li C, Cai P, Shi L, et al. Voxel-based morphometry of the visual-related cortex in primary open angle glaucoma. Current Eye Research, 2012, 37(9): 794-802.
[21]
陈志祺，高晶，陈威，等．单眼视功能损害的原发性开角型青光眼患者的外侧膝状体损伤．眼科新进展, 2011, 31(8): 758-761.
[22]
Dai H, Yin D, HU C, et al. Whole-brain voxel-based analysis of diffusion tensor MRI parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage. Neuroradiology, 2013, 55(2): 233-243.
[23]
Quigley HA, Bromen AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol, 2006, 90(3): 262-267.
[24]
Hoorbakht H, Bagherkashi F. Optic neuritis, its differential diagnosis and management. Open Ophthalmol J, 2012; 6(1): 65-72.
[25]
田媛，马林．视神经炎的MRI表现及研究进展．中国医学影像学杂志, 2017, 25(10): 785-788.
[26]
孙峥，黄靖，刘亚欧，等.首次发作的视神经炎患者初级视觉皮层功能连接的异常改变．医学影像学杂志, 2016, 26(3): 380-384.
[27]
Oh J, Levy M. Neuromyelitis optica: an antibody-mediated disorder of the central nervous system. Neurol Res Internat, 2012, 2012(2420): 460825.
[28]
Huang X, Zhang Q, Hu PH, et al. White and gray matter volume changes and correlation with visual evoked potential in patients with optic neuritis: a voxel-based morphometry study. Med Sci Monit, 2016, 22: 1115-1123.
[29]
Rocca MA, Agosta F, Mezzapesa DM, et al. Magnetization transfer and diffusion tensor MRI show gray matter damage in neuromyelitis optica. Neurology, 2004, 62(3): 476-478.
[30]
肖慧，马林，陈自谦，等．基于体素的形态测量学技术在视神经脊髓炎脑改变中的初步应用．中华放射学杂志, 2011, 45(4): 336-340.
[31]
段云云，刘亚欧，梁佩鹏，等．应用基于体素的形态测量学方法分析视神经脊髓炎患者的脑体积变化．中华放射学杂志, 2012, 46(11): 983-987.
[32]
Gallo A, Esposito F, Sacco R, et al. Visual resting-state network in relapsing-remitting MS with and without previous optic neuritis. Neurology, 2012, 79(14): 1458-1465.
[33]
Ptito M, Schneider FC, Paulson OB, et al. Alterations of the visual pathways in congenital blindness. Exp Brain Res, 2008, 187(1): 41-49.
[34]
Antony BJ, Chen M, Carass A, et al. Voxel based morphometry in optical coherence tomography: validation & core findings. Proc Spie Int Soc Opt Eng, 2016, 9788: 97880P.
[35]
Borgwardt SJ, Egger H, Kuster P, et al. Effect of immunmodulatory medication on regional gray matter loss in relapsing-remitting multiple sclerosis: a longitudinal VBM study. Neuroimage, 2009, 47(1): S73-S73.
[36]
方玉果. 2型糖尿病伴视网膜病变患者脑rs-fMRI及VBM的研究.大连：大连医科大学, 2017: 18-52.

PREV A case of well-differentiated chondrosarcoma in the sellar region
NEXT The progress of liver fibrosis quantitative evaluation by MRI
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn